Results 61 to 70 of about 145,612 (349)

γ-synuclein is a novel player in the control of body lipid metabolism [PDF]

, 2013
Peer reviewedPublisher ...
Buchman, Vladimir L, Millership, Steven, Ninkina, Natalia, Rochford, Justin J   +3 more
core   +1 more source

A comparison of the resection rate for cold and hot snare polypectomy for 4–9 mm colorectal polyps: a multicentre randomised controlled trial (CRESCENT study)

Gut, 2017
Objective To investigate the success rate of cold snare polypectomy (CSP) for complete resection of 4–9 mm colorectal adenomatous polyps compared with that of hot snare polypectomy (HSP). Design A prospective, multicentre, randomised controlled, parallel,
T. Kawamura, Y. Takeuchi, S. Asai, I. Yokota, E. Akamine, Minoru Kato, Takuji Akamatsu, Kazuhiro Tada, Y. Komeda, Mineo Iwatate, K. Kawakami, Michiko Nishikawa, D. Watanabe, A. Yamauchi, N. Fukata, M. Shimatani, M. Ooi, K. Fujita, Y. Sano, H. Kashida, Satoru Hirose, H. Iwagami, N. Uedo, S. Teramukai, Kiyohito Tanaka   +24 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis

eLife, 2015
Synaptic-soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) proteins couple their stage-wise folding/assembly to rapid exocytosis of neurotransmitters in a Munc18-1-dependent manner.
Lu Ma, Aleksander A Rebane, Guangcan Yang, Zhiqun Xi, Yuhao Kang, Ying Gao, Yongli Zhang   +6 more
doaj   +1 more source

Cleaved intracellular SNARE peptides are implicated in a novel cytotoxicity mechanism of botulinum serotype C [PDF]

, 2013
Recent advances in intracellular protein delivery have enabled more in-depth analyses of cellular functions. A specialized family of SNARE proteases, known as Botulinum Neurotoxins, blocks neurotransmitter exocytosis, which leads to systemic toxicity ...
Arsenault, Jason, Cuijpers, Sabine A. G., Davletov, Bazbek, Ferrari, Enrico, Niranjan, Dhevahi, O'Brien, John A.   +5 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

The Sec1/Munc18 protein Vps45 holds the Qa-SNARE Tlg2 in an open conformation

eLife, 2020
Fusion of intracellular trafficking vesicles is mediated by the assembly of SNARE proteins into membrane-bridging complexes. SNARE-mediated membrane fusion requires Sec1/Munc18-family (SM) proteins, SNARE chaperones that can function as templates to ...
Travis J Eisemann, Frederick Allen, Kelly Lau, Gregory R Shimamura, Philip D Jeffrey, Frederick M Hughson   +5 more
doaj   +1 more source

SNARE protein mimicry by an intracellular bacterium. [PDF]

PLoS Pathogens, 2008
Many intracellular pathogens rely on host cell membrane compartments for their survival. The strategies they have developed to subvert intracellular trafficking are often unknown, and SNARE proteins, which are essential for membrane fusion, are possible ...
Cédric Delevoye, Michael Nilges, Pierre Dehoux, Fabienne Paumet, Stéphanie Perrinet, Alice Dautry-Varsat, Agathe Subtil   +6 more
doaj   +1 more source

Numerical Experiments with Coupled Membranes and the Snare Mechanism [PDF]

, 2010
National audienceThe snare drum is one of the more complex musical instruments from a modeling and synthesis perspective---it includes elements modeled as 0D (the drum stick), 1D (the snares), 2D (a pair of membranes) and 3D (the cavity and perhaps the ...
Bilbao, Stefan
core   +1 more source