New insights regarding SNARE proteins in autophagosome-lysosome fusion. [PDF]
Autophagy, 2021 Tian X, Teng J, Chen J.
europepmc +2 more sources
SNARE Modulators and SNARE Mimetic Peptides
Biomolecules, 2022 The soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptor (SNARE) proteins play a central role in most forms of intracellular membrane trafficking, a key process that allows for membrane and biocargo shuffling between ...
Mikhail Khvotchev, Mikhail Soloviev
doaj +1 more source
Identification of SNARE Proteins Through a Novel Hybrid Model
IEEE Access, 2020 SNARE proteins are a large family of membrane fusion proteins. As a lot of human diseases are related to the SNARE proteins, they have attracted people to study them.
Guilin Li
doaj +1 more source
Negative regulation of syntaxin4/SNAP-23/VAMP2-mediated membrane fusion by Munc18c in vitro. [PDF]
PLoS ONE, 2008 Translocation of the facilitative glucose transporter GLUT4 from an intracellular store to the plasma membrane is responsible for the increased rate of glucose transport into fat and muscle cells in response to insulin. This represents a specialised form
Fiona M Brandie +5 more
doaj +1 more source
SNARE Zippering Is Suppressed by a Conformational Constraint that Is Removed by v-SNARE Splitting
Cell Reports, 2021 Summary: Intracellular vesicle fusion is catalyzed by soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). Vesicle-anchored v-SNAREs pair with target membrane-associated t-SNAREs to form trans-SNARE complexes, releasing free ...
Yinghui Liu +5 more
doaj +1 more source
The Sec1/Munc18 protein Vps45 holds the Qa-SNARE Tlg2 in an open conformation
eLife, 2020 Fusion of intracellular trafficking vesicles is mediated by the assembly of SNARE proteins into membrane-bridging complexes. SNARE-mediated membrane fusion requires Sec1/Munc18-family (SM) proteins, SNARE chaperones that can function as templates to ...
Travis J Eisemann +5 more
doaj +1 more source
An electrostatically preferred lateral orientation of SNARE complex suggests novel mechanisms for driving membrane fusion. [PDF]
PLoS ONE, 2010 Biological membrane fusion is a basic cellular process catalyzed by SNARE proteins and additional auxiliary factors. Yet, the critical mechanistic details of SNARE-catalyzed membrane fusion are poorly understood, especially during rapid synaptic ...
Ting Guo, Lin-Chen Gong, Sen-Fang Sui
doaj +1 more source
SNARE proteins in membrane trafficking [PDF]
Traffic, 2017 SNAREsare the core machinery mediating membrane fusion. In this review, we provide an update on the recent progress onSNAREsregulating membrane fusion events, especially the more detailed fusion processes dissected by well‐developed biophysical methods and in vitro single molecule analysis approaches.
Tuanlao, Wang +2 more
openaire +2 more sources
Epileptic Phenotypes Associated With SNAREs and Related Synaptic Vesicle Exocytosis Machinery
Frontiers in Neurology, 2022 SNAREs (soluble N-ethylmaleimide sensitive factor attachment protein receptor) are an heterogeneous family of proteins that, together with their key regulators, are implicated in synaptic vesicle exocytosis and synaptic transmission. SNAREs represent the
Elisa Cali +3 more
doaj +1 more source
A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes
Cell & Bioscience, 2023 Background People of Sub-Saharan African ancestry are at higher risk of developing chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (APOL1) gene risk alleles (RA) G1 and G2. The underlying mechanisms by which the APOL1-RA precipitate CKD
Jin-Gu Lee +6 more
doaj +1 more source