Results 41 to 50 of about 5,655,190 (291)
Антибиотики и Химиотерапия, 2020 The article describes different generations of antisense oligonucleotids (unmodified oligonucleotids, phosphorothioate oligomers, 2’-0-methyl and 2’-0-methoxy-ethyl modification of oligomers, phosphordiamidate morpholine oligomers and small interfering ...
A. A. Petrov +4 more
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Small RNAs: An expanding world with therapeutic promises
Fundamental Research, 2023 Small non-coding RNAs (sncRNAs), such as microRNAs (miRNAs), small interfering RNAs (siRNAs), PIWI-interacting RNAs (piRNAs), and transfer RNA (tRNA)-derived small RNAs (tsRNAs), play essential roles in regulating various cellular and developmental ...
Lan-Tao Gou, Qifan Zhu, Mo-Fang Liu
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Antitumor effects of small interfering RNAs
Медицинская иммунологияThe aim of our work was to summarize the existing results in anticancer therapy with small interfering RNAs (siRNAs), as well as to highlight the role of siRNA as a remodulator of the immune response in oncological diseases.
E. A. Pashkov +5 more
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Functional diversification of Argonautes in nematodes:an expanding universe [PDF]
, 2013 In the last decade, many diverse RNAi (RNA interference) pathways have been discovered that mediate gene silencing at epigenetic, transcriptional and post-transcriptional levels. The diversity of RNAi pathways is inherently linked to the evolution of Ago
Buck, Amy H, Blaxter, Mark
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Hfq binding changes the structure of Escherichia coli small noncoding RNAs OxyS and RprA, which are involved in the riboregulation of rpoS [PDF]
, 2013 : OxyS and RprA are two small noncoding RNAs (sRNAs) that modulate the expression of rpoS, encoding an alternative sigma factor that activates transcription of multiple Escherichia coli stress-response genes.
Taylor, James E. +28 more
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Application of RNA interference technology in pest control and its safety
浙江大学学报. 农业与生命科学版, 2022 RNA interference (RNAi) is a highly conserved gene-silencing phenomenon, induced by 20-30 nucleotide (nt) small molecules of non-coding RNA in vivo. Three non-coding RNAs, such as small interfering RNA (siRNA), microRNA (miRNA) and PIWI-interacting RNA ...
WANG Fang +7 more
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The specifics of small interfering RNA specificity [PDF]
Proceedings of the National Academy of Sciences, 2003 The discovery of transgene silencing in plants and double-stranded RNA (dsRNA) interference in the worm Caenorhabditis elegans has led to the latest revolution in molecular biology, RNA interference (RNAi). Over 10 years ago it was noted that several transgenic plant lines each containing the same ectopic transgene not only failed to be expressed but ...
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, 2010 Plant small RNAs are a class of 19- to 25-nucleotide (nt) RNA molecules that are essential for genome stability, development and differentiation, disease, cellular communication, signaling, and adaptive responses to biotic and abiotic stress.
Hellens, R.P. +3 more
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Effect of small interfering RNAs on matrix metalloproteinase 1 expression
Biotechnology Reports, 2014 Three small double strand siRNAs (506-MMP1, 859-MMP1 and 891-MMP1), each contains 25–26 nucleotides, with high specific to human MMP1 were designed according to mRNA sequence of human MMP1 (NCBI, NM_002421). To monitor the MMP1 gene expression, the total
Gen-Hung Chen +3 more
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Computational discovery of animal small RNA genes and targets [PDF]
, 2007 Though recently discovered, small RNAs appear to play a wealth of regulatory roles, being involved in degradation of target mRNAs, translation silencing of target genes, chromatin remodeling and transposon silencing.
Gaidatzis, Dimosthenis
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