Results 221 to 230 of about 21,100 (250)
OTUD5 promotes AML progression by stabilizing SLC7A11 to suppress ferroptosis. [PDF]
Cell CycleChen X +7 more
europepmc +1 more source
Blue Light Pollution and Ocular Surface Toxicity: p53-Mediated Ferroptosis in Corneal Epithelium Drives Dry Eye Pathogenesis. [PDF]
Antioxidants (Basel)Zhang L +5 more
europepmc +1 more source
Journal of Diabetes Investigation, Volume 17, Issue 10, Page 1639-1642, October 2026.
wiley +1 more source
The Role of SLC7A11 in Cancer: Friend or Foe?
Cancers, 2022 SLC7A11 controls the uptake of extracellular cystine in exchange for glutamate at a ratio of 1:1, and it is overexpressed in a variety of tumours. Accumulating evidence has shown that the expression of SLC7A11 is fine-tuned at multiple levels, and plays diverse functional and pharmacological roles in tumours, such as cellular redox homeostasis, cell ...
Runbin Sun, Bei Cao
exaly +3 more sources
Slc7a11 Modulated by POU2F1 is Involved in Pigmentation in Rabbit [PDF]
International Journal of Molecular Sciences, 2019 Abstract Solute carrier family 7 member 11 (Slc7a11) codes for a cystine/glutamate xCT transporter and can control production of pheomelanin pigment to change fur and skin colors of animals. Previous studies found that the skin expression levels of Slc7a11 varied significantly with the fur colors of the Rex Rabbit.
Bohao Zhao, Xinsheng Wu, Naisu Yang
exaly +3 more sources
Role of SLC7A11/xCT in Ovarian Cancer
International Journal of Molecular SciencesOvarian cancer is one of the most dangerous gynecologic cancers worldwide and has a high fatality rate due to diagnosis at an advanced stage of the disease as well as a high recurrence rate due to the occurrence of chemotherapy resistance. In fact, chemoresistance weakens the therapeutic effects, worsening the outcome of this pathology.
Giovanni Tossetta +2 more
exaly +4 more sources
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Ferroptosis and Neurodegenerative Diseases: Insights into the Regulatory Roles of SLC7A11
Cellular and Molecular Neurobiology, 2023Programed cell death plays a key role in promoting human development and maintaining homeostasis. Ferroptosis is a recently identified pattern of programmed cell death that is closely associated with the onset and progression of neurodegenerative diseases. Ferroptosis is mainly caused by the intracellular accumulation of iron-dependent lipid peroxides.
Bin Xu, Tianyao Yang
exaly +3 more sources
Die Pharmazie, 2017
Antisense lncRNAs play a key role in the progression of multiple cancers. Thus, it is important to elucidate the function and mechanism of antisense lncRNAs, which may play a role in the treatment of epithelial ovarian cancer (EOC). In the current study, for the first time, we showed that the level of As-SLC7A11 was markedly reduced in EOC cancer ...
Jinjin Yuan, Jinjin Yuan +2 more
openaire +2 more sources
Antisense lncRNAs play a key role in the progression of multiple cancers. Thus, it is important to elucidate the function and mechanism of antisense lncRNAs, which may play a role in the treatment of epithelial ovarian cancer (EOC). In the current study, for the first time, we showed that the level of As-SLC7A11 was markedly reduced in EOC cancer ...
Jinjin Yuan, Jinjin Yuan +2 more
openaire +2 more sources
SLC7A11/xCT Prevents Cardiac Hypertrophy by Inhibiting Ferroptosis
Cardiovascular Drugs and Therapy, 2021Systemic hypertension may induce adverse hypertrophy of the left cardiac ventricle. Pathological cardiac hypertrophy is a common cause of heart failure. We investigated the significance of ferroptosis repressor xCT in hypertrophic cardiomyopathy.xCT expression in angiotensin II (Ang II)-treated mouse hearts and rat cardiomyocytes was determined using ...
Xiyu, Zhang +11 more
openaire +2 more sources