Results 131 to 140 of about 77,825 (245)

Inflammatory Bowel Disease: Mechanisms and Therapeutic Advances

MedComm, Volume 7, Issue 9, September 2026.
Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is a rising, multifactorial chronic disorder driven by dysregulated mucosal immunity in genetically susceptible individuals and influenced by environmental and microbial factors.
Andrea Papait, Anna Cargnoni, Franco Scaldaferri, Loris Lopetuso, Antonietta Rosa Silini, Ornella Parolini   +5 more
wiley   +1 more source

Fisetin alleviates pulmonary arterial hypertension by inhibiting the TGF-β1/Smad 2/3 signaling pathway. [PDF]

Saudi Pharm J
Xu Y, Kang S, Gong X, Yuan Y.
europepmc   +1 more source

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

E3 ligase SMURF2 promotes adipogenesis and improves obesity complications by suppressing TGF-β signaling. [PDF]

J Lipid Res
Wu X, Wu M, Du S, Liu J, Wang R, Sun Y, Zheng Z, Yang J, Jia X, Wang L, Lu T, Yang C, Gao Y, Fang D.   +13 more
europepmc   +1 more source

Therapeutic targeting of bleomycin‐induced pulmonary fibrosis by human bone marrow mesenchymal stem cell‐derived extracellular vesicles and/or pirfenidone: Impact of sex in mature adult mice

British Journal of Pharmacology, Volume 183, Issue 18, Page 5423-5439, September 2026.
Abstract Background and Purpose Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with limited therapeutic options. This study compared the therapeutic effects of bone marrow mesenchymal stem cell‐derived extracellular vesicles (BM‐MSC‐EVs) with an IPF treatment, pirfenidone (PFD), in mature adult mice with established pulmonary ...
Jennie S. Charoenphannathon, Simon G. Royce, Yasmin Higham, Jane E. Bourke, Chrishan S. Samuel   +4 more
wiley   +1 more source

JNK inhibitor SP600125 alleviates TGF-β2-induced epithelial-mesenchymal transition in RPE cell <i>via</i> TGF-βR2/Smad2/3 and JNK/c-Jun pathway. [PDF]

Int J Ophthalmol
Zhang HH, Zhu YS, Guo JY, Chen XD.
europepmc   +1 more source

Type B Aortic Dissection Following Abdominal Aortic Aneurysm Repair in Loeys-Dietz Syndrome: A Novel <i>TGFBR1</i> Variant. [PDF]

Hum Mutat
Zhang Y, Qiu S, Hu C, Zhang L, Guo W, Fu W, Wang L.   +6 more
europepmc   +1 more source

Small Extracellular Vesicles‐Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer

Advanced Science, Volume 13, Issue 43, 3 August 2026.
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang, Xueyan Zang, Dongli Wang, Rong Li, Hui Qian, Wenrong Xu, Jiajia Jiang, Yongmin Yan   +7 more
wiley   +1 more source

MMP9 regulates osteogenesis and MMP2 expression through the TGF-β1/SMAD2/3 signaling pathway in lipopolysaccharide-induced osteoblasts. [PDF]

Braz J Med Biol Res
Li L, Yang Y, Lu X, Li H.
europepmc   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, Volume 13, Issue 43, 3 August 2026.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source