Targeting Ferroptosis to Overcome Radioresistance and Enhance Immunotherapy in Colorectal Cancer. [PDF]
CellsSoltani Tehrani S +4 more
europepmc +1 more source
ATF4/SCO2 Inhibits Ferroptosis in Lung Cancer Through Activating the MAPK Signaling Pathway
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.ATF4 activates the transcription of SCO2 to increase SCO2 expression that further stimulates p38/ERK1 signals in MAPK pathway, ultimately promoting proliferation and migration while inhibiting apoptosis and ferroptosis of lung cancer cells. ABSTRACT Ferroptosis is a specific cell death form resulting from the iron‐dependent lipid peroxidation ...
Liang Yu +6 more
wiley +1 more source
Post-Translational Modification Networks in Ferroptosis: Orchestrating Defense, Drug Resistance, and Therapeutic Opportunities in Hepatocellular Carcinoma. [PDF]
J Hepatocell CarcinomaChen J, Li L, Fang S, Zhou H.
europepmc +1 more source
The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 8, August 2026.ABSTRACT The prevalence of postmenopausal osteoporosis (PMOP) has been steadily increasing. Ferroptosis has been recognized as a critical factor influencing the bone‐forming ability of bone marrow mesenchymal stem cells (BMSCs). Valproic acid (VPA), an HDAC inhibitor, has been suggested to play a role in regulating osteoporosis development; however ...
Qing‐Song Gu +8 more
wiley +1 more source
Danshensu Ethyl Ester Induces Ferroptosis Through Targeted Inhibition of SLC7A11 Transport Function in NSCLC. [PDF]
Thorac CancerYan R +10 more
europepmc +1 more source
MedComm, Volume 7, Issue 8, August 2026.Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong +8 more
wiley +1 more source
Pathogenesis of Osteoarthritis: Mechanisms of Action of Disulfidptosis and Targeted Therapeutic Strategies. [PDF]
Drug Des Devel TherLiang Y +5 more
europepmc +1 more source
Amino Acid and Lipid Metabolism in Cancer: Mechanisms and Therapeutic Opportunities
MedComm, Volume 7, Issue 8, August 2026.Amino Acid and lipid metabolism in cancer: (A) Regulation of Amino acid transportation and metabolism in cancer. (B) The core organization of lipid metabolic reprogramming in cancer and their functional consequences. ABSTRACT Metabolic reprogramming is a defining feature of cancer and a major contributor to immune escape.
Zixu Wang +4 more
wiley +1 more source
Exploring and experimental validation of SLC7A11 and ferroptosis related prognostic genes in non-small cell lung cancer using bulk RNA sequencing and single-cell RNA sequencing. [PDF]
Biol DirectDiao X, Pan S, Duan Y, Di L.
europepmc +1 more source
MedComm, Volume 7, Issue 8, August 2026.Under the treatment of ferroptosis inducers, the expression of SEPHS2 is upregulated, driven by ATF4, to increase the biosynthesis of selenoproteins (e.g., GPX4) to promote resistance to ferroptosis. ABSTRACT While it has been reported that antioxidant selenoproteins are crucial for anti‐ferroptosis in tumors, it remains unclear whether and how ...
Shijia Bao +9 more
wiley +1 more source