Results 141 to 150 of about 20,364 (275)

Kaempferol Attenuates Myocardial Ischemia–Reperfusion Injury by Suppressing Ferroptosis via the KEAP1–Nrf2–GPX4 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Myocardial ischemia/reperfusion (I/R) injury is characterized by cardiomyocyte death, excessive oxidative stress, inflammation, and ferroptosis, which collectively limit the efficacy of reperfusion therapy. In this study, we investigated whether kaempferol (KAE), a natural flavonol with antioxidative and antiinflammatory properties, could ...
Yan‐Bo Zhao, Ling‐Ling Sun, Xiao‐Hua Shen, Min Wang, Mei‐Hui Wang, Lu‐Lu Liu, Kai Zhang   +6 more
wiley   +1 more source

N6-methyladenosine RNA modification regulates the transcription of SLC7A11 through KDM6B and GATA3 to modulate ferroptosis

Background Recent studies indicate that N6-methyladenosine (m6A) RNA modification may regulate ferroptosis in cancer cells, while its molecular mechanisms require further investigation.
Wanglin Li, Jianxin Peng, Lijun Tao, Haoran Wang, Gholamreza Asadikaram, Jie Cao, Junming He, Jianing Li, Jiawang Zhou, Yonghuang Tan, Zhuojia Chen, Cheng Yi, Yunqing Lu, Haisheng Zhang, Hongsheng Wang, Jiexin Li   +15 more
core   +1 more source

SLC7A11 wt Allele [PDF]

, 2020
openaire   +1 more source

Ferroptosis and Its Emerging Role in Gestational Diabetes Mellitus

Medicine Advances, EarlyView.
Ferroptosis contributes to the development of gestational diabetes mellitus (GDM) through iron overload, lipid peroxidation, and antioxidant system disruption. These changes impair adipocyte and β‐cell function, promoting insulin resistance and hyperglycemia.
Jinfeng Xu, Yuan Tian, Hongbin Zhu, Bing Peng, Chunheng Mo   +4 more
wiley   +1 more source

HSPA9 contributes to tumor progression and ferroptosis resistance by enhancing USP14-driven SLC7A11 deubiquitination in multiple myeloma

Cell Reports
Summary: Ferroptosis, a regulated cell death triggered by overload-dependent lipid peroxidation, is implicated in multiple human cancers. The mechanisms underlying ferroptosis in multiple myeloma (MM) remain enigmatic.
Na Shen, Yuan Xia, Xuxing Shen, Wei Hua, Min Shi, Lijuan Chen   +5 more
doaj   +1 more source

The Role of SLC7A11 in Tumor Progression and the Regulation Mechanisms Involved in Ferroptosis

Cancer Management and Research
SLC7A11 (xCT) is a key subunit of the cysteine/glutamate transporter (system xc -), which is crucial for maintaining cellular redox homeostasis (especially glutathione synthesis) and regulating Ferroptosis. It is highly expressed in various malignant tumors and is a key factor leading to treatment resistance, making it an important anti-cancer target ...
Zhang,Xizheng, Zhang,Yao, Wei,Jiayu, Li,Xuyan, Jiang,Anqi, Shen,Ying, Hou,Yongzhong, Liu,Qian   +7 more
openaire   +3 more sources

RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment

Precision Medical Sciences, EarlyView.
This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run, Shiwei Jiang, Kun Xu, Yu Fan, Yanwen Chen, Ziao Liu, Zengli Miao, Wei Tian   +7 more
wiley   +1 more source

High Co-Expression of GPAT4 and SLC7A11 as a Predictor of Platinum Resistance and Poor Prognosis in Patients with Epithelial Ovarian Cancer

Biomedicines
Background/Objectives: This study aimed to determine whether the expression levels of GPAT4 and SLC7A11 are associated with survival outcomes and platinum resistance in epithelial ovarian cancer (EOC) patients. Methods: We analyzed the medical records of
Ping Yu, Chunliang Shang, Zhongyu Liu, Yuan Li, Tianhui He, Yuan Xue, Jian Lin, Yuan Li, Yu Wu, Tong Liu, Hongyan Guo   +10 more
doaj   +1 more source

EFNA4-enhanced deubiquitination of SLC7A11 inhibits ferroptosis in hepatocellular carcinoma

Apoptosis
EFNA4, a member of the Ephrin-A ligand family, may influence hepatocellular carcinoma cells through two distinct mechanisms: one reliant on specific Eph receptor binding and the other independent of receptor involvement. However, EFNA4's influence on HCC via non-Eph receptor pathways remains unclear.
Zhong, Xingyi, Zhu, Zhiqin, Du, Yangfeng, Long, Lingzhi, Xie, Ziping, Zhang, Yangfeng, Yao, Huijun, Lin, Junhao, Chen, Fengsheng   +8 more
openaire   +2 more sources

The role of SLC7A11 in diabetic wound healing: novel insights and new therapeutic strategies [PDF]

Diabetic wounds are a severe complication of diabetes, characterized by persistent, non-healing ulcers due to disrupted wound-healing mechanisms in a hyperglycemic environment.
Wei Zhang, Yiming Ni, Jiawei Feng, Gen Li, Yemin Cao, Yuqing Wang, Cheng Zhao, Mingmei Zhou   +7 more
core   +1 more source