Results 71 to 80 of about 511,275 (351)
The Emerging Chondrocyte Channelome
Frontiers in Physiology, 2010 Chondrocytes are the resident cells of articular cartilage and are responsible for synthesising a range of collagenous and non-collagenous extracellular matrix macromolecules.
Richard Barrett-Jolley +3 more
doaj +1 more source
Ion channels in lung cancer: biological and clinical relevance
Frontiers in Pharmacology, 2023 Despite improvements in treatment, lung cancer is still a major health problem worldwide. Among lung cancer subtypes, the most frequent is represented by adenocarcinoma (belonging to the Non-Small Cell Lung Cancer class) although the most challenging and
Chiara Capitani +6 more
doaj +1 more source
Energy-efficient coding with discrete stochastic events [PDF]
, 2002 We investigate the energy efficiency of signaling mechanisms that transfer information by means of discrete stochastic events, such as the opening or closing of an ion channel.
Herz, Andreas V. M. +3 more
core +2 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Energetics of ion competition in the DEKA selectivity filter of neuronal sodium channels [PDF]
, 2015 The energetics of ionic selectivity in the neuronal sodium channels is studied. A simple model constructed for the selectivity filter of the channel is used.
Boda, D. +3 more
core +4 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Predicting Structural Details of the Sodium Channel Pore Basing on Animal Toxin Studies
Frontiers in Pharmacology, 2018 Eukaryotic voltage-gated sodium channels play key roles in physiology and are targets for many toxins and medically important drugs. Physiology, pharmacology, and general architecture of the channels has long been the subject of intensive research in ...
Denis B. Tikhonov +2 more
doaj +1 more source
Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel [PDF]
, 2013 The crystal structure of the open conformation of a bacterial voltage-gated sodium channel pore from Magnetococcus sp. (NaVMs) has provided the basis for a molecular dynamics study defining the channel’s full ion translocation pathway and conductance ...
Bagneris, Claire +7 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
VOLTAGE-GATED SODIUM CHANNELS AND CANCER: IS EXCITABILITY THEIR PRIMARY ROLE?
Frontiers in Pharmacology, 2015 Voltage-gated sodium channels (NaV) are molecular characteristics of excitable cells. Their activation, triggered by membrane depolarization, generates transient sodium currents that initiate action potentials in neurons and muscle cells. Sodium currents
Sébastien eRoger +3 more
doaj +1 more source