Results 181 to 190 of about 77,825 (245)

Conjunctival Sac‐Derived Lactobacillus mucosae MM‐1 Metabolite Indole‐3‐Lactic Acid Attenuates Lens‐Induced Myopia in Mice via AHR Activation and TGF‐β/Smad Inhibition

Microbial Biotechnology, Volume 19, Issue 8, August 2026.
This study proposes a ‘conjunctival sac microecology‐metabolite‐scleral remodelling’ regulatory axis, highlighting the potential role of conjunctival sac microbiota in maintaining ocular surface health and regulating lens‐induced myopia in mice, providing an important theoretical foundation for the development of microbiome‐based interventions for ...
Yanqing Li, Qiuyu Wu, Xilong Zhang, Luchuan Liu, Leiping Ding, Jingjing Xu, Chiwen Cheng, Yangyang Peng, Kang Yu, Wen Yao, Yijie Pi, Jiale Li, Di Wu, Jing Wei, Yifeng Yu, Tingtao Chen   +15 more
wiley   +1 more source

Ovarian Extracellular Matrix Mechanics Regulate Oocyte‐Follicle Interactions During Female Reproductive Aging

Aging Cell, Volume 25, Issue 8, August 2026.
Hydrogel culture mimicking young and aged ovarian stromal stiffness recapitulates key features of reproductive aging, including impaired follicle growth, transzonal projections (TZPs), and oocyte quality. Silencing Smad7 rescues TZPs and oocyte quality in stiff hydrogels, identifying ECM mechanics as a driver and therapeutic target in ovarian aging ...
Xingyu Shen, Haiyang Wang, Gefei Cao, Yaelim Lee, Jin Zhu, Loo Chien Wang, Tianyun Zhao, Siok Ghee Ler, Radoslaw M. Sobota, Rong Li, Jennifer L. Young   +10 more
wiley   +1 more source

Targeting ADAMTS1/HDAC6 alleviates TGF-β1/SMAD2-associated cardiac fibrosis in cardiac fibrosis post-myocardial infarction. [PDF]

Cell Biol Toxicol
Jin Q, Chen C, Wu P, Li L, Jiang L, Chen R, Xu S, Huang Y, Xu H, Long X.   +9 more
europepmc   +1 more source

Neurokinin‐1 receptor activation protects against cardiac fibrosis, inflammation and diastolic dysfunction in type 2 diabetic mice

British Journal of Pharmacology, Volume 183, Issue 15, Page 4246-4266, August 2026.
Background and Purpose The pathogenesis of type 2 diabetes mellitus (T2DM)‐induced cardiomyopathy involves cardiac fibrosis that leads to diastolic dysfunction. We established that replacement of lost substance P (SP) that occurs in T2DM reduces cardiac fibrosis and decreases inflammation in T2DM mice and non‐human primates.
Alexander Widiapradja, Heather Connery, Brody J. Helmick, Kallie J. Schafner, Vamsi Manchikalapudi, Hannah Horvath, Sophia Gugino, Tamas Kriska, Anja Herrnreiter, Evan DeVallance, William B. Campbell, Scott P. Levick   +11 more
wiley   +1 more source

Effect of peritoneal dialysate on peritoneal fibrosis. [PDF]

BMC Nephrol
Dai Z, Zhou F, Li M, Lin H, Sheng Q, Luo Q.   +5 more
europepmc   +1 more source

Application of Systems Genetics to Investigate Molecular Pathology of Early‐Onset Colorectal Cancer

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
Early‐onset colorectal cancer (EOCRC) presents a complex molecular landscape that requires integrated multi‐omics approaches. This article reviews current applications of systems genetics in EOCRC research and provides a step‐by‐step protocol for network‐based analyses featuring PIK3CA to demonstrate practical application for researchers of all levels.
Minjae J. Kim, Sydney L. Carr, Vishnutheertha Kulkarni, Mary‐Louise Manchadi   +3 more
wiley   +1 more source

ISG15 deficiency in hepatic stellate cells promotes TGFβ2-induced liver fibrosis by counteracting CREB1 ISGylation. [PDF]

Gut
Yuan Y, Li J, Rao D, Lu X, Chen M, Chen X, Long X, Zhang B, Liang H, Chen Q, Zhao J.   +10 more
europepmc   +1 more source

Hepatocyte TrkB Acts as a Gatekeeper Against MASH‐Related Liver Fibrosis by Suppressing the TGFβ/CCL2 Axis and Macrophage Infiltration

Cell Proliferation, Volume 59, Issue 8, August 2026.
Hepatocyte TrkB is identified as a critical gatekeeper against MASH‐related fibrosis. Mechanistically, TrkB inhibits the TGFβ/SMAD3/FOS axis to suppress CCL2 secretion, thereby blocking pathogenic macrophage recruitment and ameliorating liver fibrosis.
Yueying Chen, Jiayi Wei, Shuxuan Li, Kefan Yin, Heming Wang, Yicheng Zhao, Shuqiang Weng, Xizhong Shen, Guangqi Song, Changfeng Zhu, Qunyan Yao, Ling Dong   +11 more
wiley   +1 more source

Activin A-Endothelin-1 Axis Governs Pulmonary Vascular Remodeling: Mechanistic Basis for Emerging Therapies in PAH. [PDF]

Arterioscler Thromb Vasc Biol
Faizah NN, Ryanto GRT, Kencana SMS, Suzuki Y, Hara T, Otake H, Emoto N.   +6 more
europepmc   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, Volume 59, Issue 8, August 2026.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source