Results 11 to 20 of about 49,437 (364)

Mechanisms of Smoothened Regulation in Hedgehog Signaling [PDF]

Cells, 2021
The seven-transmembrane protein, Smoothened (SMO), has shown to be critical for the hedgehog (HH) signal transduction on the cell membrane (and the cilium in vertebrates).
Jie Zhang, Zulong Liu, Jianhang Jia
doaj   +5 more sources

Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors [PDF]

Cells, 2018
Hedgehog-GLI (HH) signaling was originally identified as a critical morphogenetic pathway in embryonic development. Since its discovery, a multitude of studies have reported that HH signaling also plays key roles in a variety of cancer types and in ...
Silvia Pietrobono, Barbara Stecca
doaj   +5 more sources

The Role of Smoothened in Cancer [PDF]

International Journal of Molecular Sciences, 2020
Smoothened (SMO) belongs to the Hedgehog (HH) signaling pathway, which regulates cell growth, migration, invasion and stem cells in cancer. The HH signaling pathway includes both canonical and noncanonical pathways.
K. Jeng, I. Sheen, C. Leu, Ping-Hui Tseng, Chiung-Fang Chang   +4 more
semanticscholar   +4 more sources

Activation mechanism of the human Smoothened receptor

Biophysical Journal, 2023
Smoothened (SMO) is a membrane protein of the Class F subfamily of G-Protein Coupled Receptors (GPCRs) and maintains homeostasis of cellular differentiation.
Prateek D. Bansal, Soumajit Dutta, D. Shukla   +2 more
semanticscholar   +3 more sources

Cilia-Associated Oxysterols Activate Smoothened. [PDF]

Molecular Cell, 2018
Primary cilia are required for Smoothened to transduce vertebrate Hedgehog signals, but how Smoothened accumulates in cilia and is activated is incompletely understood. Here, we identify cilia-associated oxysterols that promote Smoothened accumulation in cilia and activate the Hedgehog pathway.
D. Raleigh, Navdar Sever, P. Choksi, M. A. Sigg, Kelly M. Hines, Bonne M. Thompson, D. Elnatan, P. Jaishankar, P. Bisignano, F. Garcia-Gonzalo, A. Krup, M. Eberl, E. Byrne, C. Siebold, S. Y. Wong, A. Renslo, M. Grabe, J. McDonald, Libin Xu, P. Beachy, Jeremy F. Reiter   +20 more
semanticscholar   +9 more sources

Systemic Pharmacological Smoothened Inhibition Reduces Lung T-Cell Infiltration and Ameliorates Th2 Inflammation in a Mouse Model of Allergic Airway Disease

Frontiers in Immunology, 2021
Allergic asthma is a common inflammatory airway disease in which Th2 immune response and inflammation are thought to be triggered by inhalation of environmental allergens. Many studies using mouse models and human tissues and genome-wide association have
Diana C. Yánez, Diana C. Yánez, Eleftheria Papaioannou, Mira M. Chawda, Jasmine Rowell, Susan Ross, Ching-In Lau, Tessa Crompton   +7 more
doaj   +2 more sources

Disc measurement and nucleus calibration in a smoothened lumbar model increases the accuracy and efficiency of in-silico study

Journal of Orthopaedic Surgery and Research, 2021
Backgrounds Finite element analysis (FEA) is an important tool during the spinal biomechanical study. Irregular surfaces in FEA models directly reconstructed based on imaging data may increase the computational burden and decrease the computational ...
Jingchi Li, Chen Xu, Xiaoyu Zhang, Zhipeng Xi, Shenglu Sun, Ke Zhang, Xiaoyang Fang, Lin Xie, Yang Liu, Yueming Song   +9 more
doaj   +2 more sources

Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity. [PDF]

PLoS ONE, 2014
A requisite step for canonical Hedgehog (Hh) pathway activation by Sonic Hedgehog (Shh) ligand is accumulation of Smoothened (Smo) to the primary cilium (PC).
Marisa O Peluso, Veronica T Campbell, Joseph A Harari, Thomas T Tibbitts, Jennifer L Proctor, Nigel Whitebread, James M Conley, Kerry F White, Jeffery L Kutok, Margaret A Read, Karen McGovern, Kerrie L Faia   +11 more
doaj   +5 more sources

The Secret Life of Smoothened [PDF]

Developmental Cell, 2003
AbstractThe membrane protein Smoothened is the signal-generating component of the Hedgehog pathway. How Smoothened transmits the signal to downstream effectors in the cytoplasm has been a long-standing mystery. Now, with recent reports demonstrating a direct interaction between Smoothened and Costal-2, we appear to be significantly closer to solving ...
R Collins, Stephen M. Cohen
openalex   +4 more sources

Nonclassical Smoothening of Nanoscale Surface Corrugations [PDF]

Physical Review Letters, 2000
We report the first experimental observation of nonclassical morphological equilibration of a corrugated crystalline surface. Periodic rippled structures with wavelengths of 290-550 nm were made on Si(001) by sputter rippling and then annealed at 650-750 degrees C. In contrast to the classical exponential decay with time, the ripple amplitude Alambda(t)
Jonah Erlebacher, Michael J. Aziz, Eric Chason, Michael B. Sinclair, Jerrold A. Floro   +4 more
openalex   +4 more sources