Results 101 to 110 of about 49,437 (364)

Smoothened determines β-arrestin–mediated removal of the G protein–coupled receptor Gpr161 from the primary cilium

Journal of Cell Biology, 2016
Pal et al. describe a two-step process determining removal of the cilia-localized GPCR, Gpr161, upon sonic hedgehog signaling. First, β-arrestins are recruited by the signaling-competent receptor in a smoothened-dependent manner.
Kasturi Pal, Sun-Hee Hwang, B. Somatilaka, H. Badgandi, P. Jackson, K. DeFea, Saikat Mukhopadhyay   +6 more
semanticscholar   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Activation of heterotrimeric G proteins by Smoothened [PDF]

Proceedings of the National Academy of Sciences, 2006
The mechanisms by which the activation of Smoothened (Smo), a protein essential to the actions of the Hedgehog family of secreted proteins, is translated into signals that converge on the Gli transcription factors are not fully understood.
Cherisse DiLizio, Berangere Saucy, Natalia A. Riobo, David R. Manning   +3 more
openaire   +3 more sources

Automatic segmentation of Phonocardiogram using the occurrence of the cardiac events

Informatics in Medicine Unlocked, 2017
Objective: This paper presents automatic method of segmentation of heart sound using the occurrence of the cardiac rhythmic events. Methods: Noisy heart sound is filtered using the 6th order Chebyshev type I low pass filter to remove the redundant noise.
M. Vishwanath Shervegar, Ganesh V. Bhat
doaj   +1 more source

The hedgehog receptor patched is involved in cholesterol transport. [PDF]

PLoS ONE, 2011
Sonic hedgehog (Shh) signaling plays a crucial role in growth and patterning during embryonic development, and also in stem cell maintenance and tissue regeneration in adults. Aberrant Shh pathway activation is involved in the development of many tumors,
Michel Bidet, Olivier Joubert, Benoit Lacombe, Marine Ciantar, Rony Nehmé, Patrick Mollat, Lionel Brétillon, Hélène Faure, Robert Bittman, Martial Ruat, Isabelle Mus-Veteau   +10 more
doaj   +1 more source

The Arbitrary Trajectory Quantization Method

, 2001
The arbitrary trajectory quantization method (ATQM) is a time dependent approach to quasiclassical quantization based on the approximate dual relationship that exists between the quantum energy spectra and classical periodic orbits.
D. Biswas, D. Biswas, D. Biswas, D. Biswas, Debabrata Biswas, E.B. Bogomolny, E.J. Heller, E.J. Heller, H. Primack, J.B. Keller, M.C. Gutzwiller, S. Tomsovic, Y. Shimizu   +12 more
core   +1 more source

In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors. [PDF]

, 2016
Aberrant Hedgehog (Hh)/glioma-associated oncogene (GLI) signaling has been implicated in cancer progression. Here, we analyzed GLI1, Sonic Hedgehog (Shh) and NF-κB expression in 51 breast cancer (ductal carcinoma) tissues using immunohistochemistry ...
Bei, R., Benvenuto, M, Bonanno, E, Cucchi, Danilo, DE SMAELE, Enrico, DI STEFANO, Enrica, Fantini, M, Frajese, Gv, Gulino, Alberto, Masuelli, Laura, Mattera, Rosanna, Modesti, A, Orlandi, A, Screpanti, Isabella   +13 more
core   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Smoothened as a new therapeutic target for human osteosarcoma [PDF]

Molecular Cancer, 2010
Abstract Background The Hedgehog signaling pathway functions as an organizer in embryonic development. Recent studies have demonstrated constitutive activation of Hedgehog pathway in various types of malignancies. However, it remains unclear how Hedgehog pathway is involved in the pathogenesis of osteosarcoma.
Setsuro Komiya, Masataka Hirotsu, Y Matsunoshita, Hiroko Nagao, Hui Gao, Takao Setoguchi, Hiromi Sasaki, Osamu Kunigou   +7 more
openaire   +4 more sources

Fluctuating initial condition and smoothening effect on elliptic and triangular flow

, 2012
In heavy ion collisions, event-by-event fluctuations in participating nucleon positions can lead to triangular flow. Generally, one uses Monte-Carlo Glauber model to obtain the participating nucleon positions.
Chaudhuri, A. K., Haque, Md. Rihan, Roy, Victor   +2 more
core   +1 more source