Molecules, 2022 The hybrid peptides consisting of α and β-amino acids show great promise as peptidomimetics that can be used as therapeutic agents. Therefore, the development of new unnatural amino acids and the methods of their incorporation into the peptide chain is ...
Urszula Bąchor +3 more
doaj +1 more source
Deprotection Reagents in Fmoc Solid Phase Peptide Synthesis: Moving Away from Piperidine? [PDF]
Molecules, 2016 The deprotection step is crucial in order to secure a good quality product in Fmoc solid phase peptide synthesis. 9-Fluorenylmethoxycarbonyl (Fmoc) removal is achieved by a two-step mechanism reaction favored by the use of cyclic secondary amines ...
Luna OF +5 more
europepmc +2 more sources
Ugi multicomponent reaction to prepare peptide–peptoid hybrid structures with diverse chemical functionalities [PDF]
, 2018 Monodisperse sequenced peptides and peptoids present unique nano-structures based on their self-assembled secondary and tertiary structures. However, the generation of peptide and peptoid hybrid oligomers in a sequence-defined manner via Ugi ...
Azevedo, Helena S. +12 more
core +1 more source
HOBt·DCHA-Mediated Synthesis of Sterically Hindered Peptides employing Fmoc-Amino Acid Chlorides in Both Solution-Phase and Solid Phase Methods [PDF]
, 2008 The synthesis of peptides employing Fmoc-amino acid chlorides in presence of HOBt·DCHA salt in solution as well as by the solid-phase methods is described. The coupling was found to be complete in 30 min and free from racemization.
Krishna, G.C. +2 more
core +1 more source
Greening Fmoc/tBu solid-phase peptide synthesis
, 2020 Peptides are gaining considerable attention as potential drugs. The so-called Fmoc/tBu solid-phase synthesis is the method of choice for the synthesis of these molecules in both research and industrial settings.
Othman Al Musaimi +2 more
semanticscholar +1 more source
Synthesis and cellular penetration properties of new phosphonium based cationic amphiphilic peptides [PDF]
, 2018 A new category of phosphonium based cationic amphiphilic peptides has been developed and evaluated as potential antimicrobial peptides and cell penetrating peptides.
Gannon, Susan +7 more
core +1 more source
Solid Phase versus Solution Phase Synthesis of Heterocyclic Macrocycles
Molecules, 2013 Comparing a solution phase route to a solid phase route in the synthesis of the cytotoxic natural product urukthapelstatin A (Ustat A) confirmed that a solid phase method is superior.
Shelli R. McAlpine, Seong Jong Kim
doaj +1 more source
Peptide-directed crystal growth modification in the formation of ZnO [PDF]
, 2015 Biomolecule-mediated synthesis is fascinating in terms of the level of control and the intricate hierarchical structures of the materials that can be produced.
Liang, M-K +3 more
core +1 more source
Epimerisation in Peptide Synthesis
Molecules, 2023 Epimerisation is basically a chemical conversion that includes the transformation of an epimer into another epimer or its chiral partner. Epimerisation of amino acid is a side reaction that sometimes happens during peptide synthesis.
Suleman Duengo +4 more
doaj +1 more source
Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]
, 2011 Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Troiber, Christina, Wagner, Ernst
core +1 more source