Results 11 to 20 of about 26,045 (209)
SNARE protein mimicry by an intracellular bacterium. [PDF]
PLoS Pathogens, 2008 Many intracellular pathogens rely on host cell membrane compartments for their survival. The strategies they have developed to subvert intracellular trafficking are often unknown, and SNARE proteins, which are essential for membrane fusion, are possible ...
Cédric Delevoye +6 more
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The Sec1/Munc18 protein Vps45 holds the Qa-SNARE Tlg2 in an open conformation
eLife, 2020 Fusion of intracellular trafficking vesicles is mediated by the assembly of SNARE proteins into membrane-bridging complexes. SNARE-mediated membrane fusion requires Sec1/Munc18-family (SM) proteins, SNARE chaperones that can function as templates to ...
Travis J Eisemann +5 more
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An electrostatically preferred lateral orientation of SNARE complex suggests novel mechanisms for driving membrane fusion. [PDF]
PLoS ONE, 2010 Biological membrane fusion is a basic cellular process catalyzed by SNARE proteins and additional auxiliary factors. Yet, the critical mechanistic details of SNARE-catalyzed membrane fusion are poorly understood, especially during rapid synaptic ...
Ting Guo, Lin-Chen Gong, Sen-Fang Sui
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Intracellular bacteria encode inhibitory SNARE-like proteins. [PDF]
PLoS ONE, 2009 Pathogens use diverse molecular machines to penetrate host cells and manipulate intracellular vesicular trafficking. Viruses employ glycoproteins, functionally and structurally similar to the SNARE proteins, to induce eukaryotic membrane fusion ...
Fabienne Paumet +7 more
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Epileptic Phenotypes Associated With SNAREs and Related Synaptic Vesicle Exocytosis Machinery
Frontiers in Neurology, 2022 SNAREs (soluble N-ethylmaleimide sensitive factor attachment protein receptor) are an heterogeneous family of proteins that, together with their key regulators, are implicated in synaptic vesicle exocytosis and synaptic transmission. SNAREs represent the
Elisa Cali +3 more
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A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes
Cell & Bioscience, 2023 Background People of Sub-Saharan African ancestry are at higher risk of developing chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (APOL1) gene risk alleles (RA) G1 and G2. The underlying mechanisms by which the APOL1-RA precipitate CKD
Jin-Gu Lee +6 more
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Cell Reports, 2013 Rapid endocytosis, which takes only a few seconds, is widely observed in secretory cells. Although it is more efficient in recycling vesicles than in slow clathrin-mediated endocytosis, its underlying mechanism, thought to be clathrin independent, is ...
Jianhua Xu +7 more
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The mesoscale organization of syntaxin 1A and SNAP25 is determined by SNARE–SNARE interactions
eLife, 2021 SNARE proteins have been described as the effectors of fusion events in the secretory pathway more than two decades ago. The strong interactions between SNARE domains are clearly important in membrane fusion, but it is unclear whether they are involved ...
Jasmin Mertins +5 more
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A Pearson Based Feature Compressing Model for SNARE Protein Classification
IEEE Access, 2020 SNARE proteins are a group of proteins that drive the biological fusion of two membranes. It is important to identify them accurately, because malfunction of the SNARE proteins can lead to a lot of diseases.
Guilin Li
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Reconciling the regulatory role of Munc18 proteins in SNARE-complex assembly
IUCrJ, 2014 Membrane fusion is essential for human health, playing a vital role in processes as diverse as neurotransmission and blood glucose control. Two protein families are key: (1) the Sec1p/Munc18 (SM) and (2) the soluble N-ethylmaleimide-sensitive attachment ...
Asma Rehman +5 more
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