Results 71 to 80 of about 634,892 (192)

Molecular medicine of microRNAs: structure, function and implications for diabetes [PDF]

, 2008
MicroRNAs (miRNAs) are a family of endogenous small noncoding RNA molecules, of 19–28 nucleotides in length. In humans, up to 3% of all genes are estimated to encode these evolutionarily conserved sequences.
Duncan, Erica Hennessy, Lorraine O'Driscoll, Offield, Schleicher, Zhou   +5 more
core   +1 more source

Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers [PDF]

, 2017
Small molecule splicing modifiers have been previously described that target the general splicing machinery and thus have low specificity for individual genes. Several potent molecules correcting the splicing deficit of the SMN2 (survival of motor neuron
Allain, F. H., Augustin, A., Banfai, B., Berntenis, N., Birrer, P., Campagne, S., Clery, A., Duran-Pacheco, G., Ebeling, M., Giroud, N., Golling, S., Heckel, T., Hsiu Liu, Y., Huber, S., Hug, M. N., Khawaja, S., Krainer, A. R., Lamerz, J., Luebbers, T., McCarthy, K. D., Meier, S., Meistermann, H., Metzger, F., Moursy, A., Paushkin, S., Ratni, H., Schmucki, R., Sivaramakrishnan, M., Tzouros, M.   +28 more
core   +1 more source

Accurate prediction of peptide binding sites on protein surfaces. [PDF]

PLoS Computational Biology, 2009
Many important protein-protein interactions are mediated by the binding of a short peptide stretch in one protein to a large globular segment in another.
Evangelia Petsalaki, Alexander Stark, Eduardo García-Urdiales, Robert B Russell, Robert B Russell   +4 more
doaj   +1 more source

Study of the protein-protein interactions between the SMN complex and the factors required for box C/D and H/ACA RNP assembly

, 2012
Les particules ribonucléoprotéiques (RNP) à boîtes C/D et H/ACA sont impliquées dans la maturation des UsnRNA et des précurseurs des ARNr. L'assemblage de ces RNP dans les cellules est un processus complexe faisant intervenir de nombreux facteurs cellulaires dont NUFIP, commun aux deux RNP, et NAF1, spécifique aux RNP à boîtes H/ACA.
Alexandra Huttin
openalex   +3 more sources

Enhanced expression of the central survival of motor neuron (SMN) protein during the pathogenesis of osteoarthritis [PDF]

, 2015
The identification of new components implicated in the pathogenesis of osteoarthritis (OA) might improve our understanding of the disease process.
Cucchiarini, Magali, Madry, Henning, Terwilliger, Ernest F   +2 more
core   +1 more source

A motor function for the DEAD-box RNA helicase, Gemin3, in Drosophila.

PLoS Genetics, 2008
The survival motor neuron (SMN) protein, the determining factor for spinal muscular atrophy (SMA), is complexed with a group of proteins in human cells. Gemin3 is the only RNA helicase in the SMN complex.
Ruben J Cauchi, Kay E Davies, Ji-Long Liu   +2 more
doaj   +1 more source

Unwrapping the role of WRAP53β in DNA damage response [PDF]

, 2016
WRAP53β is a WD40 domain protein with multifaceted capabilities in several biological processes in different cellular compartments. This includes transportation of the Survival of motor neuron (SMN) complex, small Cajal body-specific (sca) RNAs and the ...
Rassoolzadeh, Hanif
core   +1 more source

The Distribution of Complement Proteins in Soft and Hard Coronas Impacts Macrophage Uptake of Nanoparticles

Advanced Healthcare Materials, EarlyView.
Protein corona plays a critical role in the biological behavior of nanoparticles. This study investigates the distribution of complement proteins in soft corona and their impact on the macrophage uptake of polymer nanoparticles. It underlines the significance of soft corona investigation for understanding in vivo performance of nanomedicines.
Ying Qiu, Tianchang He, Chunjie Miao, Xinyang Shi, Yuanyuan Niu, Volker Mailänder, Daniel Crespy, Katharina Landfester, Shuai Jiang   +8 more
wiley   +1 more source

Chaperoning the chaperones: Proteomic analysis of the SMN complex reveals conserved and etiologic connections to the proteostasis network

bioRxiv
Molecular chaperones and co-chaperones are highly conserved cellular components that perform variety of duties related to the proper three-dimensional folding of the proteome.
A. G. Matera, Rebecca E. Steiner, C. A. Mills, L. E. Herring, Eric L. Garcia, Dr. Greg Matera   +5 more
semanticscholar   +1 more source

Implication of the SMN complex in the biogenesis and steady state level of the Signal Recognition Particle

Nucleic Acids Research, 2012
Spinal muscular atrophy is a severe motor neuron disease caused by reduced levels of the ubiquitous Survival of MotoNeurons (SMN) protein. SMN is part of a complex that is essential for spliceosomal UsnRNP biogenesis. Signal recognition particle (SRP) is
Nathalie Piazzon, F. Schlotter, S. Lefebvre, Maxime Dodré, A. Méreau, J. Soret, A. Besse, M. Barkats, R. Bordonné, C. Branlant, S. Massenet   +10 more
semanticscholar   +1 more source