Results 51 to 60 of about 41,580 (266)

Glass Half Empty or Half Full: Single-Session Endoscopic Removal of Multiple Glass Vials in the Upper Gastrointestinal Tract Using a Novel Approach

Journal of Digestive Endoscopy
Foreign body ingestion is a commonly encountered problem clinically with management targeted at early radiological imaging to identify high-risk features that can increase the risk of perforation. We present a 23-year-old patient with no known medical or
Raghav Bassi, Gabriel S. Silva, Tony S. Brar, Yaseen Perbtani   +3 more
doaj   +1 more source

Percutaneous Salvage of an Impella Pretzel

JACC: Case Reports, 2019
This report describes a case in which bedside manipulation of an Impella CP led to device entanglement in the aorta. Using a snare and counter-traction, we were able to untangle and re-deliver it into the left ventricle to restore normal device support. (
Moses Mathur, MD, MSc, Adam Mohmand-Borkowski, MD, Mariko Harper, MD, Gordon Kritzer, MD   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A–F Employing Taguchi Design-of-Experiments

Toxins, 2019
The detection of catalytically active botulinum neurotoxins (BoNTs) can be achieved by monitoring the enzymatic cleavage of soluble NSF (N-ethylmaleimide-sensitive-factor) attachment protein receptor (SNARE) proteins by the toxins’ light chains (LC)
Laura von Berg, Daniel Stern, Jasmin Weisemann, Andreas Rummel, Martin Bernhard Dorner, Brigitte Gertrud Dorner   +5 more
doaj   +1 more source

Identification of SNARE Proteins Through a Novel Hybrid Model

IEEE Access, 2020
SNARE proteins are a large family of membrane fusion proteins. As a lot of human diseases are related to the SNARE proteins, they have attracted people to study them.
Guilin Li
doaj   +1 more source

The influence of cell membrane and SNAP25 linker loop on the dynamics and unzipping of SNARE complex. [PDF]

PLoS ONE, 2017
The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex is composed of three neuronal proteins VAMP2, Syntaxin and SNAP25, which plays a core role during the process of membrane fusion.
Yi Shi, Yong Zhang, Jizhong Lou
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A snare retrieval experience of coil migration in a large coronary artery fistula

International Journal of the Cardiovascular Academy, 2018
A 45-year-old female patient was referred due to the abnormal myocardial perfusion scintigraphy showing ischemia in the inferior and lateral wall. Coronary arteries were normal, and a large fistula was detected from the proximal portion of the circumflex
Mithat Selvi, Hasan Gungor, Sevil Gulasti   +2 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source