Results 61 to 70 of about 5,620 (124)

Mucosal‐Associated Invariant T Cells: Origins, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 11, November 2025.
Mucosa‐associated invariant T (MAIT) cells are an evolutionarily conserved class of innate‐like T lymphocytes that rely on MR1 molecules to recognize microbial metabolites and play a central role in immune surveillance and inflammatory regulation.
Cheng Zhu, Qian Huai, Yishan Du, Xingyu Li, Fumin Zhang, Yongkang Zhang, Mengwei Wu, Ying Dai, Xiaolei Li, Hanren Dai, Hua Wang   +10 more
wiley   +1 more source

Dendritic Cells: Origin, Classification, Development, Biological Functions, and Therapeutic Potential

MedComm, Volume 6, Issue 11, November 2025.
This review systematically summarizes dendritic cells (DCs) originating from hematopoietic stem cells, their major subsets (cDC1s, cDC2s, pDCs, moDCs, LCs) and core functions (antigen capture/presentation, adaptive immunity activation, immune tolerance induction, and regulation of innate immune cells).
Fangfang Jin, Lingxiang Xie, Hongqi Zhang, Xiang Fan, Jiaxing Tian, Wei Liu, Yang Xiao, Xinrong Fan   +7 more
wiley   +1 more source

Monovalent glycoconjugates of sulforaphane prevent inflammation induced by lipopolysaccharide in human dendritic cells by inhibiting NF‐ĸB signalling pathway

British Journal of Pharmacology, Volume 182, Issue 21, Page 5157-5172, November 2025.
Background and Purpose Sulforaphane (SFN) has notable health benefits but faces challenges due to its poor solubility and delivery. This study investigates SFN‐glycoconjugates effects on lipopolysaccharide (LPS)‐induced inflammation in dendritic cells (DCs). With the aiming to enhance their therapeutic potential against inflammatory diseases.
Camila Leiva‐Castro, Ana Maria Múnera‐Rodríguez, Macarena Martínez‐Bailén, Ana Teresa Carmona, Soledad López‐Enríquez, Francisca Palomares   +5 more
wiley   +1 more source

Paradoxical Activation of Entheseal Myeloid Cells by JAK1 and Tyk2 Inhibitors via Interleukin‐10 Antagonism

Arthritis &Rheumatology, Volume 77, Issue 10, Page 1373-1386, October 2025.
Objective JAK inhibition (JAKi) is effective in seronegative spondyloarthropathy (SpA) spectrum disorders, but Tyk2 inhibition failed in SpA spectrum ulcerative colitis, and tofacitinib showed minimal benefit in Crohn disease, which highlights the complex role for JAK/STAT signaling in different inflammatory processes.
Sami Giryes, Chi Wong, Charlie Bridgewood, Mark Harland, Ala Altaie, Nicole McDermott, Kerem Abacar, Abhay Rao, Almas Khan, Tristan McMillan, Peter Loughenbury, Robert Dunsmuir, Vishal Borse, Tom Macleod, Dennis McGonagle   +14 more
wiley   +1 more source

Co-culture of apoptotic breast cancer cells with immature dendritic cells: a novel approach for DC-based vaccination in breast cancer

Brazilian Journal of Medical and Biological Research, 2012
A dendritic cell (DC)-based vaccine strategy could reduce the risk of recurrence and improve the survival of breast cancer patients. However, while therapy-induced apoptosis of hepatocellular and colorectal carcinoma cells can enhance maturation and ...
Jin Zheng, Qiang Liu, Jiandong Yang, Qinyou Ren, Wei Cao, Jingyue Yang, Zhaocai Yu, Fang Yu, Yanlan Wu, Hengjun Shi, Wenchao Liu   +10 more
doaj   +2 more sources

370 Soluble CD83 inhibits skin inflammation to chemical sensitizers [PDF]

Journal of Investigative Dermatology, 2016
P. Mihatsch, P. Boyd, L. Krzyzak, M. Lechmann, J. Nicolas, V. Mahler, A. Steinkasserer, M. Vocanson   +7 more
openaire   +1 more source

Differentiation and Assessment of Monocyte-Derived Dendritic Cells in the Presence of Endothelial Cells Conditioned Media and Maturation Factors

مجله دانشکده پزشکی اصفهان, 2012
Background: Dendritic cells (DCs) migrate from the periphery to the T cell zone of secondary lymphoid organs. Thus, activated DCs are specialized cells that obtain information from the periphery and transfer it to lymphoid organs.
Keykavos Gholami, Vahid Nejati, Nowruz Delirezh, Masoumeh Asadi, Meysam Ganjibakhsh   +4 more
doaj  

Soluble CD83: a proresolving mediator in inflammatory arthritis? [PDF]

Nature Reviews Rheumatology, 2019
openaire   +2 more sources

Pan-cancer single-cell transcriptomic analysis reveals CD83 as a hallmark of tumor-associated neutrophils with senescent and pro-tumor properties. [PDF]

Comput Struct Biotechnol J
Wang Y, Meng Y, Chen K, Li A, Yan J, Ding J, Yang B, Tang L, Ding B, Chen S, Chen S, Chen F, Chen T, Zhang Y, Zheng Q, Chen C, Feng S.   +16 more
europepmc   +1 more source

BCG cell wall skeleton augments the immunogenicity of dengue nanoparticle vaccines by promoting dendritic cell activation. [PDF]

PLoS One
Limthongkul J, Warit S, Sunintaboon P, Ubol S, Jearanaiwitayakul T.   +4 more
europepmc   +1 more source