Results 181 to 190 of about 17,762 (221)

Emerging Role of FAT Atypical Cadherin 1 in Kidney Function and Disease. [PDF]

J Am Soc Nephrol
Oteyola AO, Chan B, Quintar AA, Riascos-Bernal DF, Ross MJ, Sibinga NES, Sibinga NES, Chen W.   +7 more
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Synbindin Downregulation Participates in Slit Diaphragm Dysfunction

American Journal of Nephrology, 2021
<b><i>Introduction:</i></b> Synbindin, originally identified as a neuronal cytoplasmic molecule, was found in glomeruli. The cDNA subtractive hybridization technique showed the mRNA expression of synbindin in glomeruli was downregulated in puromycin aminonucleoside (PAN) nephropathy, a mimic of minimal-change nephrotic syndrome.
Veniamin, Ivanov, Yoshiyasu, Fukusumi, Ying, Zhang, Hidenori, Yasuda, Meiko, Kitazawa, Hiroshi, Kawachi   +5 more
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Advances in slit diaphragm signaling

Current Opinion in Nephrology and Hypertension, 2014
The podocyte slit diaphragm is a fundamental component of the glomerular filtration barrier and its function is highly dependent on the maintenance of specialized actin-based projections known as foot processes. In this review, we update the function of key slit diaphragm-associated proteins, and introduce some new players and emerging avenues of ...
Laura A, New, Claire E, Martin, Nina, Jones   +2 more
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Molecular understanding of the slit diaphragm

Pediatric Nephrology, 2012
Glomerular filtration has always attracted the interest of nephrologists and renal researchers alike. Although several key questions on the structure and function of the kidney filter may have been answered within the last 40 years of intense research, there still remain crucial questions to be solved.
Grahammer, Florian, Schell, Christoph, Huber, Tobias B.   +2 more
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Molecular structure-function relationship in the slit diaphragm

Seminars in Nephrology, 2003
The past 5 years have witnessed an exponential increase in our understanding of the structure and function of the glomerular slit diaphragm. The identification of nephrin as the first transmembrane slit diaphragm protein was a watershed event in slit diaphragm biology.
Sumant S, Chugh, Beenu, Kaw, Yashpal S, Kanwar   +2 more
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Clinical impact of research on the podocyte slit diaphragm

Nature Clinical Practice Nephrology, 2006
This Review summarizes recent research on the podocyte slit diaphragm. A growing number of molecules that function at the slit diaphragm have been identified in patients with inherited and sporadic nephrotic syndromes. Genetic deletion of nearly all of these molecules results in proteinuria and effacement of foot processes.
Duncan B, Johnstone, Lawrence B, Holzman
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Slit Diaphragm Junctional Complex and Regulation of the Cytoskeleton

Nephron Experimental Nephrology, 2007
In recent years, identification of proteins found at the slit diaphragm has greatly improved our understanding of the molecular mechanisms responsible for forming and maintaining the glomerular filtration barrier. This review examines the function of proteins identified at the podocyte intercellular junction in coordinating podocyte intercellular ...
Puneet, Garg, Rakesh, Verma, Lawrence B, Holzman   +2 more
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The molecular architecture of the kidney slit diaphragm

2023
AbstractVertebrate life depends on renal function to filter excess fluid and remove low-molecular-weight waste products. An essential component of the kidney filtration barrier is the slit diaphragm (SD), a specialized cell-cell junction between podocytes. Although the constituents of the SD are largely known, its molecular organization remains elusive.
Alexandra N. Birtasu, Konstantin Wieland, Utz H. Ermel, Johanna V. Rahm, Margot P. Scheffer, Benjamin Flottmann, Mike Heilemann, Florian Grahammer, Achilleas S. Frangakis   +8 more
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ER stress and slit diaphragms: is there a connection?

Kidney International, 2023
Galloway-Mowat syndrome is a neurorenal syndrome that has been linked with defective transfer RNA and protein translation caused by variants in the multiprotein complex KEOPS. In the kidney, this syndrome seems to primarily affect the podocytes, but the pathogenesis has remained unclear. In this issue of Kidney International, Krausel et al.
Hermle, Tobias, Simons, Matias
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Rapid screening of glomerular slit diaphragm integrity in larval zebrafish

American Journal of Physiology-Renal Physiology, 2007
Gene array-type experiments have identified large numbers of genes thought to be important for the integrity of the glomerular slit diaphragm. Confirmation of individual proteins has been limited by the expenses and time involved in generating transgenic or knockout mice for each candidate. We present a functional screening assay based on the clearance
Dirk M, Hentschel, Michael, Mengel, Lisa, Boehme, Fabian, Liebsch, Caroline, Albertin, Joseph V, Bonventre, Hermann, Haller, Mario, Schiffer   +7 more
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