Results 1 to 10 of about 43,875 (295)

Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi

Nature, 2019
Xiaofeng Qi, Heng Liu, Bonne Thompson
exaly   +3 more sources

Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2009
Juyong Brian Kim, Masaki Kato, Philip A. Beachy   +2 more
exaly   +2 more sources

Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand

Nature Communications, 2017
Smoothened receptors (SMO) play a key role in the Hedgehog signalling pathway. Here the authors present the structure of a multi-domain human SMO with a rationally designed stabilizing ligand bound in the transmembrane domain of the receptor, and propose
Fei Zhao, Gye Won Han, Suwen Zhao
exaly   +2 more sources

Cortisol regulates neonatal lung development via Smoothened [PDF]

Respiratory Research
Background Neonatal respiratory distress syndrome (NRDS), one of the main causes of neonatal death, is clinically characterized by progressive dyspnea and cyanosis 1 to 2 h after birth.
Shanshan Lu, Yifei Chen, Jiawen Song, Liangliang Ren, Jun Du, Donglai Shen, Jiayin Peng, Yao Yin, Xia Li, Yuqing Wang, Yan Gao, Siman Han, Yichang Jia, Yun Zhao, Yizheng Wang   +14 more
doaj   +2 more sources

Hedgehog regulates smoothened activity by inducing a conformational switch [PDF]

Nature, 2007
Yun Zhao, Chao Tong, Jin Jiang
exaly   +2 more sources

A Phase I, Multicenter, Open-Label, First-in-Human, Dose-Escalation Study of the Oral Smoothened Inhibitor Sonidegib (LDE225) in Patients with Advanced Solid Tumors [PDF]

Clinical Cancer Research, 2014
Anne L Thomas, Reinhard Dummer
exaly   +2 more sources

Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

eLife, 2021
A long-standing mystery in vertebrate Hedgehog signaling is how Patched 1 (PTCH1), the receptor for Hedgehog ligands, inhibits the activity of Smoothened, the protein that transmits the signal across the membrane. We previously proposed (Kinnebrew et al.,
Maia Kinnebrew, Giovanni Luchetti, Ria Sircar, Sara Frigui, Lucrezia Vittoria Viti, Tomoki Naito, Francis Beckert, Yasunori Saheki, Christian Siebold, Arun Radhakrishnan, Rajat Rohatgi   +10 more
doaj   +1 more source

Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation

Open Biology, 2021
Smoothened is a key receptor of the hedgehog pathway, but the roles of Smoothened in cardiac development remain incompletely understood. In this study, we found that the conditional knockout of Smoothened from the mesoderm impaired the development of the
Chaohui Zhang, Yuxin Li, Jiaheng Cao, Beibei Yu, Kaiyue Zhang, Ke Li, Xinhui Xu, Zhikun Guo, Yinming Liang, Xiao Yang, Zhongzhou Yang, Yunfu Sun, Vesa Kaartinen, Keyue Ding, Jikui Wang   +14 more
doaj   +1 more source

Identification of a potent antagonist of smoothened in hedgehog signaling

Cell & Bioscience, 2021
Background Hedgehog signaling is essential to the regulation of embryonic development, tissue homeostasis, and stem cell self-renewal, making it a prime target for developing cancer therapeutics.
Junwan Fan, Haowen Li, Lun Kuang, Zichen Zhao, Wenyan He, Chen Liu, Yongjun Wang, Steven Y. Cheng, Wei Chen   +8 more
doaj   +1 more source

Identification of Novel Smoothened Ligands Using Structure-Based Docking. [PDF]

PLoS ONE, 2016
The seven transmembrane protein Smoothened is required for Hedgehog signaling during embryonic development and adult tissue homeostasis. Inappropriate activation of the Hedgehog signalling pathway leads to cancers such as basal cell carcinoma and ...
Celine Lacroix, Inbar Fish, Hayarpi Torosyan, Pranavan Parathaman, John J Irwin, Brian K Shoichet, Stephane Angers   +6 more
doaj   +1 more source