Results 1 to 10 of about 1,137,713 (279)

Heterocycles as a Peptidomimetic Scaffold: Solid-Phase Synthesis Strategies [PDF]

Pharmaceuticals, 2021
Peptidomimetics are a privileged class of pharmacophores that exhibit improved physicochemical and biological properties. Solid-phase synthesis is a powerful tool for gaining rapid access to libraries of molecules from small molecules to biopolymers and ...
Aizhan Abdildinova, Mark J. Kurth, Young-Dae Gong   +2 more
doaj   +2 more sources

Dielectrophoretic bead-droplet reactor for solid-phase synthesis [PDF]

Nature Communications
Solid-phase synthesis underpins many advances in synthetic and combinatorial chemistry, biology, and material science. The immobilization of a reacting species on the solid support makes interfacing of reagents an important challenge in this approach. In
Punnag Padhy, Mohammad Asif Zaman, Michael Anthony Jensen, Yao-Te Cheng, Yogi Huang, Mo Wu, Ludwig Galambos, Ronald Wayne Davis, Lambertus Hesselink   +8 more
doaj   +2 more sources

The Facile Solid-Phase Synthesis of Thiazolo-Pyrimidinone Derivatives [PDF]

Molecules
A thiazolo-pyrimidinone derivative library was developed through a facile solid-phase synthesis method. For the reaction, the thiazolo[4,5-d]pyrimidin-7(6H)-one structure was synthesized through efficient Thorpe–Ziegler and cyclization reactions.
Shuanghui Hua, Jimin Moon, Taeho Lee
doaj   +2 more sources

Solid-phase synthesis of duocarmycin analogues and the effect of C-terminal substitution on biological activity [PDF]

, 2015
YesThe duocarmycins are potent antitumour agents with potential in the development of antibody drug conjugates (ADCs) as well as being clinical candidates in their own right.
Adcock, C., Collingwood, S.P., Fox, K.R., Howell, L.A., Kingston, J., O'Connell, M.A., Pors, Klaus, Searcey, M., Sheldrake, Helen M., Stephenson, M.J.   +9 more
core   +4 more sources

Laser solid-phase synthesis of single-atom catalysts [PDF]

Light: Science & Applications, 2021
Synthesis of Pt single atom catalysts is achieved by one-step laser irradiation of “isolated” H2PtCl6 precursor on graphene oxide, via filtration and freeze-drying sublimation, by simultaneous pyrolysis of the precursor and reduction of graphene oxide.
Yudong Peng, Jianyun Cao, Yang Sha, Wenji Yang, Lin Li, Zhu Liu   +5 more
doaj   +2 more sources

Solid-phase-assisted synthesis of targeting peptide-PEG-oligo(ethane amino)amides for receptor-mediated gene delivery. [PDF]

, 2012
In the forthcoming era of cancer gene therapy, efforts will be devoted to the development of new efficient and non-toxic gene delivery vectors. In this regard, the use of Fmoc/Boc-protected oligo(ethane amino)acids as building blocks for solid-phase ...
Akinc, Aumailley, Behr, Blessing, Boussif, Breunig, Carlos Mas-Moruno, Chollet, Christian Dohmen, Christina Troiber, Cotten, Cox, David Schaffert, Davis, Davis, Dechantsreiter, Desgrosellier, Drake, Edinger, Ellman, Erbacher, Ernest Giralt, Ernst Wagner, Felding-Habermann, Felgner, Fella, Grandinetti, Harbottle, Hartmann, Hartmann, Haubner, Horst Kessler, Irene Martin, J., Kantlehner, Kichler, Kim, Kursa, Li, Lin, Luthman, Madder, Mas-Moruno, McKenzie, Meritxell Teixidó, Merkel, Meyer, Meyer, Michael Günther, Moghimi, Mosca, Nie, Oba, Oupicky, Pack, Petra Kos, Pfaff, Plank, Reis, Ruoslahti, Russ, Russ, Schaffert, Schaffert, Schaffert, Schiffelers, Sonawane, Trubetskoy, Ulrich Lächelt, Varkouhi, Wagner, Wagner, Wagner, Wagner, Walker, Wu, Xia, Xu, Zintchenko   +78 more
core   +5 more sources

Iodo Silanes as Superior Substrates for the Solid Phase Synthesis of Molecularly Imprinted Polymer Nanoparticles. [PDF]

Polymers (Basel), 2022
Piletsky SS, Garcia Cruz A, Piletska E, Piletsky SA, Aboagye EO, Spivey AC.   +5 more
europepmc   +3 more sources

Solid-Phase Synthesis of Titanium Dioxide Micro-Nanostructures. [PDF]

ACS Omega, 2022
Han XH, Li CQ, Tang P, Feng CX, Yue XZ, Zhang WL.   +5 more
europepmc   +2 more sources

Development of Rapid and Facile Solid-Phase Synthesis of PROTACs via a Variety of Binding Styles. [PDF]

ChemistryOpen, 2022
Xu H, Kurohara T, Takano R, Yokoo H, Shibata N, Ohoka N, Inoue T, Naito M, Demizu Y.   +8 more
europepmc   +2 more sources

The interplay between thermodynamics and kinetics in the solid-state synthesis of layered oxides. [PDF]

, 2020
In the synthesis of inorganic materials, reactions often yield non-equilibrium kinetic byproducts instead of the thermodynamic equilibrium phase. Understanding the competition between thermodynamics and kinetics is a fundamental step towards the rational
Bai, Jianming, Bianchini, Matteo, Ceder, Gerbrand, Clément, Raphaële J, Kim, Haegyeom, Kitchaev, Daniil, Ouyang, Bin, Shi, Tan, Sun, Wenhao, Wang, Feng, Wang, Jingyang, Wang, Yan, Xiao, Penghao, Zhang, Mingjian, Zhang, Yaqian   +14 more
core   +1 more source