Results 21 to 30 of about 164 (63)

Distinct Localization of SNAP47 Protein in GABAergic and Glutamatergic Neurons in the Mouse and the Rat Hippocampus

Frontiers in Neuroanatomy, 2017
Synaptosomal-associated protein of 47 kDa (SNAP47) isoform is an atypical member of the SNAP family, which does not contribute directly to exocytosis and synaptic vesicle (SV) recycling. Initial characterization of SNAP47 revealed a widespread expression
Agnieszka Münster-Wandowski, Heike Heilmann, Felix Bolduan, Thorsten Trimbuch, Yuchio Yanagawa, Imre Vida, Imre Vida   +6 more
doaj   +1 more source

Complexin I is required for mammalian sperm acrosomal exocytosis

, 2007
Regulated exocytosis in many cells is controlled by the SNARE complex, whose core includes three proteins that promote membrane fusion. Complexins I and II are highly related cytosolic proteins that bind tightly to the assembled SNARE complex and ...
Reim, Kerstin, Heather R. Burkin, Miller, David J., Zhao, Longmei, David J. Miller, Shi, X., Burkin, Heather R., Longmei Zhao, Xudong Shi, Burkin, H.eather R., Burkin, H., Li, Lingjun, Kerstin Reim, Lingjun Li, Reim, K., Zhao, L., Shi, Xudong, Miller, D., Li, L.   +18 more
core   +1 more source

Assessment of Neurobehavioral Performance and Markers of Synaptic Vesicle Trafficking in an Alpha-Synuclein Knockout Mouse Model after Controlled Cortical Impact Injury

Neurotrauma Reports
Traumatic brain injury (TBI) is associated with significant deficits across cognitive, emotional, and somatic functions, contributing to reduced quality of life for TBI survivors. Synaptic vesicle cycling, crucial for neurotransmitter release, involves a
Eleni H. Moschonas, Zachary Rohde, Madison Parry, Japna Bhatia, Scott Fellman, Elyse C. Pullen, Ananya R. Shah, Jeremy Henchir, Youming Li, C. Edward Dixon, Shaun W. Carlson   +10 more
doaj   +1 more source

Presynaptic mechanisms determining the dynamic range of neurotransmitter release in the lateral amygdala [PDF]

, 2008
The amygdala is a central brain structure receiving sensory information from diverse regions of the central nervous system. Cortical and thalamic axons converge to the lateral amygdala (LA) which is thought to be the main site for fear-induced ...
Fourcaudot, Elodie
core   +1 more source

State-Dependent Bidirectional Modification of Somatic Inhibition in Neocortical Pyramidal Cells

, 2008
SummaryCortical pyramidal neurons alter their responses to input signals depending on behavioral state. We investigated whether changes in somatic inhibition contribute to these alterations.
Kurotani, Tohru, Yoshimura, Yumiko, Crair, Michael C., Yamada, Kazumasa, Komatsu, Yukio   +4 more
core   +1 more source

Effect of amyloids on the vesicular machinery: Implications for somatic neurotransmission

, 2015
Certain neurodegenerative diseases are thought to be initiated by the aggregation of amyloidogenic proteins. However, the mechanism underlying toxicity remains obscure.
Maiti, Sudipta, Das, Anand Kant, Pandit, Rucha   +2 more
core   +1 more source

The proteostatic landscape of healthy human oocytes

The EMBO Journal
Oocytes, female germ cells that develop into eggs, are among the longest-lived cells in the animal body. Recent studies on mouse oocytes highlight unique adaptations in protein homeostasis (proteostasis) within these cells.
Gabriele Zaffagnini, Miquel Solé, Juan Manuel Duran, Nikolaos P Polyzos, Elvan Böke   +4 more
doaj   +1 more source

Molecular anatomy and physiology of exocytosis in sensory hair cells

, 2012
Hair cells mediate our senses of hearing and balance by synaptic release of glutamate from somatic active zones (AZs). They share conserved mechanisms of exocytosis with neurons and other secretory cells of diverse form and function. Concurrently. AZs of
Pangrsic, Tina, Rutherford, Mark A.
core   +1 more source

Synaptic GABA release prevents GABA transporter type-1 reversal during excessive network activity.

, 2015
GABA transporters control extracellular GABA, which regulates the key aspects of neuronal and network behaviour. A prevailing view is that modest neuronal depolarization results in GABA transporter type-1 (GAT-1) reversal causing non-vesicular GABA ...
Rusakov, Dmitri A., Walker, MC, Savtchenko, L, Pavlov, I, Megalogeni, M, Walker, Matthew C., Rusakov, DA, Savtchenko, Leonid, Pavlov, Ivan, Megalogeni, Maria   +9 more
core   +1 more source

Determining the neurotransmitter concentration profile at active synapses [PDF]

, 2009
Establishing the temporal and concentration profiles of neurotransmitters during synaptic release is an essential step towards understanding the basic properties of inter-neuronal communication in the central nervous system.
Beato, M., Marco Beato, Annalisa Scimemi, Scimemi, A.   +3 more
core   +1 more source