Results 11 to 20 of about 5,620 (124)

Molecular cloning and characterization of duck CD83 and its effect on H9N2 avian influenza virus replication [PDF]

Poultry Science
Cluster of Differentiation 83 (CD83) is a multifunctional regulatory molecule that has been identified in several mammals, birds, and fishes; however, no reports have described CD83 in ducks to date.
Huinan Li, Xiaojing Xin, Zhe Yin, Chao Dong, Feng Li, Yujing Liu, Xinru Kong, Liyue Wang, Juan Wang, Fei Yu, Shanshan Huo   +10 more
doaj   +2 more sources

Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4/MD-2 Complex on CD14⁺ Monocytes. [PDF]

J Immunol, 2017
AbstractThe transmembrane protein CD83, expressed on APCs, B cells, and T cells, can be expressed as a soluble form generated by alternative splice variants and/or by shedding. Soluble CD83 (sCD83) was shown to be involved in negatively regulating the immune response.
Horvatinovich JM, Grogan EW, Norris M, Steinkasserer A, Lemos H, Mellor AL, Tcherepanova IY, Nicolette CA, DeBenedette MA.   +8 more
europepmc   +5 more sources

Prevention and treatment of experimental autoimmune encephalomyelitis by soluble CD83. [PDF]

J Exp Med, 2004
CD83 is up-regulated on the surface of dendritic cells (DCs) during maturation and has been widely used as a marker for mature DCs. Recently, we reported the recombinant expression of the extracellular immunoglobulin domain of human CD83 (hCD83ext). Using this soluble form of CD83, allogeneic as well as specific cytotoxic T lymphocyte proliferation ...
Zinser E, Lechmann M, Golka A, Lutz MB, Steinkasserer A.   +4 more
europepmc   +4 more sources

Pregnancy-related factors induce immune tolerance through regulation of sCD83 release [PDF]

Frontiers in Immunology
A well-balanced maternal immune system is crucial to maintain fetal tolerance in case of infections during pregnancy. Immune adaptations include an increased secretion of soluble mediators to protect the semi-allogeneic fetus from excessive pro ...
Pauline Krupa, Hannah Wein, Lea Sophie Zemmrich, Marek Zygmunt, Damián Oscar Muzzio   +4 more
doaj   +2 more sources

Nsp1α of Porcine Reproductive and Respiratory Syndrome Virus Strain BB0907 Impairs the Function of Monocyte-Derived Dendritic Cells via the Release of Soluble CD83. [PDF]

J Virol, 2018
ABSTRACT Porcine reproductive and respiratory syndrome virus (PRRSV), a virulent pathogen of swine, suppresses the innate immune response and induces persistent infection. One mechanism used by viruses to evade the immune system is to cripple the antigen-processing machinery in monocyte-derived dendritic cells (MoDCs).
Chen X, Bai J, Liu X, Song Z, Zhang Q, Wang X, Jiang P.   +6 more
europepmc   +4 more sources

Alpha-toxin-elicited CX3CL1 release in Staphylococcus aureus pneumonia impairs bactericidal function of human monocytes [PDF]

mBio
Staphylococcus aureus is an important human pathogen causing severe invasive infections. Pathogenesis is attributed to a wide array of virulence factors, including several potent exotoxins such as the pore-forming α-toxin.
Srikanth Mairpady Shambat, Puran Chen, Rocky M. Barilla, Markus Huemer, Johanna Snäll, Amanda Welin, Taylor S. Cohen, Virginia Takahashi, Samuel B. Berry, Alejandro Gómez-Mejia, Tiziano A. Schweizer, Danen M. Cunoosamy, Sara Cajander, Magda Lourda, Volkan Özenci, Ewerton Marques Maggio, Reto A. Schüpbach, Kristoffer Strålin, Annelies S. Zinkernagel, Anna Norrby-Teglund, Mattias Svensson   +20 more
doaj   +2 more sources

Soluble CD83 ameliorates experimental colitis in mice [PDF]

Mucosal Immunology, 2014
The physiological balance between pro- and anti-inflammatory processes is dysregulated in inflammatory bowel diseases (IBD) as in Crohn's disease and ulcerative colitis. Conventional therapy uses anti-inflammatory and immunosuppressive corticosteroids to treat acute-phase symptoms.
J, Eckhardt, S, Kreiser, M, Döbbeler, C, Nicolette, M A, DeBenedette, I Y, Tcherepanova, C, Ostalecki, A J, Pommer, C, Becker, C, Günther, E, Zinser, T W, Mak, A, Steinkasserer, M, Lechmann   +13 more
openaire   +2 more sources

Staphylococcal Enterotoxin A Shapes Monocyte Transcription and Macrophage Polarization: Implications for Immune Responses in Infection and Inflammation. [PDF]

Eur J Immunol
Staphylococcal enterotoxin A (SEA) alters monocyte differentiation and function, while preserving T cell stimulatory capacity. SEA‐primed macrophages downregulate antigen‐presenting markers yet drive heightened T‐cell proliferation and IFN‐γ secretion.
Arasa C, Rahman Qazi K, Brodin D, Mata Forsberg M, Sverremark-Ekström E.   +4 more
europepmc   +2 more sources

Chimeric Antigen Receptor T-Cell Therapy: More Than an Anti-Cancer Drug. [PDF]

HLA
ABSTRACT Initially, chimeric antigen receptor (CAR) T‐cell therapy was developed to eliminate malignant B cells in haematological B‐cell malignancies by targeting CD19 and B‐cell maturation antigen. This approach achieved notable success, resulting in (malignant) B‐cell depletion and inducing clinical remission in cancer patients.
Schenk HCM, Gille I, Arana C, Rovira J, Palou E, Diekmann F, Roelen DL, Heemskerk MHM, Heidt S.   +8 more
europepmc   +2 more sources

Alternative Splicing Generates Putative Soluble CD83 Proteins That Inhibit T Cell Proliferation [PDF]

The Journal of Immunology, 2005
Abstract CD83 is expressed on mature dendritic cells and activated lymphocytes and has been implicated to play an important role during T cell development in the thymus. In contrast, not much is known about the function of CD83 in the periphery.
Diana, Dudziak, Falk, Nimmerjahn, Georg W, Bornkamm, Gerhard, Laux   +3 more
openaire   +2 more sources