Results 11 to 20 of about 43,875 (295)

Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. [PDF]

, 2009
Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium upon binding of Hh ligands to their receptor, Patched ...
Chen, Miao-Hsueh, Chuang, Pao-Tien, Wilson, Christopher W   +2 more
core   +8 more sources

High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened

eLife, 2022
The oncogenic G-protein-coupled receptor (GPCR) Smoothened (SMO) is a key transducer of the hedgehog (HH) morphogen, which plays an essential role in the patterning of epithelial structures.
Marina Gonçalves Antunes, Matthieu Sanial, Vincent Contremoulins, Sandra Carvalho, Anne Plessis, Isabelle Becam   +5 more
doaj   +1 more source

Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary Cilia

Cells, 2023
ADP-ribosylation factor-like protein 13B (ARL13B), a regulatory GTPase and guanine exchange factor (GEF), enriches in primary cilia and promotes tumorigenesis in part by regulating Smoothened (SMO), GLI, and Sonic Hedgehog (SHH) signaling.
Ping Shi, Jia Tian, Julianne C. Mallinger, Dahao Ling, Loic P. Deleyrolle, Jeremy C. McIntyre, Tamara Caspary, Joshua J. Breunig, Matthew R. Sarkisian   +8 more
doaj   +1 more source

Sonic Hedgehog Signaling in Cerebellar Development and Cancer

Frontiers in Cell and Developmental Biology, 2022
The sonic hedgehog (SHH) pathway regulates the development of the central nervous system in vertebrates. Aberrant regulation of SHH signaling pathways often causes neurodevelopmental diseases and brain tumors.
Wanchen Wang, Ryo Shiraishi, Ryo Shiraishi, Daisuke Kawauchi   +3 more
doaj   +1 more source

Case Report: Prenatal Diagnosis of Postaxial Polydactyly With Bi-Allelic Variants in Smoothened (SMO)

Frontiers in Genetics, 2022
Postaxial polydactyly is a common congenital malformation which involves complex genetic factors. This retrospective study analyzed the cytogenetic and molecular results of a Chinese fetus diagnosed with postaxial polydactyly of all four limbs.
Lihong Fan, Pengzhen Jin, Yeqing Qian, Guosong Shen, Xueping Shen, Minyue Dong, Minyue Dong   +6 more
doaj   +1 more source

Connexin 43 and Sonic Hedgehog Pathway Interplay in Glioblastoma Cell Proliferation and Migration

Biology, 2021
Glioblastoma (GBM) represents the most common primary brain tumor within the adult population. Current therapeutic options are still limited by high rate of recurrences and signalling axes that promote GBM aggressiveness.
Filippo Torrisi, Cristiana Alberghina, Debora Lo Furno, Agata Zappalà, Samuel Valable, Giovanni Li Volti, Daniele Tibullo, Nunzio Vicario, Rosalba Parenti   +8 more
doaj   +1 more source

In silico drug repurposing: An antifungal drug, itraconazole, repurposed as an anticancer agent using molecular docking

MGM Journal of Medical Sciences, 2020
Introduction: In recent years, increased cancer incidences and death rates due to it, have turned cancer to be a major problem worldwide. Approximately more than 7 million people globally die from cancer.
Sanika Dhorje, Poonam Lavhate, Amrita Srivastav   +2 more
doaj   +1 more source

Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors

Cells, 2018
Hedgehog-GLI (HH) signaling was originally identified as a critical morphogenetic pathway in embryonic development. Since its discovery, a multitude of studies have reported that HH signaling also plays key roles in a variety of cancer types and in ...
Silvia Pietrobono, Barbara Stecca
doaj   +1 more source

Update on glasdegib in acute myeloid leukemia – broadening horizons of Hedgehog pathway inhibitors

Acta Pharmaceutica, 2022
Numerous new emerging therapies, including oral targeted chemotherapies, have recently entered the therapeutic arsenal against acute myeloid leukemia (AML). The significant shift toward the use of these novel therapeutics, administered either alone or in
Fersing Cyril, Mathias Fanny
doaj   +1 more source

Regulation of Smoothened Trafficking and Abundance in Hedgehog Signaling

Frontiers in Cell and Developmental Biology, 2022
The GPCR-family protein Smoothened (Smo) is essential for Hedgehog (Hh) signal transduction in both insects and vertebrates. The regulation of subcellular localization and abundance of Smo is a critical step in Hh signaling.
Jianhang Jia, Jin Jiang
doaj   +1 more source