Results 11 to 20 of about 3,616 (129)

Hemoperfusion as Adjunctive Therapy in Severe Snake Envenomation Refractory to Antivenom: A Case Series. [PDF]

Clin Case Rep
ABSTRACT Snake envenomation remains a significant cause of morbidity worldwide, with antivenom serving as the cornerstone of treatment. This case series describes outcomes of three male patients (ages 34–63 years) with severe envenomation who demonstrated progressive local swelling and coagulopathy despite receiving at least 15 vials of antivenom.
Hosseini SM, Shadnia S, Mostafazadeh B, Rahimi M, Zandiyeh F, Nezhad AR, Evini PET.   +6 more
europepmc   +2 more sources

Immunological Cross-Reactivity and Neutralizing Efficacy of Antivenom Against Five Medically Important Iranian Viper Venoms. [PDF]

Vet Med Sci
Investigating Iranian viper venoms reveals compositional and antigenic diversity impacting antivenom efficacy. The study highlights the need to incorporate both broadly cross‐reactive and specifically under‐represented venoms into immunization mixtures to optimize paraspecific protection strategies.
Khamehchian S, Tahoori F, Rabie H, Nasrabadi NN, Tebianian M.   +4 more
europepmc   +2 more sources

Systemic impact of intramuscular snake envenomation and intravenous immunoglobulin-based antivenom treatment on murine plasma proteome and peptidome. [PDF]

Protein Sci
Abstract Snake envenomation remains a critical global public health challenge. In Brazil, the genus Bothrops is responsible for most accidents, typically resulting in coagulopathy, hemorrhage, and renal failure. Despite its clinical prevalence, the molecular mechanisms driving plasma protein disturbances remain poorly understood.
de Barros BCSC, Chaves AFA, Morone MSLC, Sachetto ATA, Santoro ML, Schilling O, Serrano SMT.   +6 more
europepmc   +2 more sources

Snakebite and local envenomation by Boiruna maculata treated without antivenom

Acute Medicine & Surgery, 2021
Background When snake breeders are bitten by rare snakes, deciding whether to administer snake antivenom can be challenging. Case Presentation A 50‐year‐old man was bitten on the right finger by Boiruna maculata.
Shou Terashige, Takashi Nishiyama, Shigeto Takeshima, Kosuke Hatanaka, Takao Sugiura, Ruka Sasa, Daishi Higashiyama, Fumika Tanaka   +7 more
doaj   +1 more source

Antivenom availability, delays and use in Australia

Toxicon: X, 2023
Antivenom is the main treatment for snake envenoming and there are ongoing concerns about availability in resource poor regions of the world. However, effective antivenom treatment for snake envenoming requires more than improved availability of safe and
Geoffrey K. Isbister
doaj   +1 more source

Detection of Snake Venom in Post-Antivenom Samples by Dissociation Treatment Followed by Enzyme Immunoassay

Toxins, 2016
Venom detection is crucial for confirmation of envenomation and snake type in snake-bite patients. Enzyme immunoassay (EIA) is used to detect venom, but antivenom in samples prevents venom detection.
Kalana P. Maduwage, Margaret A. O’Leary, Anjana Silva, Geoffrey K. Isbister   +3 more
doaj   +1 more source

Allergic reactions to antivenom in a patient bitten twice by the same snake within a month: A rare case report and literature review

Chinese Journal of Traumatology, 2017
Antivenom is the most effective method currently available for the treatment of poisonous snake bite. Allergic reactions to antivenom have been reported in the past.
Fan-Jie Zeng, Cong Chen, Ming-Hua Liu
doaj   +1 more source

Population Pharmacokinetics of an Indian F(ab')2 Snake Antivenom in Patients with Russell's Viper (Daboia russelii) Bites. [PDF]

PLoS Neglected Tropical Diseases, 2015
There is limited information on antivenom pharmacokinetics. This study aimed to investigate the pharmacokinetics of an Indian snake antivenom in humans with Russell's viper bites.Patient data and serial blood samples were collected from patients with ...
Geoffrey K Isbister, Kalana Maduwage, Ana Saiao, Nicholas A Buckley, Shaluka F Jayamanne, Shahmy Seyed, Fahim Mohamed, Umesh Chathuranga, Alexandre Mendes, Chandana Abeysinghe, Harindra Karunathilake, Indika Gawarammana, David G Lalloo, H Janaka de Silva   +13 more
doaj   +1 more source

Mathematical Model of In-host Dynamics of Snakebite Envenoming

Journal of Nigerian Society of Physical Sciences, 2022
In this paper, we develop an in-host mathematical model of snakebite envenoming that includes tissue, red blood and platelet cells of humans as specific targets of different kinds of toxins in the snake venom.
S. A. Abdullahi, N. Hussaini, A. G. Habib   +2 more
doaj   +1 more source

Engineering Antivenom: Research Progress and Future Directions in Snakebite Envenoming Therapy. [PDF]

Ann N Y Acad Sci
Snakebite envenoming therapy is evolving from plasma‐derived antivenoms toward rationally engineered therapeutics. Advances in toxicovenomics, structural biology, antibody engineering, computational protein design, recombinant expression, small‐molecule inhibitors, and diagnostics are enabling toxin‐centric development of safer, more effective, and ...
Laustsen AH.
europepmc   +2 more sources