Results 1 to 10 of about 1,128,663 (346)

Heterocycles as a Peptidomimetic Scaffold: Solid-Phase Synthesis Strategies [PDF]

Pharmaceuticals, 2021
Peptidomimetics are a privileged class of pharmacophores that exhibit improved physicochemical and biological properties. Solid-phase synthesis is a powerful tool for gaining rapid access to libraries of molecules from small molecules to biopolymers and ...
Aizhan Abdildinova, Mark J. Kurth, Young-Dae Gong   +2 more
doaj   +2 more sources

Novel Solution- and Solid-Phase Strategies for the Parallel and Combinatorial Synthesis of Small-Molecular-Weight Compound Libraries

CHIMIA, 1996
In this account dedicated to '100 years Roche' in CHIMIA, we present some of our strategies towards the synthesis of interesting novel amino-acid-derived building blocks; multigeneration synthesis of thiazole libraries in solution; a novel solid-
Alexander Chucholowski, Thierry Masquelin, Daniel Obrecht, Josef Stadlwieser, José M. Villaigordo   +4 more
doaj   +5 more sources

Dielectrophoretic bead-droplet reactor for solid-phase synthesis [PDF]

Nature Communications
Solid-phase synthesis underpins many advances in synthetic and combinatorial chemistry, biology, and material science. The immobilization of a reacting species on the solid support makes interfacing of reagents an important challenge in this approach. In
Punnag Padhy, Mohammad Asif Zaman, Michael Anthony Jensen, Yao-Te Cheng, Yogi Huang, Mo Wu, Ludwig Galambos, Ronald Wayne Davis, Lambertus Hesselink   +8 more
doaj   +2 more sources

The Facile Solid-Phase Synthesis of Thiazolo-Pyrimidinone Derivatives [PDF]

Molecules
A thiazolo-pyrimidinone derivative library was developed through a facile solid-phase synthesis method. For the reaction, the thiazolo[4,5-d]pyrimidin-7(6H)-one structure was synthesized through efficient Thorpe–Ziegler and cyclization reactions.
Shuanghui Hua, Jimin Moon, Taeho Lee
doaj   +2 more sources

Laser solid-phase synthesis of single-atom catalysts [PDF]

Light: Science & Applications, 2021
Synthesis of Pt single atom catalysts is achieved by one-step laser irradiation of “isolated” H2PtCl6 precursor on graphene oxide, via filtration and freeze-drying sublimation, by simultaneous pyrolysis of the precursor and reduction of graphene oxide.
Yudong Peng, Jianyun Cao, Yang Sha, Wenji Yang, Lin Li, Zhu Liu   +5 more
doaj   +2 more sources

The interplay between thermodynamics and kinetics in the solid-state synthesis of layered oxides. [PDF]

, 2020
In the synthesis of inorganic materials, reactions often yield non-equilibrium kinetic byproducts instead of the thermodynamic equilibrium phase. Understanding the competition between thermodynamics and kinetics is a fundamental step towards the rational
Bai, Jianming, Bianchini, Matteo, Ceder, Gerbrand, Clément, Raphaële J, Kim, Haegyeom, Kitchaev, Daniil, Ouyang, Bin, Shi, Tan, Sun, Wenhao, Wang, Feng, Wang, Jingyang, Wang, Yan, Xiao, Penghao, Zhang, Mingjian, Zhang, Yaqian   +14 more
core   +1 more source

Efficient Syntheses of 1,2,3-Triazoloamide Derivatives Using Solid- and Solution-Phase Synthetic Approaches

Molecules, 2015
Efficient synthetic routes for the preparation of secondary and tertiary 1,2,3-triazoloamide derivatives were developed. A secondary α-1,2,3-triazoloamide library was constructed and expanded by a previously developed solid-phase synthetic route and a ...
Doohyun Lee, Daehun Kim, Seungyeon Lee, Taegeum Kim, Joobin Kim, Sohee Kim, Kwang-Hyeon Liu, Sangkyu Lee, Jong-Sup Bae, Kyung-Sik Song, Chang-Woo Cho, Youn Kyung Son, Dong Jae Baek, Taeho Lee   +13 more
doaj   +1 more source

Real-time monitoring of solid-phase peptide synthesis using a variable bed flow reactor [PDF]

, 2019
On-resin aggregation and incomplete amide bond formation are major challenges for solid-phase peptide synthesis that are difficult to be monitored in real-time.
Guthrie, Duncan, Nuño, Manuel, Seeberger, Peter H., Sletten, Eric T.   +3 more
core   +2 more sources

Fragment synthesis of disulfide-containing peptides

MethodsX, 2020
A new strategy for solid phase peptide synthesis in the fragment synthesis based on the use of 2-Cl-trityl resin as carrier to obtain protected peptide-resin and Rink Amide Resin, HOBT/HBTU or PyBOP/DIPEA or HATU/DIPEA as the coupling method is described.
Yuxuan Dai, Na Yue, Wenlong Huang, Hai Qian   +3 more
doaj   +1 more source

First total synthesis of hoshinoamide A

Beilstein Journal of Organic Chemistry, 2021
Hoshinoamides A, B and C, linear lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata, with potent antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum.
Haipin Zhou, Zihan Rui, Yiming Yang, Shengtao Xu, Yutian Shao, Long Liu   +5 more
doaj   +1 more source