Results 21 to 30 of about 49,437 (364)
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened [PDF]
Genes & Development, 2002 The steroidal alkaloid cyclopamine has both teratogenic and antitumor activities arising from its ability to specifically block cellular responses to vertebrate Hedgehog signaling.
James Chen +3 more
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Hedgehog Signaling: A Smoothened Conformational Switch [PDF]
Current Biology, 2008 An intracellular conformational switch in the serpentine transmembrane protein Smoothened appears to underlie Hedgehog pathway activation. The switch is gated by electrostatic interactions that are regulated by multiple phosphorylations, potentially endowing a dose-dependent response.
Daniel Kalderon
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Smoothening the Controversial Role of Hedgehog in Hematopoiesis [PDF]
Cell Stem Cell, 2009 The role of multiple developmental signaling pathways in the regulation of hematopoiesis has been controversial. In this issue of Cell Stem Cell, two separate reports (Hofmann et al., 2009; Gao et al., 2009) examine whether the Hedgehog signaling pathway modulates normal adult hematopoietic stem cells and blood formation.
Akil Merchant, William Matsui
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Nature Communications, 2017 Smoothened receptors (SMO) play a key role in the Hedgehog signalling pathway. Here the authors present the structure of a multi-domain human SMO with a rationally designed stabilizing ligand bound in the transmembrane domain of the receptor, and propose
Xianjun Zhang +20 more
doaj +2 more sources
Science Advances, 2022 Smoothened (SMO) transduces the Hedgehog (Hh) signal across the plasma membrane in response to accessible cholesterol. Cholesterol binds SMO at two sites: one in the extracellular cysteine-rich domain (CRD) and a second in the transmembrane domain (TMD).
M. Kinnebrew +14 more
semanticscholar +1 more source
Grking the Smoothened signal [PDF]
Science Signaling, 2018 The essential Hedgehog signaling component GRK2 functions at the level of and downstream of Smoothened in both flies and vertebrates (Li et al . and Pusapati et al ., in 6 February 2018 issue).
Hayley J. Sharpe, Frederic J. de Sauvage
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Smoothening out the patches [PDF]
Science, 2018 New roles are discovered for cholesterol transport in a key developmental signaling ...
Anselm Sommer, Mark A. Lemmon
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Smoothened Complete Electrode Model [PDF]
SIAM Journal on Applied Mathematics, 2017 This work reformulates the complete electrode model of electrical impedance tomography in order to enable more efficient numerical solution. The model traditionally assumes constant contact conductances on all electrodes, which leads to a discontinuous Robin boundary condition since the gaps between the electrodes can be described by vanishing ...
Mustonen, Lauri, Hyvönen, Nuutti
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The Role of Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis
Biomedicines, 2021 The Hedgehog (Hh)-glioma-associated oncogene homolog (GLI) signaling pathway is highly conserved among mammals, with crucial roles in regulating embryonic development as well as in cancer initiation and progression.
J. Chai +6 more
semanticscholar +1 more source
Journal of Clinical Investigation, 2021 Medulloblastoma is an aggressive pediatric brain tumor that can be driven by misactivation of the Hedgehog (HH) pathway. CDK6 is a critical effector of oncogenic Hedgehog signaling, but attempts to target the Hedgehog pathway in medulloblastoma have been
Vikas Daggubati +10 more
semanticscholar +1 more source