Results 161 to 170 of about 21,100 (250)

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, Volume 13, Issue 56, 9 October 2026.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

RNA m6A modification-regulated ferroptosis in cancer: mechanism and therapeutic potential. [PDF]

Front Cell Dev Biol
Shi Q, Li Y, Guan C.
europepmc   +1 more source

The Role of Ferroptosis Induced by Iron Overload in Osteoblast and Osteoclast Function

Cell Biology International, Volume 50, Issue 10, October 2026.
ABSTRACT Iron overload disrupts bone homeostasis by suppressing osteoblast survival and mineralization, while promoting osteoclastogenesis. As a programmed cell death driven by iron‐dependent lipid peroxidation and glutathione peroxidase 4 (GPX4) downregulation. This study investigated the role of ferroptosis in bone cells under iron overload. Exposure
Supagarn Sooksawanwit, Kornkamon Lertsuwan, Natnicha Tannop, Ploypapus Lapatkeattisukul, Thanayuth Jenpichitkulchai, Nittiyaporn Sotapong, Jarinthorn Teerapornpuntakit, Tueanjai Khunluck, Siriwan Punvilai, Narattaphol Charoenphandhu   +9 more
wiley   +1 more source

αO-Conotoxin GeXIVA[1,2] Attenuates Paclitaxel-Induced Neurotoxicity by Suppressing Ferroptosis via the Nrf2/SLC7A11/GSH/GPX4 Pathway. [PDF]

Mar Drugs
Liu D, Yu J, Xu W, Shen Y, Feng X, Li X, Luo S, Bao J, Ding RB.   +8 more
europepmc   +1 more source

DKK1 Promotes Cisplatin Resistance in Oral Squamous Cell Carcinoma via SLC3A2‐Dependent Ferroptosis Suppression

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Oral squamous cell carcinoma (OSCC) is a prevalent malignancy associated with poor outcomes, largely attributable to cisplatin resistance—the standard chemotherapeutic agent. Aims While ferroptosis has been proposed as a promising therapeutic target, how it is regulated in OSCC remains largely unclear.
Zhuoxuan Liu, Xiaolan Chen, Yucong Lin, Lijun Zhu   +3 more
wiley   +1 more source

Disulfidptosis: molecular mechanisms and therapeutic targets. [PDF]

Signal Transduct Target Ther
Wang C, Zhou J, Jin B, Li G, Zhang L, Tian X, Fan Z.   +6 more
europepmc   +1 more source

Insights Into the Role of Platelet Factor 4 in Neurodegenerative Diseases

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
This review summarizes potential functions of platelet factor 4 (PF4) in neurodegenerative diseases (NDs) and discusses its promise as both a biomarker and a therapeutic target. Further elucidation of PF4 signaling pathways may provide new insights into disease mechanisms and uncover novel opportunities for targeted interventions in NDs.
Qi Tian, Yanji Tong, Fang Yu, Xiaoming Hu   +3 more
wiley   +1 more source

RAF1 Promotes Gstt1‐Mediated Ferroptosis by Promoting KDM1A Recruitment to Facilitate Pilocarpine‐Induced Acute Seizure‐Associated Neuronal Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
In the hippocampus of mice with pilocarpine‐induced acute seizures and in glutamate‐treated neuronal cell lines, the mRNA and protein levels of RAF1 were significantly increased. RAF1 interacts with the KDM1A and recruits it to the promoter of Gstt1, thereby inhibiting the transcription of Gstt1.
Tiantian Lu, Yonghong Feng, Xiuling Chen, Liyan Shen, Min Liu, Yanping Jia   +5 more
wiley   +1 more source

Echinacoside Alleviates Cisplatin-Induced Acute Kidney Injury by Regulating Bap1 to Inhibit Ferroptosis. [PDF]

Biomedicines
Chen L, Zhang M, Chi M, Ye Z, Li B, Yang S, Zhang M, Dong W, Li H, Zhou X.   +9 more
europepmc   +1 more source

Modulation of Endoplasmic Reticulum Stress via CEBPB: A Potential Molecular Link to Therapeutic Action in Substance Use Disorders

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
We identified endoplasmic reticulum (ER) stress modulation as a convergent transcription signature across fentanyl and multiple substance use disorder (SUD)‐relevant treatments. Key ER stress genes, including TRIB3, XBP1, and DDIT3, were downregulated, while CEBPB emerged as a shared upstream regulator linked to ER stress–related proteins.
Cheng Zhang, Hu Li, Ming‐Fen Ho
wiley   +1 more source