Results 71 to 80 of about 9,361 (152)

Molecular medicine of microRNAs: structure, function and implications for diabetes [PDF]

, 2008
MicroRNAs (miRNAs) are a family of endogenous small noncoding RNA molecules, of 19–28 nucleotides in length. In humans, up to 3% of all genes are estimated to encode these evolutionarily conserved sequences.
Duncan, Erica Hennessy, Lorraine O'Driscoll, Offield, Schleicher, Zhou   +5 more
core   +1 more source

Impacts of perinatal nicotine exposure on nicotinic acetylcholine receptor expression and glutamatergic synaptic transmission in the mouse auditory brainstem

The Journal of Physiology, Volume 603, Issue 9, Page 2857-2876, 1 May 2025.
Abstract figure legend Developmental nicotine exposure is known to cause a myriad of health defects including auditory processing deficits. In human and animal studies, nicotine exposure can lead to impaired auditory temporal processing and disrupted glutamate synapse development within the auditory cortex.
Mackenna Wollet, Abram Hernandez, Kaila Nip, Brett Ginsburg, Jason R. Pugh, Jun Hee Kim   +5 more
wiley   +1 more source

A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II [PDF]

, 2014
Cajal bodies are nuclear structures that are involved in biogenesis of snRNPs and snoRNPs, maintenance of telomeres and processing of histone mRNA. Recently, the SUMO isopeptidase USPL1 was identified as a component of Cajal bodies that is essential for ...
Andersen, Baillat, Bauer, Blencowe, Boisvert, Boulisfane, Broome, Campion, Carmo-Fonseca, Chen, Cioce, Collier, Cox, Cox, Cuello, Darzacq, Dundr, Durocher, Egloff, Fischer, Fischer, Fischer, Fischer, Frey, Gabanella, Ganot, Gao, Hamm, Handwerger, Hegele, Hu, Huang, Huang, Hutten, Jacobs, Jao, Jawdekar, Jády, Kambach, Kiss, Kiss, Klingauf, Kunkel, Lange, Lemm, Lindgren, Listerman, Liu, Machyna, Makarov, Mao, Massenet, Matera, Matera, Mattaj, Medlin, Meulmeester, Morris, Mouaikel, Novotný, O'Keefe, Ong, Ong, Patel, Pellizzoni, Plessel, Polak, Raška, Reddy, Sauterer, Schaffert, Schulz, Shav-Tal, Shevchenko, Sleeman, Sleeman, Smith, Smith, Sowa, Spector, Spector, Spector, Spector, Stanek, Stanek, Strzelecka, Taneja, Tucker, Tycowski, Van Arsdell, Wahl, Westin, Will, Yin, Zhang, Zhao   +95 more
core   +4 more sources

Unwrapping the role of WRAP53β in DNA damage response [PDF]

, 2016
WRAP53β is a WD40 domain protein with multifaceted capabilities in several biological processes in different cellular compartments. This includes transportation of the Survival of motor neuron (SMN) complex, small Cajal body-specific (sca) RNAs and the ...
Rassoolzadeh, Hanif
core   +1 more source

The special Sm core structure of the U7 snRNP: far-reaching significance of a small nuclear ribonucleoprotein [PDF]

, 2018
.: The polypeptide composition of the U7 small nuclear ribonucleoprotein (snRNP) involved in histone messenger RNA (mRNA) 3′ end formation has recently been elucidated.
Pillai, R., Schümperli, D.
core  

Molecular bases of spinal muscular atrophy: the survival motor neuron gene [PDF]

, 2001
L'atròfia muscular espinal (AME) és una malaltia neuromuscular autosòmica recessiva caracteritzada per Ia degeneració i Ia pèrdua de Ies motoneurones de Ia banya anterior de Ia medul·la espinal.
Baiget Bastús, Montserrat, Tizzano, Eduardo   +1 more
core  

SMN Deficiency in SMA: Splicing Gone Awry [PDF]

Spinal muscular atrophy (SMA) is the most common motor neuron degenerative disease and is the principal genetic cause of infant mortality, affecting 1 in every 6000 newborns.
Levin, Stephanne
core   +1 more source

Chaperone dysfunction in motor neuron disease: new insights from studies of the SMN complex. [PDF]

Genetics
Matera AG.
europepmc   +1 more source

RNA-binding proteins in disease etiology: fragile X syndrome and spinal muscular atrophy. [PDF]

RNA
Dreyfuss G.
europepmc   +1 more source

Understanding GEMIN5 Interactions: From Structural and Functional Insights to Selective Translation. [PDF]

Wiley Interdiscip Rev RNA
Martinez-Salas E, Abellan S, Francisco-Velilla R.   +2 more
europepmc   +1 more source