Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion [PDF]
, 2002 Characterization of mammalian NSF (G274E) and Drosophila NSF (comatose) mutants revealed an evolutionarily conserved NSF activity distinct from ATPase-dependent SNARE disassembly that was essential for Golgi membrane fusion.
Yuval Sagiv +15 more
core +1 more source
EpsinR Is an Adaptor for the SNARE Protein Vti1b [PDF]
Molecular Biology of the Cell, 2004 EpsinR is a clathrin-coated vesicle (CCV)-associated protein that binds to vti1b, suggesting that it may be a vti1b-selective adaptor. Depletion of epsinR to undetectable levels in HeLa cells using siRNA causes vti1b to redistribute from the perinuclear region to the cell periphery, but vti1a also redistributes in epsinR-depleted cells, and both vti ...
Hirst, J +4 more
openaire +5 more sources
Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function [PDF]
, 2011 Cholesterol regulates plasma membrane (PM) association and functioning of syntaxin-4 and soluble N-ethylmaleimide-sensitive fusion protein 23 (SNAP23) in the secretory pathway.
Enrich Bastús, Carles +25 more
core +1 more source
The mesoscale organization of syntaxin 1A and SNAP25 is determined by SNARE–SNARE interactions
eLife, 2021 SNARE proteins have been described as the effectors of fusion events in the secretory pathway more than two decades ago. The strong interactions between SNARE domains are clearly important in membrane fusion, but it is unclear whether they are involved ...
Jasmin Mertins +5 more
doaj +1 more source
The Multifaceted Role of SNARE Proteins in Membrane Fusion. [PDF]
Front Physiol, 2017 Membrane fusion is a key process in all living organisms that contributes to a variety of biological processes including viral infection, cell fertilization, as well as intracellular transport, and neurotransmitter release.
Han J, Pluhackova K, Böckmann RA.
europepmc +3 more sources
Regional and developmental brain expression patterns of SNAP25 splice variants [PDF]
, 2011 SNAP25 is an essential SNARE protein for regulated exocytosis in neuronal cells. Differential splicing of the SNAP25 gene results in the expression of two transcripts, SNAP25a and SNAP25b.
Chamberlain, Luke H. +7 more
core +1 more source
A Pearson Based Feature Compressing Model for SNARE Protein Classification
IEEE Access, 2020 SNARE proteins are a group of proteins that drive the biological fusion of two membranes. It is important to identify them accurately, because malfunction of the SNARE proteins can lead to a lot of diseases.
Guilin Li
doaj +1 more source
Postsynaptic SNARE Proteins: Role in Synaptic Transmission and Plasticity. [PDF]
Neuroscience, 2019 This article is part of a Special Issue entitled: SNARE proteins: a long journey of science in brain physiology and pathology: from molecular.Soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) proteins mediate membrane fusion ...
Madrigal MP +3 more
europepmc +3 more sources
A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells [PDF]
, 2008 Mannose 6-phosphate receptors (MPRs) are transported from endosomes to the Golgi after delivering lysosomal enzymes to the endocytic pathway. This process requires Rab9 guanosine triphosphatase (GTPase) and the putative tether GCC185.
Espinosa, Eric +5 more
core +1 more source
An activated Q‐SNARE/SM protein complex as a possible intermediate in SNARE assembly [PDF]
The EMBO Journal, 2017 Assembly of the SNARE proteins syntaxin1, SNAP25, and synaptobrevin into a SNARE complex is essential for exocytosis in neurons. For efficient assembly, SNAREs interact with additional proteins but neither the nature of the intermediates nor the sequence of protein assembly is known.
Shrutee Jakhanwal +3 more
openaire +4 more sources