Results 11 to 20 of about 134,028 (256)

BODY IRON STATUS INDICATORS AND INFLAMMATION INDICATORS DURING INFLAMMATORY BOWEL DISEASE THERAPY IN CHILDREN AND ADOLESCENTES [PDF]

Arquivos de Gastroenterologia, 2021
BACKGROUND: The treatment of patients with inflammatory bowel disease (IBD) consists of the induction and maintenance remission of the disease. Iron status indicators would be useful for the diagnosis of iron deficiency anemia, whereas the inflammation ...
Fernanda F CORRÊA, Vera L SDEPANIAN
doaj   +1 more source

Interleukin-6 receptor polymorphism is prevalent in HIV-negative Castleman Disease and is associated with increased soluble interleukin-6 receptor levels. [PDF]

PLoS ONE, 2013
Multicentric Castleman Disease is largely driven by increased signaling in the pathway for the plasma cell growth factor interleukin-6. We hypothesized that interleukin-6/interleukin-6 receptor/gp130 polymorphisms contribute to increased interleukin-6 ...
Katie Stone, Emily Woods, Susann M Szmania, Owen W Stephens, Tarun K Garg, Bart Barlogie, John D Shaughnessy, Brett Hall, Manjula Reddy, Antje Hoering, Emily Hansen, Frits van Rhee   +11 more
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Associations between serum estradiol and IL-6/sIL-6R/sgp130 complex in female patients with major depressive disorder

BMC Psychiatry, 2023
Background It has been hypothesized that the IL-6/sIL-6R/sgp130 complex, an inflammatory complex, plays a critical role in the pathogenesis of major depressive disorder (MDD).
Ting Sun, Qian Chen, Junchi Mei, Yan Li
doaj   +1 more source

Increased Soluble Interleukin 6 Receptors in Fabry Disease

Journal of Clinical Medicine, 2023
Fabry disease (FD) is an X-linked lysosome storage disease that results in the accumulation of globotriaosylceramide (Gb3) throughout the body leading to irreversible target organ damage. As the role of secondary mediators (inflammatory molecules) and their mechanisms has not been fully elucidated, we focused on the interleukin (IL)-6 system in adult ...
Lenzini, Livia, Iori, Elisabetta, Vettore, Monica, Gugelmo, Giorgia, Radu, Claudia, Padoan, Andrea, Carraro, Gianni, Simioni, Paolo, Calò, Lorenzo, Avogaro, Angelo, Rossi, Gian Paolo, Vitturi, Nicola   +11 more
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Effects of the Interleukin-6 Receptor Blocker Sarilumab on Metabolic Activity and Differentiation Capacity of Primary Human Osteoblasts

Pharmaceutics, 2022
Interleukin (IL-) 6 is a key factor in the inflammatory processes of rheumatoid arthritis. Several biologic agents target the IL-6 signaling pathway, including sarilumab, a monoclonal antibody that blocks the IL-6 receptor and inhibits IL-6-mediated cis-
Annett Klinder, Janine Waletzko-Hellwig, Marie-Luise Sellin, Anika Seyfarth-Sehlke, Markus Wolfien, Franziska Prehn, Rainer Bader, Anika Jonitz-Heincke   +7 more
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Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. [PDF]

Proceedings of the National Academy of Sciences, 1993
It has been reported that soluble interleukin (IL)-6 receptor (sIL-6R) is detected in the serum of healthy individuals and its level is increased in patients with multiple myeloma and human immunodeficiency virus infection. Although several reports have suggested that sIL-6R potentiates IL-6 action, its physiological role remains unclear. In this study,
T, Tamura, N, Udagawa, N, Takahashi, C, Miyaura, S, Tanaka, Y, Yamada, Y, Koishihara, Y, Ohsugi, K, Kumaki, T, Taga   +9 more
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A case of autoimmune enteropathy with CTLA4 haploinsufficiency [PDF]

Intestinal Research, 2022
Autoimmune enteropathy (AIE) is a rare disease, characterized by intractable diarrhea, villous atrophy of the small intestine, and the presence of circulating anti-enterocyte autoantibodies. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked
Haruka Miyazaki, Namiko Hoshi, Michitaka Kohashi, Eri Tokunaga, Yuna Ku, Haruka Takenaka, Makoto Ooi, Nobuyuki Yamamoto, Suguru Uemura, Noriyuki Nishimura, Kazumoto Iijima, Keisuke Jimbo, Tsubasa Okano, Akihiro Hoshino, Kohsuke Imai, Hirokazu Kanegane, Ichiro Kobayashi, Yuzo Kodama   +17 more
doaj   +1 more source

A Potential Role of IL-6/IL-6R in the Development and Management of Colon Cancer

Membranes, 2021
Colorectal cancer (CRC) is the third most frequent cancer worldwide and the second greatest cause of cancer deaths. About 75% of all CRCs are sporadic cancers and arise following somatic mutations, while about 10% are hereditary cancers caused by ...
Mimmo Turano, Francesca Cammarota, Francesca Duraturo, Paola Izzo, Marina De Rosa   +4 more
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Role of Soluble Interleukin-6 Receptor With Interleukin-6 in Human Hematopoiesis

Hematology, 1997
A complex of soluble interleukin-6 receptor (sIL-6R) and interleukin-6 has been shown to play some roles in human hematopoiesis. It activates gp130 signal to stimulate human erythroid, megakaryocytic and primitive hematopoietic progenitor cells, which express gp130 but not IL-6R, in the presence of c-Kit signal mediated by stem cell factor (SCF).
K, Tsuji, T, Nakahata
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Admixture Mapping of an Allele Affecting Interleukin 6 Soluble Receptor and Interleukin 6 Levels [PDF]

The American Journal of Human Genetics, 2007
Circulating levels of inflammatory markers can predict cardiovascular disease risk. To identify genes influencing the levels of these markers, we genotyped 1,343 single-nucleotide polymorphisms (SNPs) in 1,184 African Americans from the Health, Aging and Body Composition (Health ABC) Study. Using admixture mapping, we found a significant association of
Reich, David, Patterson, Nick, Ramesh, Vijaya, De Jager, Philip L., McDonald, Gavin J., Tandon, Arti, Choy, Edwin, Hu, Donglei, Tamraz, Bani, Pawlikowska, Ludmila, Wassel-Fyr, Christina, Huntsman, Scott, Waliszewska, Alicja, Rossin, Elizabeth, Li, Rongling, Garcia, Melissa, Reiner, Alexander, Ferrell, Robert, Cummings, Steve, Kwok, Pui-Yan, Harris, Tamara, Zmuda, Joseph M., Ziv, Elad   +22 more
openaire   +2 more sources