Results 61 to 70 of about 9,361 (152)

Integrated genomic and transcriptomic analyses of radiation-induced malignancies [PDF]

, 2016
Cancer is a genetic disease caused by an unregulated expansion of a clone of cells (Sompayrac, 2004). The genetic abnormalities in cancer are the consequences of defective DNA replication, repair, maintenance, and modification, genetic background, and ...
Lee, Yong Eun
core   +1 more source

piRNA processing within non‐membrane structures is governed by constituent proteins and their functional motifs

The FEBS Journal, Volume 292, Issue 11, Page 2715-2736, June 2025.
The silencing of transposable elements is mediated by piRNAs through post‐transcriptional and transcriptional regulation. In Drosophila, piRNAs are processed within unique non‐membrane structures: nuage in germline cells and Yb bodies in somatic gonadal cells.
Ritsuko Suyama, Toshie Kai
wiley   +1 more source

Phosphatase and tensin homologue: a therapeutic target for SMA [PDF]

, 2017
Spinal muscular atrophy (SMA) is one of the most common juvenile neurodegenerative diseases, which can be associated with child mortality. SMA is caused by a mutation of ubiquitously expressed gene, Survival Motor Neuron1 (SMN1), leading to reduced SMN ...
AH Burghes, AK Bevan, AS Arnold, B Trulzsch, C Carissimi, C Simone, CJ DiDonato, CL Lorson, CR Heier, D Buhler, D Little, D Sareen, DJ Freeman, DJ Yang, E Hajduch, ER Hollis 2nd, G Battaglia, G Hamilton, H Liu, H Rindt, HL Zhang, HM Hsieh-Li, HR Fuller, I Tein, J Branchu, J Gu, J Pearn, J Peltier, J Ramser, J Yong, JC Chang, JH Chung, JH Pearn, JO Lee, JR Bach, JV McGivern, K Bilguvar, K Liu, K Ning, KD Foust, KK Park, L Cartegni, L Schnell, L Schnell, L Van Den Bosch, L Viollet, LC Trotman, M Azzouz, M Bowerman, M Bowerman, MB Lachyankar, MM Martin, N Roy, ND Mazarakis, NK Genabai, RA Powis, S Jablonka, S Lefebvre, S Lefebvre, S Majumder, S Rudnik-Schoneborn, S Shanmugarajan, S Zhang, T Baughan, TM Wishart, TW Prior, U Felderhoff-Mueser, UR Monani, V Stambolic, W Rossoll, Y Zhang, Y Zhu, ZY Cheng   +72 more
core   +1 more source

ALKBH3‐Mediated M1A Demethylation of METTL3 Endows Pathological Fibrosis:Interplay Between M1A and M6A RNA Methylation

Advanced Science, Volume 12, Issue 19, May 22, 2025.
RNA modification is crucial in fibrosis diseases, but the role of m1A modification remains elusive. This study reveals that ALKBH3, an m1A demethylase, drives skin fibrosis by reshaping m6A RNA modification and stabilizing COL1A1 and FN1 mRNAs through METTL3, uncovering a crosstalk between m1A and m6A methylation in pathological events.
Liying Tu, Shuchen Gu, Ruoqing Xu, En Yang, Xin Huang, Hsin Liang, Shenying Luo, Haizhou Li, Yixuan Zhao, Tao Zan   +9 more
wiley   +1 more source

Enhanced expression of the central survival of motor neuron (SMN) protein during the pathogenesis of osteoarthritis [PDF]

, 2015
The identification of new components implicated in the pathogenesis of osteoarthritis (OA) might improve our understanding of the disease process.
Cucchiarini, Magali, Madry, Henning, Terwilliger, Ernest F   +2 more
core   +1 more source

Harnessing the Power of Marine Biomass‐Derived Carbon for Electrochemical Energy Storage

Battery Energy, Volume 4, Issue 3, May 2025.
Marine biomass is considerably a promising option for extracting carbon materials. Unlike other biomass, its chemical composition facilitated the power of EES devices. This review especially highlighted the efficacy of marine biomass‐derived carbon extracted from a variety of marine algae, fish waste, and skeletons of marine creatures on batteries and ...
Protity Saha, Md. Zahidul Islam, Syed Shaheen Shah, M. Nasiruzzaman Shaikh, T. Maiyalagan, Md. Abdul Aziz, A. J. Saleh Ahammad   +6 more
wiley   +1 more source

WRAP53 Unwrapped; Roles in Nuclear Architecture and Cancer [PDF]

, 2011
WRAP53 is a gene of multiple functions; it encodes for a natural antisense transcript that regulates the actions of the tumour suppressor p53, and it gives rise to a protein with oncogenic properties that is important for Cajal body formation and ...
Mahmoudi, Salah
core   +1 more source

Safety of the Selective JAK1 Inhibitor Oclacitinib in Dogs

Journal of Veterinary Pharmacology and Therapeutics, Volume 48, Issue 3, Page 135-145, May 2025.
ABSTRACT Apoquel(oclacitinib maleate) as a film‐coated tablet, a selective Janus kinase (JAK)1 inhibitor, was approved by the United States Food and Drug Administration (FDA) in 2013 for the control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.
Steven M. Nederveld, Matthew J. Krautmann, John Mitchell   +2 more
wiley   +1 more source

Conserved requirement for DEAD-box RNA helicase Gemin3 in Drosophila oogenesis [PDF]

, 2012
Background: DEAD-box RNA helicase Gemin3 is an essential protein since its deficiency is lethal in both vertebrates and invertebrates. In addition to playing a role in transcriptional regulation and RNA silencing, as a core member of the SMN (survival of
Cauchi, Ruben J.
core   +3 more sources

Current State‐Of‐Play of the EU Advanced Therapy Medicinal Product (ATMP) Field, With an Emphasis on Belgian Human Cell and Tissue Products

Wound Repair and Regeneration, Volume 33, Issue 3, May/June 2025.
ABSTRACT The late 1980s saw the emergence of experimental therapies based on human cell and tissue products (HCTPs) within academic and hospital settings, several of them wound healing related. In 2008, the European Commission introduced the Regulation on advanced therapy medicinal products (ATMPs), defining many of these HCTPs as ATMPs, and more ...
Gilbert Verbeken, Lieke Convents, Nicolas Delmotte, Jean‐Pierre Draye, Serge Jennes, Alain Vanderkelen, Griet Nijs, Philippe Lewalle, Etienne Baudoux, Olivier Cornu, Ineke Vanlaere, Anne Pierlot, Thomas Rose, Jean‐Paul Pirnay   +13 more
wiley   +1 more source