Results 201 to 210 of about 165,371 (351)

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

ANKRD49 promotes the epithelial-mesenchymal transition of non-small cell lung cancer via the PKNOX1/TGF-β1/SMAD axis. [PDF]

Cancer Cell Int
Yuan M, Qin GM, Zhang CL, Liu CF, Liang G, Sun J, Wang W, Liu KY, Yu BF, Wang HL, Pang M.   +10 more
europepmc   +1 more source

Effects of sulpiride on mRNA and protein expression of factors in the YAP-TGF-β-Smad signaling pathway in ARPE-19 cells.

Jing Fan (149601), Qiujin Zhang (472724), Liu Zheng (1880860), Binbin Yang (2259313), He Jin (12261804), Tingyu Meng (22560141), Zhixiang Ding (15349443)   +6 more
openalex   +1 more source

Potential role of transforming growth factor‐beta 1/Smad signaling in secondary lymphedema after cancer surgery [PDF]

, 2020
Masaki Sano, Satoshi Hirakawa, Minoru Suzuki, Jun‐ichi Sakabe, Mikako Ogawa, Seiji Yamamoto, Takanori Hiraide, Takeshi Sasaki, Naoto Yamamoto, Kazunori Inuzuka, Hiroki Tanaka, Takaaki Saito, Ryota Sugisawa, Kazuto Katahashi, Tatsuro Yata, Takafumi Kayama, Tetsumei Urano, Y. Tokura, Kohji Sato, Mitsutoshi Setou, Hiroya Takeuchi, Hiroyuki Konno, Naoki Unno   +22 more
openalex   +1 more source

Spatial multi‐omics identifies a NOTCH3‐mediated capillary–mCAF crosstalk driving immune exclusion in hepatocellular carcinoma

iMeta, EarlyView.
Spatial multi‐omics defines a DLL4–NOTCH3–driven capillary–mCAF axis orchestrating fibrotic remodeling and immune exclusion in hepatocellular carcinoma tumor cores, conferring immune checkpoint blockade resistance. Targeting stromal NOTCH3 disrupts this pro‐fibrotic niche, enhances T cell infiltration, and synergizes with anti‐PD‐1 therapy ...
Fansen Ji, Haochen Li, Qi Wang, Xiaojuan Wang, Jiawei Zhang, Ying Xiao, Huan Li, Hao Liu, Tanqing Long, Boyang Wu, Hao Chen, Haoming Xia, Xinquan Liu, Chuanrui Xu, Yibo Gao, Bingjun Tang, Juan Liu, Shizhong Yang, Jiahong Dong   +18 more
wiley   +1 more source

TMEM176B Prevents and alleviates bleomycin-induced pulmonary fibrosis via inhibiting transforming growth factor β-Smad signaling [PDF]

Ziwei Wang, Hehua Zhao
openalex   +1 more source

The role of FGF9-mediated TGF-β1/Smad signaling in enamel hypoplasia induced by exposure to fluoride and SO2 in rats

, 2023
Ying Lv, Yang Wang, Yao Jin, Jiaojiao He, Changhu Lin, Guohui Bai, Chenglong Tu   +6 more
openalex   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

EWSR1 as a regulatory target in hepatic stellate cell apoptosis and liver fibrosis therapy. [PDF]

Biochem Biophys Rep
Shiwan Z, Guangcheng L, Abdul Mutalib M.
europepmc   +1 more source

Image 1_Investigating the regulation of the miR-199a-3p/TGF-β/Smad signaling pathway by BSHXF drug-containing serum combined with ADSCs for delaying intervertebral disc degeneration.tif

Enxu Liu (21190403), Yu Sun (18463), Lei Yang (102719), Haobo Jiang (47337), Fei Sun (102854), Long Chen (315739), Jiahao Duan (10014005), Shaofeng Yang (1297038)   +7 more
openalex   +1 more source