Results 71 to 80 of about 1,859,179 (392)

Solid-phase synthesis of duocarmycin analogues and the effect of C-terminal substitution on biological activity [PDF]

, 2015
YesThe duocarmycins are potent antitumour agents with potential in the development of antibody drug conjugates (ADCs) as well as being clinical candidates in their own right.
Adcock, C., Collingwood, S.P., Fox, K.R., Howell, L.A., Kingston, J., O'Connell, M.A., Pors, Klaus, Searcey, M., Sheldrake, Helen M., Stephenson, M.J.   +9 more
core   +2 more sources

DNA-Encoded Solid-Phase Synthesis: Encoding Language Design and Complex Oligomer Library Synthesis

ACS Combinatorial Science, 2015
The promise of exploiting combinatorial synthesis for small molecule discovery remains unfulfilled due primarily to the “structure elucidation problem”: the back-end mass spectrometric analysis that significantly restricts one-bead-one-compound (OBOC ...
Andrew B. MacConnell, Patrick J. McEnaney, Valerie Cavett, B. M. Paegel   +3 more
semanticscholar   +1 more source

Solid‐Phase Synthesis of Oligosaccharides

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Diederichsen, Ulf, Wagner, Thomas
openaire   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

SASRIN™ a Versatile Tool in Peptide Synthesis and Solid-Phase Organic Chemistry

CHIMIA, 1999
The synthesis of the 4-(3-methoxy-4-(hydroxymethyl)phenoxymethyl) derivative of polystyrene-co-divinylbenzene (SASRIN™), its derivatives and its application in solid-phase peptide synthesis will be briefly reviewed in this paper.
Monika Mergler, Jacques Gosteli, Peter Grogg, Rolf Nyfeler, Rudolf Tanner   +4 more
doaj  

Solid Phase Formylation of N-Terminus Peptides

Molecules, 2016
Formylation of amino groups is a critical reaction involved in several biological processes including post-translational modification of histones. The addition of a formyl group (CHO) to the N-terminal end of a peptide chain generates biologically active
Anna Lucia Tornesello, Marina Sanseverino, Franco Maria Buonaguro   +2 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Synthèse de molécules d'intérêt biologique. Contribution à la synthèse des bastadines [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2010
Synthesis of molecules of biological interest. Contribution to the synthesis of bastadins. The metabolites are a biochemical area whose interest is in constant progression.
Decamps, C., Hantson, AL., Niemirowski, L., Capiau, E., De Meyer, M.   +4 more
doaj  

From Polymer to Small Organic Molecules: A Tight Relationship between Radical Chemistry and Solid-Phase Organic Synthesis

Molecules, 2011
Since Gomberg’s discovery of radicals as chemical entities, the interest around them has increased through the years. Nowadays, radical chemistry is used in the synthesis of 75% of all polymers, inevitably establishing a close relationship with Solid ...
Danilo Mirizzi, Maurizio Pulici
doaj   +1 more source

A microfluidic oligonucleotide synthesizer [PDF]

, 2010
De novo gene and genome synthesis enables the design of any sequence without the requirement of a pre-existing template as in traditional genetic engineering methods.
Lee, Cheng-Chung, Quake, Stephen R., Snyder, Thomas M.   +2 more
core   +4 more sources