γ-synuclein is a novel player in the control of body lipid metabolism [PDF]
, 2013 Peer reviewedPublisher ...
Buchman, Vladimir L +3 more
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A Pearson Based Feature Compressing Model for SNARE Protein Classification
IEEE Access, 2020 SNARE proteins are a group of proteins that drive the biological fusion of two membranes. It is important to identify them accurately, because malfunction of the SNARE proteins can lead to a lot of diseases.
Guilin Li
doaj +1 more source
SNARE zippering requires activation by SNARE-like peptides in Sec1/Munc18 proteins [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance Soluble N -ethylmaleimide-sensitive factor attachment protein receptor(SNARE) proteins drive membrane fusion by zippering into coiled-coil bundles between membrane bilayers. In this work, we showed that certain layers in the SNARE bundle are dispensable for SNARE-mediated membrane fusion ...
Haijia Yu +6 more
openaire +2 more sources
The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth. [PDF]
, 2010 Previous studies have implicated DTNBP1 as a schizophrenia susceptibility gene and its encoded protein, dysbindin, as a potential regulator of synaptic vesicle physiology.
Chan, LN +9 more
core +2 more sources
Reconciling the regulatory role of Munc18 proteins in SNARE-complex assembly
IUCrJ, 2014 Membrane fusion is essential for human health, playing a vital role in processes as diverse as neurotransmission and blood glucose control. Two protein families are key: (1) the Sec1p/Munc18 (SM) and (2) the soluble N-ethylmaleimide-sensitive attachment ...
Asma Rehman +5 more
doaj +1 more source
Molecular Dynamics Simulations of the Proteins Regulating Synaptic Vesicle Fusion
Membranes, 2023 Neuronal transmitters are packaged in synaptic vesicles (SVs) and released by the fusion of SVs with the presynaptic membrane (PM). An inflow of Ca2+ into the nerve terminal triggers fusion, and the SV-associated protein Synaptotagmin 1 (Syt1) serves as ...
Maria Bykhovskaia
doaj +1 more source
The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons. [PDF]
, 2016 Cell polarity and precise subcellular protein localization are pivotal to neuronal function. The SNARE machinery underlies intracellular membrane fusion events, but its role in neuronal polarity and selective protein targeting remain unclear.
Albertolle, Mary E +7 more
core +1 more source
eLife, 2017 Intracellular membrane fusion mediates diverse processes including cell growth, division and communication. Fusion involves complex formation between SNARE proteins anchored to adjacent membranes.
Matthias Karnahl +4 more
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ATP-independent Control of Vac8 Palmitoylation by a SNARE Subcomplex on Yeast Vacuoles [PDF]
, 2005 Yeast vacuole fusion requires palmitoylated Vac8. We previously showed that Vac8 acylation occurs early in the fusion reaction, is blocked by antibodies against Sec18 (yeast N-ethylmaleimide-sensitive fusion protein (NSF)), and is mediated by the R-SNARE
Cristodero, Marina +5 more
core +1 more source
Role of SNAREs in Neurodegenerative Diseases
Cells, 2021 Neurodegenerative diseases are pathologies of the central and peripheral nervous systems characterized by loss of brain functions and problems in movement which occur due to the slow and progressive degeneration of cellular elements.
Azzurra Margiotta
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