Results 61 to 70 of about 20,822 (255)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Influencer marketing meets consumer protection : the role of the rules on unfair commercial practices in regulating social media influencers [PDF]

This chapter examines the extent to which social media influencers are subject to the rules on unfair commercial practices when they promote third-party traders’ products to their followers.
Kerckaert, JulieRE210001409642388020035495290009-0006-9000-22464C71A69E-3DED-11E4-8AC5-DAE6B4D1D7B1, Geiregat, SimoneditorRE210001000520628020017834220000-0002-5614-18792811D466-F0EE-11E1-A9DE-61C894A0A6B4, Kerckaert, JulieeditorRE210001409642388020035495290009-0006-9000-22464C71A69E-3DED-11E4-8AC5-DAE6B4D1D7B1   +2 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The health paradoxes of social media influencers [Elektronisk resurs] [PDF]

This paper describes and discusses social media influencers’ health-related costs of keeping traction as influencers. The paper is based on interviews and social media posts.
Mileros, Martin Daniel, Öberg, Christina, Öberg, Christina,, Norrman, Charlotte, Mileros, Martin Daniel,, Norrman, Charlotte,, Mileros, Martin   +6 more
core   +1 more source

From cultural intermediaries to social media influencers: algorithms and taste in social media platforms [PDF]

, 2021
Social media and digital environments have shaped the consumer consumption habits and the world of marketing for good. This literature review studies how has the phenomena of social media influencers emerged from the origins of cultural intermediaries in
Mertaniemi, Tea
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Meeting people where they are: leveraging influencers’ social capital and trust to promote safer behaviours [PDF]

The newfound authority of social media ‘Content Creators’ or ‘Influencers’ (hereon referred to as influencers) have changed the media landscape in a short space of time.
Peden, Amy E, Piatkowski, Timothy, Cornell, Samuel, Taba, Melody   +3 more
core   +1 more source

A Netnography Study of the Social Media Influencers on Creating Netizens' Climate Change Awareness on Instagram [PDF]

, 2019
Climate change is one of the United Nations (UN) programs, as stated in the Sustainable Development Goals (SDGs). Geographically, Indonesia is located in the equator area, including a quite vulnerable country, so it is necessary to build netizens ...
Murwani, Endah, Ariestya, Angga, Juliadi, Rismi   +2 more
core   +1 more source