Astaxanthin Alleviates Intestinal Ferroptosis through Gut Commensal <i>Lepagella muris</i>-Mediated Retinoic Acid Production and SLC7A11 Activation. [PDF]
Liu S +9 more
europepmc +1 more source
Single-Cell RNA Sequencing Combined with MEBOCOST Reveals Alveolar Macrophage-Mediated Immunometabolic Communication Mechanisms in Sepsis-Induced Acute Lung Injury. [PDF]
Zhao L +5 more
europepmc +1 more source
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen +8 more
wiley +1 more source
Histone Post-Translational Modifications Regulating Ferroptosis: The Molecular Mechanisms and Disease Associations. [PDF]
Tang X +5 more
europepmc +1 more source
ABSTRACT Environmental contaminants like bisphenol A (BPA) and nonylphenol (NP) are recognized neurotoxicants; however, the molecular mechanisms underlying their impact on sensory ganglia, specifically the trigeminal ganglion (TG), remain critically underexplored.
Betül Yazğan +3 more
wiley +1 more source
Maturation‐Dependent Constraints in the Ability of Human Monocytes to Initiate Trained Immunity
In premature infants, innate immune memory may serve as an important compensatory mechanism for the underdeveloped adaptive immune system. However, monocytes derived from prematurely born individuals display abnormal metabolic and insufficient transcriptomic responses to β‐glucan‐induced training.
Michael Eigenschink +10 more
wiley +1 more source
The immunosuppressive in OM Staphylococcus aureus employs multiple physical barriers to evade host immunity during skeletal infection, including biofilm formation on implant surfaces and necrotic bone tissues, invasion into the osteocyte lacuno‐canalicular network (OLCN), intracellular persistence within osteoblasts, osteoclasts, and osteocytes, and ...
Qingqiang Lei +7 more
wiley +1 more source
Loperamide enhances the radiosensitivity of cervical cancer cells via ferroptosis induction. [PDF]
Guo H +5 more
europepmc +1 more source
Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions
Skeletal muscle aging is driven by coordinated local breakdown across myofibers, stem and stromal cells, immune and vascular compartments, and neuromuscular control. These mechanisms promote mitochondrial dysfunction, inflammation, senescence, impaired regeneration, fibrosis, myosteatosis, denervation, and functional decline.
Ting Liu, Yaomin Hu
wiley +1 more source
Desferrioxamine attenuating high glucose-induced ferroptosis and inflammatory responses in Müller glial cells <i>via</i> Nrf2/TXNRD1 pathway. [PDF]
Luo M, Zhang Y, Li N, Zhan WF.
europepmc +1 more source

