Results 11 to 20 of about 5,655,190 (291)
An atlas of small RNAs from potato [PDF]
Plant Direct, 2022 Small RNAs, including microRNAs (miRNAs), phased secondary small interfering RNAs (phasiRNA), and heterochromatic small interfering RNAs (hc‐siRNA) are an essential component of gene regulation. To establish a broad potato small RNA atlas, we constructed
Patricia Baldrich +3 more
doaj +2 more sources
Therapeutic potential of small interfering RNAs/micro interfering RNA in hepatocellular carcinoma [PDF]
World Journal of Gastroenterology, 2015 Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and represents the third leading cause of cancer-related death worldwide. Current available therapeutic approaches are poorly effective, especially for the advanced forms of the disease.
FARRA, ROSSELLA +3 more
openaire +5 more sources
An endogenous small interfering RNA pathway in Drosophila [PDF]
Nature, 2008 Drosophila endogenous small RNAs are categorized according to their mechanisms of biogenesis and the Argonaute protein to which they bind. MicroRNAs are a class of ubiquitously expressed RNAs of approximately 22 nucleotides in length, which arise from structured precursors through the action of Drosha-Pasha and Dicer-1-Loquacious complexes.
Czech, Benjamin +11 more
core +7 more sources
Informatics in Medicine Unlocked, 2018 RNA silencing is a novel gene regulatory mechanism that confines the transcript level by either preventing translation or by the initiation of particular RNA degradation.
Anum Munir +7 more
doaj +2 more sources
Oncogene Suppression by Small Interfering RNAs
Current Pharmaceutical Biotechnology, 2004 Almost all human cancers have accumulated multiple genetic lesions including oncogenes. It is often unknown whether an oncogene is continuously required for tumorigenesis. Furthermore, it is very difficult to target an essential oncogene with drugs without affecting the corresponding nonmutated protooncogene or related factors.
Heidenreich O
core +6 more sources
Characterization of the small RNA transcriptome of the diatom, Thalassiosira pseudonana. [PDF]
PLoS ONE, 2011 This study presents the first characterization of endogenous small RNAs in a diatom, Thalassiosira pseudonana. Small RNAs act as transcriptional and translational regulators, controlling specific target genes involved in various cellular functions ...
Trina M Norden-Krichmar +3 more
doaj +1 more source
Precision RNAi in Tomato Using Synthetic Trans-Acting Small Interfering RNAs Derived From Minimal Precursors. [PDF]
Plant Biotechnol J[EN] RNA interference (RNAi) is a highly conserved gene silencing mechanism regulating gene expression at transcriptional and post-transcriptional levels in plants.
Tomassi AH +8 more
europepmc +2 more sources
Exploring the expanding universe of small RNAs [PDF]
, 2022 The world of small noncoding RNAs (sncRNAs) is ever-expanding, from small interfering RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs derived from longer structured RNAs (for example, transfer, ribosomal, Y, small ...
Shi, Junchao, Zhou, Tong, Chen, Qi
core +2 more sources
Noncoding RNAs and their roles in regulating the agronomic traits of crops
Fundamental Research, 2023 Molecular breeding is one of the most effective methods for improving the performance of crops. Understanding the genome features of crops, especially the physiological functions of individual genes, is of great importance to molecular breeding. Evidence
Yu-Chan Zhang, Chao Yuan, Yue-Qin Chen
doaj +1 more source
Tospoviruses Induce Small Interfering RNAs Targeting Viral Sequences and Endogenous Transcripts in Solanaceous Plants. [PDF]
Pathogens, 2022 Tospoviruses infect numerous crop species worldwide, causing significant losses throughout the supply chain. As a defence mechanism, plants use RNA interference (RNAi) to generate virus-derived small-interfering RNAs (vsiRNAs), which target viral ...
Fletcher SJ +7 more
europepmc +3 more sources