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Role of SLC7A11/xCT in Ovarian Cancer

International Journal of Molecular Sciences
Ovarian cancer is one of the most dangerous gynecologic cancers worldwide and has a high fatality rate due to diagnosis at an advanced stage of the disease as well as a high recurrence rate due to the occurrence of chemotherapy resistance. In fact, chemoresistance weakens the therapeutic effects, worsening the outcome of this pathology.
Giovanni Tossetta, Angelo Sirico, Daniela Marzioni   +2 more
exaly   +4 more sources

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Ferroptosis and Neurodegenerative Diseases: Insights into the Regulatory Roles of SLC7A11

Cellular and Molecular Neurobiology, 2023
Programed cell death plays a key role in promoting human development and maintaining homeostasis. Ferroptosis is a recently identified pattern of programmed cell death that is closely associated with the onset and progression of neurodegenerative diseases. Ferroptosis is mainly caused by the intracellular accumulation of iron-dependent lipid peroxides.
Bin Xu, , Tianyao Yang
exaly   +3 more sources

Antisense lncRNA As-SLC7A11 suppresses epithelial ovarian cancer progression mainly by targeting SLC7A11

Die Pharmazie, 2017
Antisense lncRNAs play a key role in the progression of multiple cancers. Thus, it is important to elucidate the function and mechanism of antisense lncRNAs, which may play a role in the treatment of epithelial ovarian cancer (EOC). In the current study, for the first time, we showed that the level of As-SLC7A11 was markedly reduced in EOC cancer ...
Jinjin Yuan, Jinjin Yuan, Zongwen Liu, Zongwen Liu, Rui Song, Rui Song   +2 more
openaire   +2 more sources

SLC7A11/xCT Prevents Cardiac Hypertrophy by Inhibiting Ferroptosis

Cardiovascular Drugs and Therapy, 2021
Systemic hypertension may induce adverse hypertrophy of the left cardiac ventricle. Pathological cardiac hypertrophy is a common cause of heart failure. We investigated the significance of ferroptosis repressor xCT in hypertrophic cardiomyopathy.xCT expression in angiotensin II (Ang II)-treated mouse hearts and rat cardiomyocytes was determined using ...
Xiyu, Zhang, Cuiting, Zheng, Zhenqiang, Gao, Hongyu, Chen, Kai, Li, Lingling, Wang, Yuanyuan, Zheng, Chunjia, Li, Hongjia, Zhang, Ming, Gong, Hongbing, Zhang, Yan, Meng   +11 more
openaire   +2 more sources

Role of Slc7a11 in Bleomycin-Induced Lung Injury

Lung
Oxidative stress has been implicated in lung injury and repair. We seek to understand how alterations in the plasma redox potential (Eh) of the thiol disulfide couple cysteine (Cys) and cystine (CySS) (Eh Cys/CySS) affect this process. Previously, we reported that Eh Cys/CySS oxidation promotes a pro-fibrotic phenotype in lung fibroblasts and ...
Jeffrey D, Ritzenthaler, Edilson, Torres-Gonzalez, Yvonne, Janssen-Heininger, Walter H, Watson, Jesse, Roman   +4 more
openaire   +2 more sources

AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

Science China Life Sciences
Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed.
Chen, Xiong, Hong, Ling, Yingdan, Huang, Hanzhi, Dong, Bangxiang, Xie, Qian, Hao, Xiang, Zhou   +6 more
openaire   +2 more sources

SLC7A11 as a prognostic biomarker for hepatocellular carcinoma.

Journal of Clinical Oncology
e16004 Background: Disulfidptosis has been discovered as a mechanism of cell death mediating by SLC7A11. Nonetheless, little is known about the relationship between SLC7A11 and hepatocellular carcinoma (HCC). Methods: The clinical and follow-up data of 84 consecutive HCC cases who met the inclusion criteria from 2016 to 2019 were retrospectively ...
Yuxi Wang, Xi Li, Ya Zhou, Xiao Meng, Ying Wang, Xiaomei Liu   +5 more
openaire   +1 more source

Nanomedicine strategies for disulfidptosis activation in SLC7A11-high tumors

Colloids and Surfaces B: Biointerfaces
Disulfidptosis is a recently identified form of regulated cell death (RCD) characterized by aberrant disulfide bond accumulation and cytoskeletal collapse under conditions of redox imbalance. SLC7A11-overexpressing tumors are uniquely susceptible to this pathway due to their elevated cystine uptake and dependence on glucose-driven NADPH production for ...
Zhanzheng Ye, Yinsha Yao, Yitianhe Xu, Jinyao Ye, Qing Yao, Longfa Kou, Ruijie Chen   +6 more
openaire   +2 more sources

SLC7A11 and NLRP1 in non-small cell lung cancer

Clinica Chimica Acta
To critically evaluate SLC7A11 (solute carrier family 7 member 11) and NLRP1 (NOD-like receptor family pyrin domain containing 1) as clinical laboratory biomarkers in NSCLC, with emphasis on preanalytical control, assay selection/validation, and decision-use cases. Non-small cell lung cancer (NSCLC) requires strong and standard biomarkers for diagnosis,
Abida, Khan, Abdullah R, Alzahrani, Talha, Jawaid, Maha M, Al-Bazi, Abeer A, Banjabi, Abdul, Hai, Mohd, Imran, Zia Ur, Rehman   +7 more
openaire   +2 more sources

Galectin-13 reduces membrane localization of SLC7A11 for ferroptosis propagation

Nature Chemical Biology
The mechanism of ferroptosis propagation is still unclear. Here our results indicate that the cells undergoing ferroptosis secrete Galectin-13, which binds to CD44 and inhibits the plasma membrane localization of SLC7A11 in neighboring cells, thereby accelerating neighboring cell death and promoting ferroptosis propagation.
Hai-Liang Zhang, Yi-Qing Guo, Shan Liu, Zhi-Peng Ye, Li-Chao Li, Bing-Xin Hu, Zhi-Ling Li, Yu-Hong Chen, Gong-Kan Feng, Hui-Qi Shen, Rong Deng, Xiao-Feng Zhu   +11 more
openaire   +2 more sources