Results 61 to 70 of about 55,518 (304)

Guiding AlphaFold to predict how Munc13-1 opens Syntaxin-1. [PDF]

FEBS Open Bio
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Chattopadhyay M, Xu J, Rizo J.
europepmc   +2 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Intrinsic Disorder of the Neuronal SNARE Protein SNAP25a in its Pre-fusion Conformation [PDF]

, 2022
The neuronal Q-SNARE protein SNAP25a (isoform 2) forms part of the SNARE complex eliciting synaptic vesicle fusion during neuronal exocytosis. While the post-fusion cis-SNARE complex has been studied extensively, little is known about the pre-fusion ...
Sonja, Sonja Pribicevic, Nils-Alexander, Lakomek, Reinhard, Jahn, Lothar, Gremer, Tobias, Stief, Angel, Perez-Lara   +5 more
core   +2 more sources

Use of Snares to Live-Capture Beavers

Human-Wildlife Interactions, 2017
Wildlife managers, researchers, and nuisance-control operators often require a nonlethal means of capturing beavers (Castor canadensis). Historically, live-capture has relied on enclosure-type traps such as Bailey or Hancock traps.
Lance B. McNew Jr., Clayton K. Nielsen, Craig K. Bloomquist   +2 more
doaj   +1 more source

Endosomal and Phagosomal SNAREs [PDF]

Physiological Reviews, 2018
The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein family is of vital importance for organelle communication. The complexing of cognate SNARE members present in both the donor and target organellar membranes drives the membrane fusion required for intracellular transport.
Ilse Dingjan, Peter T. A. Linders, Danielle R. J. Verboogen, Natalia H. Revelo, Martin ter Beest, Geert van den Bogaart   +5 more
openaire   +4 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Phosphoinositides and SNARE Chaperones Synergistically Assemble and Remodel SNARE Complexes for Membrane Fusion [PDF]

, 2009
Yeast vacuole fusion requires 4 SNAREs, 2 SNARE chaperone systems (Sec17p/Sec18p/ATP and the HOPS complex), and 2 phosphoinositides, phosphatidylinositol 3-phosphate [PI(3)P] and phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2].
Mima, Joji, Wickner, William
core   +1 more source

Percutaneous Salvage of an Impella Pretzel

JACC: Case Reports, 2019
This report describes a case in which bedside manipulation of an Impella CP led to device entanglement in the aorta. Using a snare and counter-traction, we were able to untangle and re-deliver it into the left ventricle to restore normal device support. (
Moses Mathur, MD, MSc, Adam Mohmand-Borkowski, MD, Mariko Harper, MD, Gordon Kritzer, MD   +3 more
doaj   +1 more source