Results 21 to 30 of about 778,801 (197)

A novel and alternative approach to controlled release drug delivery system based on solid dispersion technique

Bulletin of Faculty of Pharmacy Cairo University, 2012
The solid dispersion method was originally used to improve the dissolution properties and the bioavailability of poorly water soluble drugs by dispersing them into water soluble carriers.
Tapan Kumar Giri, Kulesh Kumar, Amit Alexander, Ajazuddin, Hemant Badwaik, Dulal Krishna Tripathi   +5 more
doaj   +1 more source

The Amorphous Solid Dispersion of Chrysin in Plasdone^® S630 Demonstrates Improved Oral Bioavailability and Antihyperlipidemic Performance in Rats

Pharmaceutics, 2023
Chrysin is a flavonoid with various biological activities. However, its low water solubility and strong metabolism render its oral bioavailability rather poor.
Chenhui Wang, Xiaowei Liu, Ruihan Zhao, Meiqing Yang, Wenqian Liu, Qiuyang Dai, Xiaofeng Bao, Yong Chen, Jun Ma   +8 more
doaj   +1 more source

Composition and Technology Development for Obtaining Amorphous Solid Dispersion of Ebastine by Hot Melt Extrusion to Increase Dissolution Rate

Разработка и регистрация лекарственных средств, 2023
Introduction. Ebastine is a second-generation antihistamine drug available in the form of orally disintegrating tablets and film-coated tablets. Ebastine substance exhibits high bioavailability, but low solubility in water and gastrointestinal tract ...
K. A. Gusev, A. R. Aliev, Yu. E. Generalova, N. A. Aksenova, G. V. Rechkalov, D. N. Maimistov, G. M. Alekseeva, E. V. Flisyuk   +7 more
doaj   +1 more source

Thermal phonon boundary scattering in anisotropic thin films [PDF]

, 2015
Boundary scattering of thermal phonons in thin solid films is typically analyzed using Fuchs-Sondheimer theory, which provides a simple equation to calculate the reduction of thermal conductivity as a function of the film thickness.
Minnich, Austin J.
core   +3 more sources

DEVELOPMENT OF SUSTAINED RELEASE TABLETS CONTAINING SOLID DISPERSIONS OF BACLOFEN [PDF]

Journal of Fundamental and Applied Sciences, 2013
Sustained release tablets containing solid dispersions granules of a poorly water soluble drug were prepared to investigate the controlled release of the drug.
K. H. Janardhana, R. Deveswaran, S. Bharath, B.V. Basavaraj, V. Madhavan   +4 more
doaj  

Studies on Dissolution Enhancement of Prednisolone, a Poorly Water-Soluble Drug by Solid Dispersion Technique [PDF]

, 2011
Introduction: Prednisolone is a class II substance according to the Biopharmaceutics Classification System. It is a poorly water soluble agent. The aim of the present study was to improve dissolution rate of a poorly water-soluble drug, prednisolone, by ...
Ali Nokhodchi, Hadi Valizadeh, Leila Mohammadi, Mohammad Barzegar-Jalali, Parvin Zakeri-Milani, Somayeh Hallaj Nezhadi   +5 more
core   +2 more sources

Calculating NMR parameters in aluminophosphates : evaluation of dispersion correction schemes [PDF]

, 2014
Periodic density functional theory (DFT) calculations have recently emerged as a popular tool for assigning solid-state nuclear magnetic resonance (NMR) spectra. However, in order for the calculations to yield accurate results, accurate structural models
Ashbrook, Sharon E., Dawson, Daniel M., Pickard, Chris J., Sneddon, Scott   +3 more
core   +2 more sources

From colloidal dispersions to colloidal pastesthrough solid–liquid separation processes [PDF]

, 2005
Solid–liquid separation is an operation that starts with a dispersion of solid particles in a liquid and removes some of the liquid from the particles, producing a concentrated solid paste and a clean liquid phase.
Botet, Robert, Cabane, Bernard, Madeline, J.B., Martin, Céline, Meireles, Martine, Persello, J, Schweins, R   +6 more
core   +6 more sources

Formulation, Characterization, and in Vivo Evaluation of Celecoxib-PVP Solid Dispersion Nanoparticles Using Supercritical Antisolvent Process

Molecules, 2014
The aim of this study was to develop celecoxib-polyvinylpyrrolidone (PVP) solid dispersion nanoparticles with and without surfactant using the supercritical antisolvent (SAS) process.
Eun-Sol Ha, Gwang-Ho Choo, In-Hwan Baek, Min-Soo Kim   +3 more
doaj   +1 more source

Preparation, optimization, and characterization of genistein-ginseng long-acting polymeric gel as a breast cancer treatment alternative

Discover Oncology
To address the prevalent genistein (GST) metabolism and inadequate intestinal absorption, an oral long-acting and gastric in-situ gelling gel was designed to encapsulate and localize the intestinal release of the loaded genistein-ginseng (GST-GNS) solid ...
Samaa Abdullah, Shadab Md, Abeer A. Altamimi, Hadil Alahdal, Raisuddin Ali, Huda Mohammed Alkreathy, Shahid Karim   +6 more
doaj   +1 more source