Results 1 to 10 of about 1,115,644 (325)
Solid-Phase Synthesis of s-Tetrazines. [PDF]
Org Lett, 2023 An efficient synthesis of s-tetrazines by solid-phase methods is described. This synthesis route was compatible with different solid-phase resins and linkers and did not require metal catalysts or high temperatures. Monosubstituted tetrazines were routinely synthesized using thiol-promoted chemistry, using dichloromethane as a carbon source, while ...
Alghamdi ZS +4 more
europepmc +5 more sources
Heterocycles as a Peptidomimetic Scaffold: Solid-Phase Synthesis Strategies [PDF]
Pharmaceuticals, 2021 Peptidomimetics are a privileged class of pharmacophores that exhibit improved physicochemical and biological properties. Solid-phase synthesis is a powerful tool for gaining rapid access to libraries of molecules from small molecules to biopolymers and ...
Aizhan Abdildinova +2 more
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CHIMIA, 1996 In this account dedicated to '100 years Roche' in CHIMIA, we present some of our strategies towards the synthesis of interesting novel amino-acid-derived building blocks; multigeneration synthesis of thiazole libraries in solution; a novel solid-
Alexander Chucholowski +4 more
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Dielectrophoretic bead-droplet reactor for solid-phase synthesis [PDF]
Nature CommunicationsSolid-phase synthesis underpins many advances in synthetic and combinatorial chemistry, biology, and material science. The immobilization of a reacting species on the solid support makes interfacing of reagents an important challenge in this approach. In
Punnag Padhy +8 more
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Parallel solid-phase synthesis of diaryltriazoles [PDF]
Beilstein Journal of Organic Chemistry, 2012 A series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper(I)- or ruthenium(II)-catalyzed 1,3-cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a ...
Matthias Wrobel +2 more
doaj +5 more sources
The Facile Solid-Phase Synthesis of Thiazolo-Pyrimidinone Derivatives [PDF]
MoleculesA thiazolo-pyrimidinone derivative library was developed through a facile solid-phase synthesis method. For the reaction, the thiazolo[4,5-d]pyrimidin-7(6H)-one structure was synthesized through efficient Thorpe–Ziegler and cyclization reactions.
Shuanghui Hua, Jimin Moon, Taeho Lee
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Laser solid-phase synthesis of single-atom catalysts [PDF]
Light: Science & Applications, 2021 Synthesis of Pt single atom catalysts is achieved by one-step laser irradiation of “isolated” H2PtCl6 precursor on graphene oxide, via filtration and freeze-drying sublimation, by simultaneous pyrolysis of the precursor and reduction of graphene oxide.
Yudong Peng +5 more
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Solid‐Phase Supports for Oligonucleotide Synthesis [PDF]
Current Protocols in Nucleic Acid Chemistry, 2000 AbstractThis unit begins with a discussion of the advantages and disadvantages of oligonucleotide synthesis using solid supports. The physical and chemical properties of solid‐phase supports are discussed in terms of their suitability for oligonucleotide synthesis. In addition, the unit outlines the properties of linkers used for transient or permanent
Richard T. Pon
openalex +7 more sources
Grafted supports in solid-phase synthesis [PDF]
Biopolymers, 2000 Solid-phase synthesis is greatly dependent on the solid phase. We are interested in the development of a "pellicular" type of solid support where a more mobile polymer is grafted to rigid plastics. Compared to low cross-linked microporous beads that dominate the field, this approach allows great flexibility of design, as plastics are available as ...
Firas Rasoul +8 more
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Synlett, 1998 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Harry C. J. Ottenheijm +3 more
openaire +2 more sources