Inflammatory effects of snake venom metalloproteinases [PDF]
Memorias do Instituto Oswaldo Cruz, 2005 Metalloproteinases are abundant enzymes in crotaline and viperine snake venoms. They are relevant in the pathophysiology of envenomation, being responsible for local and systemic hemorrhage frequently observed in the victims.
Catarina de Fátima Pereira Teixeira +3 more
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Snake Venom Metalloproteinases (SVMPs): A structure-function update
Toxicon: X, 2020 Snake venom metalloproteinases (SVMPs) represent a diverse group of multi-domain proteins with several biological activities such as the ability to induce hemorrhage, proteolytic degradation of fibrinogen and fibrin, induction of apoptosis and inhibition
Olamide Tosin Olaoba +3 more
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Snake Venom Metalloproteinases and Their Peptide Inhibitors from Myanmar Russell’s Viper Venom [PDF]
Toxins, 2016 Russell’s viper bites are potentially fatal from severe bleeding, renal failure and capillary leakage. Snake venom metalloproteinases (SVMPs) are attributed to these effects.
Khin Than Yee +4 more
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Venomics of the Arabian saw-scaled viper (Echis coloratus) through transcriptome-guided proteomics and in vitro functional profiling. [PDF]
PLoS Neglected Tropical DiseasesThe Arabian saw-scaled viper (Echis coloratus) is among the snakes of highest medical relevance in the Middle East and North Africa. However, to date, its venom has been investigated in a very limited number of studies, and much remains unknown regarding
Ignazio Avella +10 more
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Structures and Functions of Snake Venom Metalloproteinases (SVMP) from Protobothrops venom Collected in Japan [PDF]
Molecules, 2017 Snake venom metalloproteinases (SVMP) are widely distributed among the venoms of Crotalinae and Viperidae, and are organized into three classes (P-I, P-II and P-III) according to their size and domain structure.
Etsuko Oyama, Hidenobu Takahashi
doaj +3 more sources
Dabsylated Bradykinin Is Cleaved by Snake Venom Proteases from Echis ocellatus
BiomedicinesThe vasoactive peptide bradykinin (BK) is an important member of the renin–angiotensin system. Its discovery is tightly interwoven with snake venom research, because it was first detected in plasma following the addition of viper venom.
Julius Abiola +4 more
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Snake Venom Metalloproteinases from Puff Adder and Saw-Scaled Viper Venoms Cause Cytotoxic Effects in Human Keratinocytes. [PDF]
Toxins (Basel)Snakebite envenoming is a neglected tropical disease that causes substantial mortality and morbidity globally. The puff adder (Bitis arietans) and saw-scaled viper (Echis romani) have cytotoxic venoms that cause permanent injury via dermonecrosis around ...
Bartlett KE +3 more
europepmc +2 more sources
Doxycycline-Mediated Inhibition of Snake Venom Phospholipase and Metalloproteinase.
Military MedicineINTRODUCTION Warfighters are exposed to life-threatening injuries daily and according to the Joint Trauma System Military Clinical Practice Guideline-Global Snake Envenomation Management snakebites are a concerning threat in all theaters of operation ...
Daniel K Arens +8 more
semanticscholar +3 more sources
Combination of Rhamnetin and RXP03 Mitigates Venom-Induced Toxicity in Murine Models: Preclinical Insights into Dual-Target Antivenom Therapy [PDF]
ToxinsSnakebite is a significant global public health challenge, and the limited application of antivenom has driven the exploration of novel therapies. Combination therapy using small-molecule drugs targeting phospholipases A2 (PLA2) and metalloproteinases ...
Jianqi Zhao +3 more
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Snake Venom Metalloproteinases [PDF]
Acta Medica Marisiensis, 2016 Abstract As more data are generated from proteome and transcriptome analysis revealing that metalloproteinases represent most of the Viperid and Colubrid venom components authors decided to describe in a short review a classification and some of the multiple activities of snake venom metalloproteinases.
Teresa Escalante +3 more
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