Results 141 to 150 of about 77,825 (245)

Iminostilbene, a Carbamazepine Intermediate, Alleviates Myocardial Fibrosis after Myocardial Infarction via Targeting Galectin3. [PDF]

ACS Pharmacol Transl Sci
Li N, Zhou J, Wang Z, Wang M, Tian Y, Sun G.   +5 more
europepmc   +1 more source

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, Volume 13, Issue 44, 7 August 2026.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

Optimized Aqueous Sedimentation for Methoxyflavone Enrichment from <i>Kaempferia parviflora</i> and Its Mechanistic Suppression of Benign Prostatic Hyperplasia via TGF-β/SMAD/ERK Signaling. [PDF]

ACS Omega
Boonsom T, Uttarawichien T, Nalinratana N, Darai N, Rungrotmongkol T, Rattanakrajang P, Zierau O, Kengtong S, Towiwat P, Sukrong S.   +9 more
europepmc   +1 more source

MicroRNAs in Spinal Cord Injury: Molecular and Translational Insights

Brain and Behavior, Volume 16, Issue 8, August 2026.
MicroRNAs (miRNAs) modulate secondary injury cascades following spinal cord injury (SCI), including inflammation, oxidative stress, apoptosis, and demyelination. Key miRNAs such as miR‐21, miR‐124, miR‐219, and miR‐223 exert neuroprotective effects by regulating astrocytic response, axon regeneration, and remyelination.
Seyyedeh Fahimeh Talebi, Hossein Kalarestaghi, Ehsan Sheikh Hesabi, Saeed Vafaei‐Nezhad   +3 more
wiley   +1 more source

Collagen remodeling drives continence recovery: radiofrequency therapy ameliorates SUI via TGF-β1/Smad2 pathway activation - evidence from a rat model. [PDF]

Lasers Med Sci
Zhu L, Zhou Y, Tong Y, Zhou C, Jiang L, Li X.   +5 more
europepmc   +1 more source

SMAD4 Expression and Its Association With Treatment Resistance and Clinical Outcomes in Oral Squamous Cell Carcinoma Treated With Preoperative Chemoradiotherapy

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Small mothers against decapentaplegic homologue 4 (SMAD4) plays an important role in transforming growth factor (TGF)‐β signaling and is associated with various cancers. However, little is known about SMAD4 expression in oral squamous cell carcinoma (OSCC).
Junki Sakata, Akiyuki Hirosue, Ryoji Yoshida, Yuichiro Matsuoka, Yusei Todoroki, Hidetaka Arita, Hikaru Nakashima, Tatsuro Yamamoto, Nozomu Takahashi, Masatoshi Hirayama, Kenta Kawahara, Ryo Toya, Ryuji Murakami, Takaaki Ito, Yoshikazu Kuwahara, Hideki Nakayama   +15 more
wiley   +1 more source

THBS4 Regulates Pulmonary Hypertension via TGF-β/SMAD2 Signaling. [PDF]

Hypertension
Zeng J, Li D, Wang J, Wang R, Huang Z, Bai D, Liu X, Sun D, Fu G, Kang K, Liu X, Yang L, Zhao F, Luo L, Li R, Zhang Y, Gou D.   +16 more
europepmc   +1 more source

Cholesterol Drives IFITM3+ Microglia Activation and Induces STING Mediated Neuroinflammation After Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
After ischemic stroke, cholesterol accumulation in microglia is accompanied by the emergence of a pro‐inflammatory IFITM3+ subset with aberrant esterification and lipid droplet buildup. This metabolic stress is linked to mitochondrial dysfunction, STING activation, sustained neuroinflammation, and white matter injury.
Yue Cheng, Yuxi Zhou, Yonghui Chen, Tianni Shen, Yan Li, Chen Chen, Qiuyue Fan, Jie Qi, Peiying Li, Yueman Zhang   +9 more
wiley   +1 more source

Versatile SMAD2 and SMAD3 epitope-tagged mouse models for genomic profiling of TGFβ signaling: Uncovering GDF9-SMAD2/3 targets. [PDF]

Proc Natl Acad Sci U S A
Liao Z, Zhang Q, Shimada K, Nozawa K, Tang S, Ikawa M, Monsivais D, Matzuk MM.   +7 more
europepmc   +1 more source

Vorinostat Mitigates Early Brain Injury Following Subarachnoid Hemorrhage Through Modulation of the C3aR1/TGF‐β/Smad Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
C3aR1 mediates microglial activation after SAH in part through the TGF‐β/Smad signaling pathway. Vorinostat alleviates early brain injury after SAH by reducing C3aR1 levels. ABSTRACT Background Excessive microglial activation after subarachnoid hemorrhage (SAH) contributes to early brain injury (EBI) and poor clinical outcomes.
Chonghui Zhang, Yifan Xu, Junshan Wan, Jinpeng Wu, Chao Wang, Yugong Feng   +5 more
wiley   +1 more source