Results 161 to 170 of about 77,825 (245)

Hyperlipidemia-induced metabolic dysregulation impairs tendon homeostasis: the role of TGF-<i>β</i>/Smad2 signaling pathway in lipid-mediated extracellular matrix remodeling. [PDF]

Front Med (Lausanne)
Shang P, Li R, Xia Y, Wang Z, Yang R, Fu Q.   +5 more
europepmc   +1 more source

Ginseng as a Functional Food Intervention for Interstitial Lung Disease: A Review of the Benefits and Molecular Mechanisms

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
From the perspectives of food science and nutrition, this article reviews the regulatory mechanisms through which ginseng and its major components influence ILD‐related pathological processes and discusses its potential as a functional food and future research directions. ABSTRACT Interstitial lung disease (ILD) encompasses a complex group of disorders
Jiahui Li, Guixin Di, Haijiao Wang, Mengzhu Chen, Keju Wang, Ziyuan Wang, Yanxin Li, Tan Wang   +7 more
wiley   +1 more source

Post-transcriptional activation of TGF-β signaling via SMAD mRNA stabilization by EIF4A3 promotes EMT and metastasis in gastric cancer. [PDF]

Cell Biol Toxicol
Liu Y, Zhang Y, Dou W, Peng W, Cheng M, Zhou Y, Shao Q, Wu Y.   +7 more
europepmc   +1 more source

Effects of Naringenin on Diabetic Nephropathy: A Systematic Review and Meta‐Analysis of Rodent Studies

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Naringenin produces comprehensive renoprotective effects in rodent models of diabetic nephropathy. It mainly lowers blood sugar and alleviates renal dysfunction by reducing proteinuria, serum creatinine, and blood urea nitrogen. Meanwhile, naringenin improves antioxidant status by elevating glutathione and reducing malondialdehyde, and suppresses ...
Yuzhu Qu, Jie Chen, Ling Yue, Xinyue Zhang, Kongmei Ou, Yiting Wang, Runjia He, Benxiang He   +7 more
wiley   +1 more source

A Novel Anti-Fibrotic Role of G-Protein-Coupled Receptor 119 in Hepatic Stellate Cells. [PDF]

Biomol Ther (Seoul)
Park J, Lee MH, Kim HY, Kim HS, Kim SK, Yang JW, Kang KW.   +6 more
europepmc   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Advances in Pharmacological Therapy of Benign Tracheal Stenosis: A Meta‐Analysis of Preclinical Studies

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 4, August 2026.
ABSTRACT Background Benign tracheal stenosis, characterized by granulation hyperplasia, is a rare and serious disease threatening human health. Interventional bronchoscopy demonstrates limited therapeutic efficacy and poses a risk of re‐injury to the airway.
Dengyuan Li, Jie Zeng, Rufang Li, Rong Wang, Danxiong Sun   +4 more
wiley   +1 more source

Tumor Plasticity and Microenvironmental Crosstalk as Drivers of Metastasis and Therapy Resistance

MedComm, Volume 7, Issue 8, August 2026.
The graphical abstract is a schematic illustration of the bidirectional crosstalk between tumor plasticity and the tumor microenvironment (TME) in driving metastasis and therapy resistance. Tumor‐intrinsic factors such as genetic mutations and epigenetic reprogramming enable dynamic transitions between epithelial, mesenchymal, and cancer stem cell ...
Gunjan Dagar, Manisha Dagar, Ashna Gupta, Anju Surendranath, Suraja Kumar Das, Mohd Umar Rehmani, Mukesh Tanwar, Sameer Mirza, Muzafar A. Macha, Ammira S. Al‐Shabeeb Akil, Shahab Uddin, Mayank Singh, Ajaz A. Bhat   +12 more
wiley   +1 more source

Cardiomyocyte-derived BDNF restricts cardiac fibrosis by decreasing the activity of the TGF-β/Smad2/3 pathway and increasing Smad7 expression. [PDF]

Front Cell Dev Biol
Zhu Y, Ran Y, Fu T, Zheng X, Chen Y, Liang C, Li Y, Huang R, Zhao H, Pan X, Yuan Z, Pu Q, Zeng Z, Feng S, Qi X, Lv L, Zhan L, Chen Y, Cai D.   +18 more
europepmc   +1 more source

Direct inhibition of the transforming growth factor-β pathway by protein-bound polysaccharide through inactivation of Smad2 signaling

Direct inhibition of the transforming growth factor-β pathway by protein-bound polysaccharide through inactivation of Smad2 signaling
Transforming growth factor-β (TGF-β) is involved in the regulation of cell proliferation, differentiation, and apoptosis and is associated with epithelial-mesenchymal transition (EMT). Inhibition of the TGF-β pathway is an attractive strategy for the treatment of cancer. We recently screened for novel TGF-β inhibitors among commercially available drugs
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