Results 91 to 100 of about 15,713 (203)

Neuronal activity triggers secretory autophagy to mediate the extracellular release of SNCA/α-synuclein

Autophagy Reports
Autophagy has two distinct pathways, degradation and secretion. Autophagic degradation plays a pivotal role in cellular homeostasis by the formation of a double-membrane autophagosome in concert with numerous ATG (autophagy-related) proteins.
Yoshitsugu Nakamura, Shigeki Arawaka
doaj   +1 more source

From regulatory mechanisms to cutting‐edge applications: Research progress of ultrasound, electrical, magnetic, and optical stimulation in neural modulation

Journal of Intelligent Medicine, Volume 3, Issue 3, Page 196-219, September 2026.
Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley   +1 more source

LncRNA-UCA1 promotes PD development by upregulating SNCA.

European review for medical and pharmacological sciences, 2018
The study aims to investigate whether Long non-coding RNA (LncRNA)-UCA1 can regulate the progression of Parkinson's disease (PD) by mediating a-synuclein (SNCA) expression.PD mouse model was first constructed by intraperitoneal injection of MPTP. SH-SY5Y cells were treated with MPP+ for inducing in vitro PD model.
Lu, M., Sun, W.-L., Shen, J., Wei, M., Chen, B., Qi, Y.-J., Xu, C.-S.   +6 more
openaire   +2 more sources

SNCA-AS1 in aging and Parkinson’s disease

Aging, 2022
Carelli, Stefana, Rey, Federica, Cereda, Cristina   +2 more
openaire   +2 more sources

The alpha-synuclein antisense transcript SNCA-AS1 is implicated in Parkinson’s Disease: role in synaptogenesis and aging-related pathways

, 2021
SNCA protein product, alpha-synuclein, is widely renowned for its implication in both aging and Parkinson’s Disease, but research efforts are still needed to elucidate its physiological functions and regulation.
Cecilia Pandini, Gian Vincenzo Zuccotti, Federica Rey, Roberta Zangaglia, Letizia Messa, Cristina Cereda, Stella Gagliardi, Stefana Carelli   +7 more
core   +1 more source

Genetic Variants in SNCA and the Risk of Sporadic Parkinson’s Disease and Clinical Outcomes: A Review

Parkinson's Disease, 2017
There is increasing evidence of the contribution of genetic susceptibility to the etiology of Parkinson’s disease (PD). Genetic variations in the SNCA gene are well established by linkage and genome-wide association studies.
Clarissa Loureiro das Chagas Campêlo, Regina Helena Silva   +1 more
doaj   +1 more source

Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse

Neurobiology of Disease, 2014
Parkinson's disease (PD) is a neurodegenerative disorder classically characterized by the death of dopamine (DA) neurons in the substantia nigra pars compacta and by intracellular Lewy bodies composed largely of α-synuclein.
Tonya N. Taylor, Dawid Potgieter, Sabina Anwar, Steven L. Senior, Stephanie Janezic, Sarah Threlfell, Brent Ryan, Laura Parkkinen, Thierry Deltheil, Milena Cioroch, Achilleas Livieratos, Peter L. Oliver, Katie A. Jennings, Kay E. Davies, Olaf Ansorge, David M. Bannerman, Stephanie J. Cragg, Richard Wade-Martins   +17 more
doaj   +1 more source

A Review on the Role of SNCA Gene in Neurodegenerative Diseases

Cureus
Gene variations significantly impact the development of neurodegenerative disorders, particularly Alzheimer's disease (AD) and Parkinson's disease (PD). In AD, which is marked by amyloid-beta (Aβ) plaques and tau tangles, key genetic contributors such as amyloid beta precursor protein (APP), presenilin (PSEN1), and presenilin 2 (PSEN2) play a ...
Jahabardeen, Afrarahamed, S, Nirenjen, J, Narayanan, V, Chitra   +3 more
openaire   +2 more sources

Alpha-synuclein A53T mutation is not frequent on a sample of Brazilian Parkinson’s disease patients

Arquivos de Neuro-Psiquiatria, 2015
Introduction The pathogenesis of Parkinson’s disease (PD) involves both genetic susceptibility and environmental factors, with focus on the mutation in the alpha-synuclein gene (SNCA).Objective To analyse the polymorphism SNCA-A53T in patients with ...
Gabriela S. Longo, Marcela A. S. Pinhel, Michele L. Gregório, Bruno A. P. Oliveira, Driele C. G. Quinhoneiro, Waldir A. Tognola, Fábio N. Oliveira, Sabrina M.Cezario, Caroline L. Sado, Marcelo A. Nakazone, Maria C. J. Calastri, Dorotéia R. S. Souza   +11 more
doaj   +1 more source

Young human alpha synuclein transgenic (BAC-SNCA) mice display sex- and gene-dose-dependent phenotypic disturbances [PDF]

Parkinson’s disease (PD) is a common neurodegenerative movement disorder, characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta and the accumulation of aggregated alpha synuclein (aSyn).
Moceri, Sandra, Timotius, Ivanna K., Bluhm, Alexandra, Hörsten, Stephan von, Ratz-Wirsching, Veronika, Harrer, Julia, Distler, Jörg, Bäuerle, Natascha, Xiang, Wei, Hartlage-Rübsamen, Maike, Winkler, Jürgen, Roßner, Steffen, Schulze-Krebs, Anja, Habermeyer, Johanna   +13 more
core   +1 more source