Results 141 to 150 of about 19,150 (245)

Hederagenin Promotes Sorafenib Sensitivity in Hepatocellular Carcinoma Through Suppressing SLC7A11 Expression and Inducing Ferroptosis. [PDF]

Food Sci Nutr
Jiang HM, Zhou YW, Zhang JY, Pan FZ, Zhang JF, Zhang YG.   +5 more
europepmc   +1 more source

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source

LRP1 activated by AT2 cell-secreted MDK inhibits fibrotic ferroptosis in idiopathic pulmonary fibrosis. [PDF]

iScience
Hua W, Wang Z, Dai Z, Zhang Z, Li X, Wu B, Huang M, Chen J.   +7 more
europepmc   +1 more source

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

Cephaeline promotes ferroptosis in breast cancer via p53/SLC7A11/GPX4 axis. [PDF]

Daru
Li X, Yu J, Lin B, Gong Y.
europepmc   +1 more source

P53 Competitively Binds P300 to Suppress HIF‐1α/TFRC‐Mediated Ferroptosis and Promote Doxorubicin Resistance in Breast Cancer

The FASEB Journal, Volume 40, Issue 16, 31 August 2026.
Upregulated P53 competitively binds P300, reducing its availability to HIF‐1α and thereby decreasing HIF‐1α/P300 co‐occupancy and transcriptional activation at the TFRC promoter. The resulting reduction in TFRC‐dependent iron uptake weakens Fenton reactions, lipid peroxidation, and ferroptosis, ultimately promoting doxorubicin resistance in breast ...
Xiaojie Yu, Longdi Yao, Shuchun Zhang, Xiao Huang, An Xu, Deyuan Fu   +5 more
wiley   +1 more source

PCK2 Inhibition Reverses Cisplatin Resistance of Non‐Small Cell Lung Cancer by Triggering Ferroptosis

The FASEB Journal, Volume 40, Issue 16, 31 August 2026.
Metabolic enzyme PCK2 is aberrantly upregulated in cisplatin‐resistant NSCLC cells, which inhibits ferroptosis and ultimately facilitates tumor chemoresistance. The small‐molecule inhibitor RGB‐286638 directly binds to the key R454 functional site of PCK2 protein, efficiently inhibits PCK2 expression, and rescues PCK2‐mediated ferroptosis suppression ...
Jing Liu, Ziyan Wang, Chen Gu, Yili Chen, Yang Yang, Jianjie Zhu, Yihua Zhang, Yuna Shao, Xiaodong Pang, Yujie Ge, Huiwen Qian, Jian‐an Huang, Zeyi Liu, Yuanyuan Zeng, Cheng Ji   +14 more
wiley   +1 more source

A context-dependent METTL1-m7G-SLC7A11 axis links metabolic stress to epithelial fate in ulcerative colitis. [PDF]

Int J Biol Sci
Yang L, Sun Q, Jiang Z, Yao B, Yang C, Liu G, Yuan L.   +6 more
europepmc   +1 more source

Globo‐H diagnostic stratification and identification of DUSP14 as a candidate target in colorectal cancer

International Journal of Cancer, Volume 159, Issue 4, Page 936-950, 15 August 2026.
What's new? Colorectal cancer (CRC) is increasingly complicated by drug‐resistant tumors that limit the effectiveness of anticancer therapies. Because resistance mechanisms vary among patients and can evolve over time, personalized treatment strategies are needed.
Keren Zohar, Marco Strecker, Thomas Wartmann, Wenjie Shi, Frederike Stelter, Maximilian Doelling, Mihailo Andric, Or Kakhlon, Christian Täger, Denny Schanze, Michael Linnebacher, Michael Naumann, Daniel E. Stange, Dörthe Jechorek, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Disulfidptosis: The metabolic Achilles' heel of SLC7A11-high tumors and why oncology has missed it. [PDF]

Ann Med Surg (Lond)
Khawar MMH, Naeem I, Safi SU, Khawar M.
europepmc   +1 more source