Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndrome [PDF]
Cell Reports Medicine, 2021 Summary: Data suggest that interleukin (IL)-6 blockade could reduce mortality in severe COVID-19, yet IL-6 is only modestly elevated in most patients. Chen et al.
Luke Y.C. Chen +5 more
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Soluble Interleukin-6 Receptor Regulates Interleukin-6-Dependent Vascular Remodeling in Long-Distance Runners [PDF]
Frontiers in Physiology, 2021 Little is known about the effects of training load on exercise-induced plasma increase of interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) and their relationship with vascular remodeling.
Paulina Villar-Fincheira +15 more
doaj +4 more sources
Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling. [PDF]
Sci Rep, 2017 Soluble Interleukin-6 receptor (sIL-6R) mediated trans-signaling is an important pro-inflammatory stimulus associated with pathological conditions, such as arthritis, neurodegeneration and inflammatory bowel disease.
Arnold P +16 more
europepmc +4 more sources
Soluble interleukin‐6 receptor in young adults and its relationship with body composition and autonomic nervous system [PDF]
Physiological Reports, 2019 Background The immune system generates inflammatory responses through cytokines like Interleukin 6 (IL‐6) and the Tumor Necrosis Factor alpha (TNF α); these cytokines mediate cellular responses aided by the presence of soluble receptors such as: Soluble ...
Henry H. León‐Ariza +3 more
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Soluble interleukin-6 receptor in patients with JAK2V617F somatic mutation and myeloproliferative neoplasm [PDF]
EClinicalMedicine, 2020 Christoph Garbers, Stefan Rose-John
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Soluble Interleukin 6 Receptor Measurement [PDF]
Definitions, 2020 National Cancer Institute
semanticscholar +3 more sources
Serum level of soluble interleukin 6 receptor is a useful biomarker for identification of treatment‐resistant major depressive disorder [PDF]
Neuropsychopharmacology Reports, 2020 Aim A substantial proportion of major depressive disorder patients are treatment‐resistant to antidepressant therapy, who require augmentation drugs, or other treatments including electroconvulsive therapy or transcranial magnetic stimulation ...
Katsuhiko Yamasaki +2 more
doaj +2 more sources
Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. [PDF]
Proceedings of the National Academy of Sciences, 1993 It has been reported that soluble interleukin (IL)-6 receptor (sIL-6R) is detected in the serum of healthy individuals and its level is increased in patients with multiple myeloma and human immunodeficiency virus infection. Although several reports have suggested that sIL-6R potentiates IL-6 action, its physiological role remains unclear. In this study,
T, Tamura +9 more
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Increased Soluble Interleukin 6 Receptors in Fabry Disease
Journal of Clinical Medicine, 2023 Fabry disease (FD) is an X-linked lysosome storage disease that results in the accumulation of globotriaosylceramide (Gb3) throughout the body leading to irreversible target organ damage. As the role of secondary mediators (inflammatory molecules) and their mechanisms has not been fully elucidated, we focused on the interleukin (IL)-6 system in adult ...
Lenzini, Livia +11 more
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Increased levels of soluble interleukin-6 receptor and CCL3 in COPD sputum. [PDF]
Respir Res, 2014 BackgroundCOPD patients have increased numbers of macrophages and neutrophils in the lungs. Interleukin-6 (IL-6) trans-signaling via its soluble receptor sIL-6R, governs the influx of innate immune cells to inflammatory foci through regulation of the ...
Ravi AK +8 more
europepmc +2 more sources