Results 1 to 10 of about 1,086,340 (247)
Novel Solution- and Solid-Phase Strategies for the Parallel and Combinatorial Synthesis of Small-Molecular-Weight Compound Libraries [PDF]
CHIMIA, 1996 In this account dedicated to '100 years Roche' in CHIMIA, we present some of our strategies towards the synthesis of interesting novel amino-acid-derived building blocks; multigeneration synthesis of thiazole libraries in solution; a novel solid-
Alexander Chucholowski +4 more
doaj +6 more sources
Solid-Phase Synthesis of s-Tetrazines. [PDF]
Org Lett, 2023 An efficient synthesis of s-tetrazines by solid-phase methods is described. This synthesis route was compatible with different solid-phase resins and linkers and did not require metal catalysts or high temperatures. Monosubstituted tetrazines were routinely synthesized using thiol-promoted chemistry, using dichloromethane as a carbon source, while ...
Alghamdi ZS +4 more
europepmc +5 more sources
SASRIN™ a Versatile Tool in Peptide Synthesis and Solid-Phase Organic Chemistry [PDF]
CHIMIA, 1999 The synthesis of the 4-(3-methoxy-4-(hydroxymethyl)phenoxymethyl) derivative of polystyrene-co-divinylbenzene (SASRIN™), its derivatives and its application in solid-phase peptide synthesis will be briefly reviewed in this paper.
Monika Mergler +4 more
doaj +3 more sources
Heterocycles as a Peptidomimetic Scaffold: Solid-Phase Synthesis Strategies [PDF]
Pharmaceuticals, 2021 Peptidomimetics are a privileged class of pharmacophores that exhibit improved physicochemical and biological properties. Solid-phase synthesis is a powerful tool for gaining rapid access to libraries of molecules from small molecules to biopolymers and ...
Aizhan Abdildinova +2 more
doaj +2 more sources
Dielectrophoretic bead-droplet reactor for solid-phase synthesis [PDF]
Nature CommunicationsSolid-phase synthesis underpins many advances in synthetic and combinatorial chemistry, biology, and material science. The immobilization of a reacting species on the solid support makes interfacing of reagents an important challenge in this approach. In
Punnag Padhy +8 more
doaj +2 more sources
Parallel solid-phase synthesis of diaryltriazoles [PDF]
Beilstein Journal of Organic Chemistry, 2012 A series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper(I)- or ruthenium(II)-catalyzed 1,3-cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a ...
Matthias Wrobel +2 more
doaj +5 more sources
The Facile Solid-Phase Synthesis of Thiazolo-Pyrimidinone Derivatives [PDF]
MoleculesA thiazolo-pyrimidinone derivative library was developed through a facile solid-phase synthesis method. For the reaction, the thiazolo[4,5-d]pyrimidin-7(6H)-one structure was synthesized through efficient Thorpe–Ziegler and cyclization reactions.
Shuanghui Hua, Jimin Moon, Taeho Lee
doaj +2 more sources
Solid-Phase Synthesis of Megamolecules. [PDF]
J Am Chem Soc, 2020 This paper presents a solid-phase strategy to efficiently assemble multiprotein scaffolds-known as megamolecules-without the need for protecting groups and with precisely defined nanoscale architectures. The megamolecules are assembled through sequential reactions of linkers that present irreversible inhibitors for enzymes and fusion proteins ...
Kimmel BR +4 more
europepmc +5 more sources
Solid-phase synthesis of glicosaminoglycans [PDF]
, 2017 330 p.Glycosaminoglycans (GAGs) are highly charged and linear polysaccharide repeating units (with the exception of keratin sulfate), which are further classified according their monosaccharide composition and glycosidic linkage. They are present on most
Guedes Carrerra, Nerea
core +3 more sources
Laser solid-phase synthesis of single-atom catalysts [PDF]
Light: Science & Applications, 2021 Synthesis of Pt single atom catalysts is achieved by one-step laser irradiation of “isolated” H2PtCl6 precursor on graphene oxide, via filtration and freeze-drying sublimation, by simultaneous pyrolysis of the precursor and reduction of graphene oxide.
Yudong Peng +5 more
doaj +2 more sources