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The Transcriptional Co-Activator SND1 Is a Novel Regulator of Alternative Splicing in Prostate Cancer Cells [PDF]

Oncogene, 2014
Splicing abnormalities have profound impact in human cancer. Several splicing factors, including SAM68, have pro-oncogenic functions, and their increased expression often correlates with human cancer development and progression.
Maria Paola Paronetto, Fabiola Ciccosanti, Claudio Sette   +2 more
exaly   +2 more sources

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Prognostic impact of Metadherin–SND1 interaction in colon cancer

Molecular Biology Reports, 2012
The interaction between Metadherin (MTDH) and Staphylococcal nuclease homology domain containing 1 (SND1) is involved in tumorigenesis and tumor progression of several human malignancies. However, its roles in colon cancer are still unclear. To investigate the clinical value of MTDH and SND1 expression in colon cancer.
Nan, Wang, Xilin, Du, Li, Zang, Nuan, Song, Tao, Yang, Rui, Dong, Tao, Wu, Xianli, He, Jianguo, Lu   +8 more
openaire   +2 more sources

MicroRNA, SND1, and alterations in translational regulation in colon carcinogenesis

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2010
Post-transcriptional regulation of gene expression by microRNA (miRNA) has recently attracted major interest in relation to its involvement in cancer development. miRNA is a member of small non-coding RNA, consists of 22-24 nucleotides and regulates expression of target mRNA species in a post-transcriptional manner by being incorporated with RNA ...
Naoto, Tsuchiya, Hitoshi, Nakagama
openaire   +2 more sources

1447-P: The Snd1 Coregulator Controls ß-Cell Function

Diabetes, 2022
The main function of the pancreatic β-cell is glucose-stimulated insulin secretion (GSIS) which serves to maintain whole body glucose homeostasis. Under type 2 diabetic conditions, a subset of β-cells fail and lose expression of key transcription factors (TFs) required for GSIS.
SUKRATI KANOJIA, REBECCA K. DAVIDSON, JASON SPAETH, NOLAN CASEY   +3 more
openaire   +1 more source

Association of SND1 protein to low density lipid droplets in liver steatosis

Journal of Physiology and Biochemistry, 2010
Although the human homologue of SND p102, p100 coactivator, was initially described as a nuclear protein, the p100 coactivator protein family members have non-nuclear localization in mammalian cells with active lipid handling, storage, and secretion. However, their role in lipid homeostasis remains unresolved.
I, Garcia-Arcos, Y, Rueda, P, González-Kother, L, Palacios, B, Ochoa, O, Fresnedo   +5 more
openaire   +2 more sources

Protective Effects of SND1 in Retinal Photoreceptor Cell Damage Induced by Ionizing Radiation

Biochemical and Biophysical Research Communications, 2019
Staphylococcal nuclease and tudor domain containing 1 (SND1) has multiple functions in a variety of cellular processes. Here, we assessed the effects of SND1 in cellular DNA damage after ionizing radiation (IR). Knocking down SND1 in the mouse-derived photoreceptor 661 W cell line markedly inhibited cell proliferation and increased apoptosis after IR ...
Mengying Zhai, Xuyang Yao
exaly   +3 more sources

NF-κB, Sp1 and NF-Y as Transcriptional Regulators of Human SND1 Gene

Biochimie, 2013
Staphylococcal nuclease domain-containing protein 1 (SND1), also called Tudor-SN, is required for many biological events ranging from gene expression to cell growth regulation. Promoter regulation of SND1 gene and its molecular mechanism have remained elusive to date.
Maria José Martinez, Begoña Ochoa
exaly   +3 more sources

LincRNA TINCR facilitates excessive proliferation and inflammation in post-burn skin fibroblasts by directly binding with SND1 protein and inducing SND1-mediated TGF-β1 expression

Biochemical and Biophysical Research Communications, 2019
In this study, we found that lincRNA-TINCR was significantly upregulated in burn-injured skin tissues in vivo and heat-stimulated dermal fibroblasts in vitro, accompanied by an increase in TGF-β1 expression. TINCR overexpression promoted cell proliferation, colony formation, release of pro-inflammatory factors and expression of TGF-β1 protein in human ...
Gaoping, Qin, Yong, Song, Yadong, Guo, Yaowen, Sun, Weihui, Zeng   +4 more
openaire   +2 more sources

SUMOylation of SND1 drives mature miRNA degradation and tumor progression

Cancer Letters
The global downregulation of microRNAs (miRNAs) is a hallmark of many cancers, yet the mechanisms governing mature miRNA degradation remain poorly understood. Post-translational modifications (PTMs) have emerged as key regulators of RNA metabolism. However, the specific role of stress-responsive PTMs in driving miRNA degradation within the complex ...
Yingting Cao, Yanli Wang, Xindi Zhang, Yixin Zhang, Xintong Zhang, Xiaopeng Tan, Lian Li, Ran Chen, Runhui Lu, Ruiyu Xie, Jianxiu Yu, Xiaojing Zhao   +11 more
openaire   +2 more sources

Breaking up MTDH–SND1 to break down metastasis

Nature Cancer, 2022
Qingwen Jiang, Karuna Ganesh
openaire   +2 more sources