Results 81 to 90 of about 150,506 (397)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Identification of SNARE Proteins Through a Novel Hybrid Model

IEEE Access, 2020
SNARE proteins are a large family of membrane fusion proteins. As a lot of human diseases are related to the SNARE proteins, they have attracted people to study them.
Guilin Li
doaj   +1 more source

The influence of cell membrane and SNAP25 linker loop on the dynamics and unzipping of SNARE complex. [PDF]

PLoS ONE, 2017
The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex is composed of three neuronal proteins VAMP2, Syntaxin and SNAP25, which plays a core role during the process of membrane fusion.
Yi Shi, Yong Zhang, Jizhong Lou
doaj   +1 more source

Scalable dual-omics profiling with single-nucleus chromatin accessibility and mRNA expression sequencing 2 (SNARE-seq2) [PDF]

, 2021
Nongluk Plongthongkum, Dinh Diep, Song Chen, Blue B. Lake, Kun Zhang   +4 more
openalex   +1 more source

Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function [PDF]

, 2018
Loss of functional β-cell mass is an early feature of type 1 diabetes. To release insulin, β-cells require soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes, as well as SNARE complex regulatory proteins like double ...
Ahn, Miwon, Aslamy, Arianne, Moin, Abu Saleh Md, Oh, Eunjin, Olson, Erika M., Salunkhe, Vishal A., Thurmond, Debbie C., Tunduguru, Ragadeepthi, Veluthakal, Rajakrishnan, Zhang, Jing   +9 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A–F Employing Taguchi Design-of-Experiments

Toxins, 2019
The detection of catalytically active botulinum neurotoxins (BoNTs) can be achieved by monitoring the enzymatic cleavage of soluble NSF (N-ethylmaleimide-sensitive-factor) attachment protein receptor (SNARE) proteins by the toxins’ light chains (LC)
Laura von Berg, Daniel Stern, Jasmin Weisemann, Andreas Rummel, Martin Bernhard Dorner, Brigitte Gertrud Dorner   +5 more
doaj   +1 more source

SNARE-CNN: a 2D convolutional neural network architecture to identify SNARE proteins from high-throughput sequencing data

PeerJ Computer Science, 2019
Deep learning has been increasingly and widely used to solve numerous problems in various fields with state-of-the-art performance. It can also be applied in bioinformatics to reduce the requirement for feature extraction and reach high performance. This
N. Le, Van-Nui Nguyen
semanticscholar   +1 more source

Using Beatboxing for Creative Rehabilitation After Laryngectomy:Experiences From a Public Engagement Project [PDF]

, 2020
Laryngectomy is the surgical removal of the larynx (voice box), usually performed in patients with advanced stages of throat cancer. The psychosocial impact of losing the voice is significant, affecting a person’s professional and social life in a ...
Abo-El-Enein, Bohnenkamp, Bussian, Cohen, Danker, de Torcy, Dejonckere, Dooks, Elmiyeh, Gatta, Guo, Gupta, Gupta, Himonides, Jongmans, Kaye, Kent, Keszte, Kitamura, Kleber, Mürbe, O’Grady, Perry, Proctor, Smith, Splinter, Staffieri, Stevens, Stowell, Stowell, Sundberg, van As, Welch, Westra, Wright   +34 more
core   +3 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source