Results 181 to 190 of about 217,308 (243)

Piezo1‐Mediated Mechanotransduction: Orchestrating the Dynamic Response of Podocytes and Parietal Epithelial Cells to Mechanical Stress

Acta Physiologica, Volume 242, Issue 3, March 2026.
ABSTRACT Aim The glomerulus is a specialized microvascular unit that filters plasma through the coordinated function of podocytes and parietal epithelial cells (PECs). From this perspective, the glomerulus functions like a living hydrogeological filtration system.
Maria Elena Melica, Giulia Antonelli, Anna Julie Peired, Laura Lasagni   +3 more
wiley   +1 more source

Cut Finite Element 3D Acoustic Shape Optimization of a Compression Driver Taking Viscothermal Losses Into Account

International Journal for Numerical Methods in Engineering, Volume 127, Issue 4, 28 February 2026.
ABSTRACT Wave propagation effects such as resonance and interference effects complicate the design of many acoustic devices, particularly when the dimensions of the device are in the order of the operating wavelength. At the same time, these complications also offer an opportunity for numerical optimization schemes to outperform designs achieved using ...
Martin Berggren, Anders Bernland, André Massing, Daniel Noreland, Eddie Wadbro   +4 more
wiley   +1 more source

WNK1 Kinase Activity Is Required for the Functional Maintenance of Podocyte Structure

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
The acute effects of WNK1 kinase inhibition on podocyte structure and function were determined at the level of: 1) renal function, by measurements of urinary protein and imaging of glomerular synaptopodin, 2) podocyte cell, by measurements and localization of actomyosin proteins and their regulators, and 3) focal adhesions at cell membrane extensions ...
Zhenan Liu, Eunyoung Lee, Shumeng Jiang, Joonho Yoon, Fouzia Ahmed, Mohammad A. Rahman, Philip Bleicher, Hani Y. Suleiman, Leslie A. Bruggeman, R. Tyler Miller, Audrey N. Chang   +10 more
wiley   +1 more source

Slit Diaphragm Molecular Changes in Recurrent FSGS With Antinephrin Autoantibodies. [PDF]

Kidney Int Rep
Shirai Y, Miura K, Horita S, Ito N, Taneda S, Koike J, Honda K, Hattori M.   +7 more
europepmc   +1 more source

The native human glomerulus features a slit diaphragm resembling a densely interwoven fishnet. [PDF]

JCI Insight
Moser D, Birtasu AN, Skaer L, Roth P, Rehm L, Wenzel M, Bein J, Köllermann J, Mantanya MS, Chun FK, Scheffer MP, Frangakis AS.   +11 more
europepmc   +1 more source

Synbindin downregulation participates in slit diaphragm dysfunction

Synbindin downregulation participates in slit diaphragm dysfunction
Introduction: Synbindin, originally identified as a neuronal cytoplasmic molecule, was found in glomeruli. cDNA subtractive hybridization technique showed the mRNA expression of synbindin in glomeruli was down-regulated in puromycin aminonucleoside (PAN) nephropathy, a mimic of minimal-change nephrotic syndrome.
openaire  

Phospholipid scramblase 1: an essential component of the nephrocyte slit diaphragm. [PDF]

Cell Mol Life Sci
Castillo-Mancho V, Atienza-Manuel A, Sarmiento-Jiménez J, Ruiz-Gómez M, Culi J.   +4 more
europepmc   +1 more source

Dynamics at the slit diaphragm--is nephrin actin'? [PDF]

Nephrology Dialysis Transplantation, 2006
openaire   +2 more sources

Podocytes are key—although albumin never reaches the slit diaphragm [PDF]

Nature Reviews Nephrology, 2014
Marcus J, Moeller, George A, Tanner
openaire   +2 more sources

Structural continuity of filtration slit (slit diaphragm) to plasma membrane of podocyte

Structural continuity of filtration slit (slit diaphragm) to plasma membrane of podocyte
Murine monoclonal antibody 5-1-6 was reported to bind to the slit membrane and closely related structures in rat renal glomeruli; it induced heavy, reversible proteinuria and appeared to redistribute onto the plasma membrane of epithelial cells after binding at the original target sites.
openaire