Results 241 to 250 of about 20,364 (275)

Multifunctional Role of Mitochondrial Fatty Acid Oxidation in Cancer Immunotherapy and Aging

Cancer Science, Volume 117, Issue 6, Page 1554-1565, June 2026.
Recent studies have highlighted the complex interplay between tumor immunity, aging, and inflammation. Mitochondrial FAO is a major hub of this physiological interplay. ABSTRACT Recent studies have demonstrated the intricate relationship between tumor immunity, aging, and inflammation.
Koji Kitaoka, Shuhei Hirose, Yu Wang, Tomonori Yaguchi, Kenji Chamoto   +4 more
wiley   +1 more source

LncRNA SLC7A11-AS1 suppresses the ferroptosis of bladder cancer cells through regulating SLC7A11 by IGF2BP1 via m6A modification

Journal of Radiation Research and Applied Sciences
Ganshen Yu, Zhihai Deng, Jingyao Huang, Kaizhong Zhang, Caiyong Lai   +4 more
openaire   +1 more source

Vaccinia-related kinase 2 inhibition elicits vulnerability of glutathione metabolism in pancreatic cancer. [PDF]

Cell Death Dis
Chen S, Fu X, Zhang T, Zhou R, Liu L, Zeng L, Xu B, Zhu H, Li Z.   +8 more
europepmc   +1 more source

Mechanistic Insights Into Recurrent Implantation Failure: The Lactate–H3K18la–SLC7A11 Axis Explored via Endometrial Organoid and Blastoid–Endometrial Cell Implantation Models

Cell Proliferation, Volume 59, Issue 6, June 2026.
Clinical samples first revealed impaired lactate synthesis in RIF patients. Subsequently, using endometrial organoids and a blastoid‐endometrial cell implantation model, we demonstrated that lactate enhances endometrial receptivity via H3K18la‐mediated SLC7A11 activation.
Lingling Dong, Xiaobin Sun, Shiyu An, Jinfeng Xiang, Lingmin Hu, Dan Yao, Jiaqian Chang, Ruizhe Jia, Yang Yang, Shuxian Wang   +9 more
wiley   +1 more source

Berberine from Tibetan Medicine <i>Dracocephalum tanguticum</i> Maxim Suppresses Colorectal Tumor Growth and Inhibits CD8⁺ T Cells Ferroptosis via the NRF2-SLC7A11-GPX4 Axis. [PDF]

Cancer Manag Res
Wang Y, Zhang Y, Wang Q, Zheng L, Liu Y.
europepmc   +1 more source

Coenzyme A mitigates cystine‐deprivation‐induced ferroptosis by suppressing the iron‐starvation response

The FEBS Journal, Volume 293, Issue 11, Page 3288-3302, June 2026.
Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang   +8 more
wiley   +1 more source

Bufalin Suppresses Pancreatic Ductal Adenocarcinoma Through ER Stress-Ferroptosis Crosstalk Associated with IP₃R-Linked Ca²⁺ Dysregulation and ATF3/SLC7A11 Regulation. [PDF]

Int J Mol Sci
Yang PW, Li X, Si WM, Zhang Y, Kong XY, Xu XY, Zhu XY, Chen Z.   +7 more
europepmc   +1 more source

Diabetes and Delayed Wound Healing: Molecular Mechanisms and Dermatological Interventions

International Wound Journal, Volume 23, Issue 6, June 2026.
ABSTRACT Diabetes mellitus is a global burden that affects wound healing at nearly every stage, transforming what should be a coordinated and self‐limited repair process into a chronic, non‐healing state. In diabetic patients, sustained hyperglycemia drives persistent inflammation, impaired angiogenesis, fibroblast dysfunction and extracellular matrix ...
Sasha Jreije, Marwan Fadel, Carl Karam, Hilda E. Ghadieh, Antoine Ghanem   +4 more
wiley   +1 more source

The oncogenic effect and mechanism of LINC00520/miR-372/SLC7A11 axis in renal clear cell carcinoma. [PDF]

Sci Rep
Chen YB, Tang LY, Luo RT, Lv D, Liu YW.
europepmc   +1 more source

Tumor cell ferroptosis in antitumor immunity and immunotherapy efficacy. [PDF]

J Immunother Cancer
Li S, Gajewski T.
europepmc   +1 more source