Results 101 to 110 of about 15,713 (203)

Analysis of α-syn and parkin interaction in mediating neuronal death in Drosophila model of Parkinson's disease

Frontiers in Cellular Neuroscience
One of the hallmarks of Parkinson's Disease (PD) is aggregation of incorrectly folded α-synuclein (SNCA) protein resulting in selective death of dopaminergic neurons.
Sonia Narwal, Amit Singh, Meghana Tare
doaj   +1 more source

Expansion of the Parkinson disease-associated SNCA- Rep1 allele upregulates human α-synuclein in transgenic mouse brain [PDF]

, 2009
Alpha-synuclein (SNCA) gene has been implicated in the development of rare forms of familial Parkinson disease (PD). Recently, it was shown that an increase in SNCA copy numbers leads to elevated levels of wild-type SNCA-mRNA and protein and is ...
Linnertz, Colton, Schlossmacher, Michael G, Chiba-Falek, Ornit, Orrison, Bonnie M, El-Agnaf, Omar MA, Cronin, Kenneth D, Rossoshek, Anna, Ge, Dongliang, Nussbaum, Robert L, Bernard, David J, Manninger, Paul   +10 more
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Targeting SNCA in the treatment of malignant ascites in gastrointestinal cancer

Translational Oncology
Peritoneal tumor dissemination and subsequent malignant tumor ascites (MTA) occur unexpectedly and repeatedly in patients with gastrointestinal (GI) cancers, and worsen quality of life and prognosis of the patients. Various treatments have been clinically developed for these patients, while most of the MTA cases are refractory to the treatments.
Chie Kudo-Saito, Hiroshi Imazeki, Hiroki Ozawa, Hirofumi Kawakubo, Hidekazu Hirano, Narikazu Boku, Ken Kato, Hirokazu Shoji   +7 more
openaire   +3 more sources

Vimentin network dysregulation mediates neurite deficits in SNCA duplication Parkinson’s patient–derived midbrain neurons

Duplication of the SNCA gene (SNCA(Dupl)), linked to elevated levels of α-synuclein (aSyn), is a genetic cause of Parkinson’s disease (PD). Our prior work with human-induced pluripotent stem cell (hiPSC)–derived midbrain neurons generated from patients ...
Schneider, Yanni, Xiang, Wei, Koller, Aron, Schweigert, Alina, Hoffmann, Laura, Plötz, Sonja, Winkler, Jürgen, Andert, Marie, Seebauer, Lukas, O’Brien, Sydney, Kielkowski, Pavel, Schlachetzki, Johannes C. M.   +11 more
core   +1 more source

α-Synuclein (SNCA) [PDF]

Science-Business eXchange, 2009
openaire   +3 more sources

SNCA Gene [PDF]

, 2020
openaire   +1 more source

Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology

Molecular Neurodegeneration
The autophagy-lysosomal pathway is crucial for maintaining homeostasis and survival of neurons, hence defects in this system have been associated with neurodegeneration, including Parkinson's disease (PD).
Denise Balta, Anish Varghese, Susy Prieto Huarcaya, Alessandro Di Spiezio, André R. A. Marques, Enes Yağız Akdaş, Doğa Tabakacilar, Alice Drobny, Christian Werner, Wei Xiang, Rebecca Mächtel, Jan Philipp Dobert, Anna Fejtova, Franziska Richter, Melanie Küspert, Philipp Arnold, Paul Saftig, Friederike Zunke   +17 more
doaj   +1 more source

Effective lowering of α-synuclein expression by targeting G-quadruplex structures within the SNCA gene

Alpha-synuclein, encoded by the SNCA gene, is a pivotal protein implicated in the pathogenesis of synucleinopathies, including Parkinson's disease. Current approaches for modulating alpha-synuclein levels involve anti- sense nucleotides, siRNAs, and ...
Esposito L., Pansarasa O., Mella M., Maghraby E., Pirota V., Doria F., Gandellini P., Carelli S., Di Gerlando R., Pandini C., Cereda C., Freccero M., Rey F., Fantini V.   +13 more
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SNCA wt Allele [PDF]

, 2020
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α-Synuclein (SNCA) [PDF]

Science-Business eXchange, 2013
openaire   +1 more source