Results 101 to 110 of about 634,892 (192)

Similarities between protein folding and granular jamming. [PDF]

, 2012
Grains and glasses, widely different materials, arrest their motions upon decreasing temperature and external load, respectively, in common ways, leading to a universal jamming phase diagram conjecture.
Andricioaei, Ioan, Jose, Prasanth P
core   +1 more source

Presentation and Outcomes of CNS Tumors Associated With Phakomatoses Syndromes From a Specialized Neuro‐Oncology Practice in India

Cancer Medicine, Volume 15, Issue 2, February 2026.
Encouraging survival is achieved in phakomatosis syndromes with conventional multimodality treatment (Surgery, RT, chemotherapy). There is an urgent need for easily administered systemic therapies which improve both quality and quantity of life. ABSTRACT Purpose Phakomatoses‐associated primary central nervous system (CNS) tumors are therapeutically ...
Anuradha Krishnan, Yamini Baviskar, Abhishek Chatterjee, Archya Dasgupta, Sridhar Epari, Arpita Sahu, Girish Chinnaswamy, Nandini Menon, Aliasgar Moiyadi, Tejpal Gupta, Jayant Sastri‐Goda   +10 more
wiley   +1 more source

Characterisation of the biflavonoid hinokiflavone as a premRNA splicing modulator that inhibits SENP [PDF]

, 2017
We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule.
Abovich, Arango, Asai, Boswell, Chabot, Chen, Chiba, Cox, Cox, Cáceres, David, Ferhi, Fong, Gao, Gao, Harborne, Hendriks, Hett, Kaida, Kalva, Konarska, Kotake, Kumar, Lamond, Lamond, Larrayoz, Le, Lee, Lomenick, Makarov, Naryshkin, O'Brien, Pai, Pan, Papasaikas, Papasaikas, Pelisch, Pozzi, Rappsilber, Ratni, Sakai, Tammsalu, Tammsalu, UniProt Consortium, Wahl, Webb, Wen, Wiśniewski, Woll, Wu, Xiao, Zuo   +51 more
core   +5 more sources

Biosynthesis of Silver Nanoparticles Using Black Pepper (Piper nigrum) Seed Extract and Evaluation of Their Cytotoxicity

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
This study reports the green biosynthesis of piperine‐functionalized silver nanoparticles from Piper nigrum seed extract, followed by comprehensive physicochemical characterization and in vitro cytotoxic evaluation. The results confirm successful nanocomposite formation and demonstrate a marked enhancement of cytotoxic activity against gastric cancer ...
Nylton Ferreira Maciel, Gleice VasconcelosPereira do Lago, Glauce Vasconcelos da Silva Pereira, Ingryd Nayara de Farias Ramos, Aline Costa Bastos, Igor Alexandre Rocha Barreto, Nathiel Sarges Moraes, Marcos NazarenoLauné dos Santos, João Augusto Pereira da Rocha, Alencar Kolinski Machado, Waldomiro Gomes Paschoal Junior, Marcio Marcelo da Silva Pessoa, Maria de Nazaré Maciel Uesugi, André Salim Khayat, Jorddy Neves Cruz, José de ArimatéiaRodrigues do Rêgo, Maria Regina Sarkis Peixoto Joele, Davi do Socorro Barros Brasil   +17 more
wiley   +1 more source

UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy [PDF]

, 2018
Deafferentation of motor neurons as a result of defective sensory-motor connectivity is a critical early event in the pathogenesis of spinal muscular atrophy, but the underlying molecular pathways remain unknown.
Boyd, Penelope J., Gillingwater, Thomas H., Groen, Ewout J. N., Lamont, Douglas J., Llavero Hurtado, Maica, Schiavo, Giampietro, Shorrock, Hannah K., Sleigh, James N., van der Hoorn, Dinja, Wirth, Brunhilde, Wishart, Thomas M.   +10 more
core   +4 more sources

Progress in RNA‐Targeted Therapeutics for Human Diseases

MedComm, Volume 7, Issue 2, February 2026.
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang, Aimin Jiang, Bin‐Kui Jia, Yuming Jin, Yinghu Chen, Zhaoyu Li, Yan Liao, Haoling Zhang, Zhiheng Lin, Xiao Fang, Linhui Wang   +10 more
wiley   +1 more source

Integrated genomic and transcriptomic analyses of radiation-induced malignancies [PDF]

, 2016
Cancer is a genetic disease caused by an unregulated expansion of a clone of cells (Sompayrac, 2004). The genetic abnormalities in cancer are the consequences of defective DNA replication, repair, maintenance, and modification, genetic background, and ...
Lee, Yong Eun
core   +1 more source

Essential Protein Factors in pre-mRNA splicing : A Structural Study by Nuclear Magnetic Resonance Spectroscopy [PDF]

, 2002
This thesis describes two novel three-dimensional structures and the functional characterization of proteins that play important roles in eukaryotic RNA splicing.
Selenko, Philipp
core   +1 more source

Spinal Muscular Atrophy Carrier Screening: Assessment of Provider Knowledge and Clinical Practice

Prenatal Diagnosis, Volume 46, Issue 2, Page 229-235, February 2026.
ABSTRACT Objective The American College of Obstetricians and Gynecologists (ACOG) recommends offering spinal muscular atrophy (SMA) carrier screening (CS) preconception or prenatally. This study aimed to determine provider knowledge of SMA and SMA CS practice patterns and to describe the relationship between knowledge and comfort while discussing ...
Melissa Riegel, Whitney Bender, Elizabeth Critchlow, Lorraine Dugoff   +3 more
wiley   +1 more source

Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cγ governs Cajal body localization and stability of the SMN complex

Journal of Cell Biology, 2007
The survival motor neuron (SMN) complex functions in maturation of uridine-rich small nuclear ribonucleoprotein (RNP) particles. SMN mediates the cytoplasmic assembly of Sm proteins onto uridine-rich small RNAs, and then participates in targeting RNPs to
Sebastian Petri, M. Grimmler, S. Over, U. Fischer, O. Gruss   +4 more
semanticscholar   +1 more source