Results 31 to 40 of about 5,655,190 (291)

Novel Cell type-specific aptamer-siRNA delivery system for HIV-1 therapy [PDF]

, 2007
The successful use of small interfering RNAs (siRNAs) for therapeutic purposes requires safe and efficient delivery to specific cells and tissues. Here we demonstrate cell type-specific delivery of anti-HIV siRNAs via fusion to an anti-gp120 aptamer. The
Haitang Li, John Zaia, John Rossi, Jiehua Zhou, Shirley Li   +4 more
core   +1 more source

Diverging affinity of tospovirus RNA silencing suppressor proteins, NSs, for various RNA duplex molecules [PDF]

, 2010
The tospovirus NSs protein was previously shown to suppress the antiviral RNA silencing mechanism in plants. Here the biochemical analysis of NSs proteins from different tospoviruses, using purified NSs or NSs containing cell extracts, is described.
Kormelink, R.J.M., Rik Huismann, Esther Schnettler, Rob Goldbach, Goldbach, R., Marcel Prins, Goldbach, R.W., Kormelink, R., Hemmes, H., Prins, M., Huismann, R., Hans Hemmes, Huisman, R., Hemmes, J.C., Schnettler, E., Richard Kormelink, Prins, M.W.   +16 more
core   +1 more source

INTEGRATIVE COMPUTER ANALYSIS OF ANTISENSE TRANSCRIPTS AND miRNA TARGETS IN PLANT GENOMES [PDF]

Journal of Stress Physiology & Biochemistry, 2012
Non-coding RNA, including small interfering RNAs (siRNAs), are important components of gene expression in eukaryotes, forming a regulatory network. miRNAs are expressed through nucleolytic maturation of hairpin precursors transcribed by RNA Polymerase II
Orlov Y.L., O. Dobrovolskaya, C.H. Yuan, D.A. Afonnikov, Y. Zhu, M. Chen   +5 more
doaj  

Development of therapeutic-grade small interfering RNAs by chemical engineering

Frontiers in Genetics, 2012
Recent successes in clinical trials have provided important proof of concept that small interfering RNAs indeed constitute a new promising class of therapeutics.
Jesper Bertram Bramsen, Jørgen eKjems
doaj   +1 more source

Epigenetic Regulation by Non-Coding RNAs in the Avian Immune System

Life, 2020
The identified non-coding RNAs (ncRNAs) include circular RNAs, long non-coding RNAs, microRNAs, ribosomal RNAs, small interfering RNAs, small nuclear RNAs, piwi-interacting RNAs, and transfer RNAs, etc.
Xiaolan Chen, Bahareldin Ali Abdalla, Zhenhui Li, Qinghua Nie   +3 more
doaj   +1 more source

Basics of epigenetics and role of epigenetics in diabetic complications

Journal of Pharmacy and Bioallied Sciences, 2021
The term “Epigenetics” includes mechanisms by which genetic expression is altered without a change in the underlying DNA sequence. The changes caused by epigenetic mechanisms are inheritable and are one way in direction (irreversible) and also explains ...
Andamuthu Yamunadevi, Ramani Pratibha, Muthusamy Rajmohan, Sengottaiyan Mahendraperumal, Nalliappan Ganapathy   +4 more
doaj   +1 more source

RNA interference targets arbovirus replication in Culicoides cells [PDF]

, 2013
Arboviruses are transmitted to vertebrate hosts by biting arthropod vectors such as mosquitoes, ticks and midges. These viruses replicate in both arthropods and vertebrates and are thus exposed to different antiviral responses in these organisms.
Varela, Mariana, Esther Schnettler, Ratinier, Maxime, Shaw, Andrew, Palmarini, Massimo, Kohl, Alain, Mariana Varela, Mick Watson, Elliott, Richard M., Alain Kohl, Maxime Ratinier, McFarlane, Melanie, Shaw, Andrew E., Elliott, Richard, Richard M, Massimo Palmarini, Schnettler, Esther, E. Shaw, Watson, Mick, A Alain Kohla, Melanie Mcfarlane   +20 more
core   +1 more source

Rapid and efficient isolation of high-quality small RNAs from recalcitrant plant species rich in polyphenols and polysaccharides.

PLoS ONE, 2014
Small RNAs, including microRNAs (miRNAs) and small interfering RNAs (siRNAs), are important regulators of plant development and gene expression. The acquisition of high-quality small RNAs is the first step in the study of its expression and function ...
Jun Peng, Zihao Xia, Ling Chen, Minjing Shi, Jinji Pu, Jianrong Guo, Zaifeng Fan   +6 more
doaj   +1 more source

Roles of piwi-interacting RNAs and small interfering RNAs in regulating gene expression in Caenorhabditis elegans [PDF]

, 2022
2022 Spring.Includes bibliographical references.There are three distinct classes of small RNAs found in animals: microRNAs (miRNAs), piwi interacting RNAs (piRNAs), and small interfering RNAs (siRNAs).
Nishimura, Marc T, committee member, Hoerndli, Fred J., committee member, Montgomery, Taiowa A., advisor, Wilusz, Carol J., committee member, Reed, Kailee Janelle, author   +4 more
core  

Extraction of Small RNA and qPCR Validation of miRNAs in Vigna mungo

Bio-Protocol, 2015
Small RNAs like microRNAs (miRNAs), small interfering RNAs (siRNAs) and other noncoding RNAs including snRNA and snoRNA have tremendous impact on eukaryotic gene regulation.
Sujay Paul, Anirban Kundu, Amita Pal
doaj   +1 more source