Results 11 to 20 of about 1,246 (117)

Insulin-Like Growth Factors, Binding Proteins and Their Role in Pregnancy in Patients With Diabetes. [PDF]

J Diabetes Res
The insulin‐like growth factor (IGF) axis, an evolutionarily conserved system, is critical in regulating cell growth, proliferation, and survival, affecting nearly all organ systems. This axis comprises two growth factors, IGF‐I and IGF‐II, and six insulin‐like growth factor–binding proteins (IGFBPs), modulating IGF activity.
Gladych-Macioszek A, Ozegowska K, Radzicka-Mularczyk S, Sibiak R, Desoye G, Wender-Ozegowska E.   +5 more
europepmc   +2 more sources

Delayed Bone Maturation and Extended Growth Phase as Distinctive Features of 17α-Hydroxylase/17,20-Lyase Deficiency: A Retro-Prospective Study of a Large Patient Cohort. [PDF]

Clin Endocrinol (Oxf)
ABSTRACT Introduction Worldwide, combined 17‐hydroxylase/17,20‐lyase deficiency (CYP17D) is a rare form of congenital adrenal hyperplasia, but it is the second most prevalent type in Brazil. An absence of sexual differentiation and hypergonadotropic hypogonadism arise from a reduction in the usual pattern of sex steroid formation in the adrenals and ...
Fontenele R, Costa-Barbosa FA, Costa-Santos M, Batista RL, Mermejo LM, Mendonça BB, de Castro M, Guerra-Júnior G, Kater CE, Brazilian Congenital Adrenal Hyperplasia Multicenter Study Group (BCAHMSG).   +9 more
europepmc   +2 more sources

Intact pulse cotyledon cell diet improves systemic growth via the somatotropic axis in malnourished mice

iMetaOmics, Volume 3, Issue 1, March 2026.
The MAL‐IC diet promotes growth in malnourished mice by regulating the gut microbiota—increasing the abundance of carbohydrate‐utilizing bacteria and SCFAs production. SCFAs circulate to the liver via the gut–liver axis, where they bind FFAR2 and activate the somatotropic axis, thereby stimulating GHR‐mediated GH signaling and increasing IGF‐1 and ...
Yumeng Yan, Zhuqing Xie, Zhipeng Gu, Zhongxin Li, Qiang Huang, Bin Zhang   +5 more
wiley   +1 more source

SUSD2 Promotes Metastasis and Primary Tumor Growth in Pancreatic Cancer Cells via Integrin–FAK Signaling Activation

Cancer Science, Volume 117, Issue 3, Page 711-726, March 2026.
This study investigates the role of Sushi domain‐containing 2 (SUSD2) in pancreatic ductal adenocarcinoma (PDAC) and demonstrates that SUSD2 enhances both metastasis and primary tumor growth by promoting integrin β1–FAK signaling. SUSD2 interacts with integrin β1, enhancing adhesion to extracellular matrix (ECM) components such as collagen 1 and ...
Junjiro Yoshida, Tomokazu Ohishi, Isao Momose, Shun‐ichi Ohba, Kyohei Kurosawa, Akiko Harakawa, Hiroyuki Inoue, Minori Senoo, Daisuke Tatsuda, Hikaru Abe, Atsushi Masamune, Manabu Kawada   +11 more
wiley   +1 more source

Structural basis for uPAR binding to an antibody developed for targeted cancer therapy. Mechanistic insights into flexibility, ligand recognition, and molecular imaging

Protein Science, Volume 35, Issue 2, February 2026.
Abstract The urokinase‐type plasminogen activator receptor (uPAR) is currently gaining momentum as a promising molecular target for treatment of various solid cancers. For patient stratification, we developed a high‐affinity uPAR‐targeting peptide (AE105) detecting primary cancer lesions as well as occult metastasis by positron emission tomography (PET)
Rex F. Anane, Anni Kumari, Hari Venugopal, Sylvain Trépout, James C. Whisstock, Lars H. Engelholm, Ruby H. P. Law, Michael Ploug   +7 more
wiley   +1 more source

Differences in the Expression of Insulin‐Like Growth Factor Signaling Pathway Members in Patients With Psoriasis Vulgaris and Controls

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Insulin‐like growth factors (IGFs) and IGF–binding proteins (IGFBPs) regulate cell proliferation, differentiation, metabolic processes, and immune activities. Psoriasis is a systemic inflammatory disease with metabolic disorders as an important comorbidity in the pathogenesis of which members of the IGF family could also play a role.
Holmannova Drahomira, Borska Lenka, Fiala Zdenek, Krejsek Jan, Hamakova Kvetoslava, Cermakova Eva, Rehacek Vit, Fiala Ondrej, Maresova Tereza, Borsky Pavel, Jasbir Arora (RSS)   +10 more
wiley   +1 more source

Massive reduction of RyR1 in muscle spindles of mice carrying recessive Ryr1 mutations alters proprioception and causes scoliosis

The Journal of Physiology, Volume 603, Issue 22, Page 6949-6977, November 15, 2025.
Abstract figure legend Intrafusal muscles contained within muscle spindles are endowed with ryanodie receptor 1 (RyR1) calcium channels and participate in proprioceptor function. Mutations in RyR1 linked to severe RYR1‐congenital myopathies affect calcium release from both extrafusal as well as intrafusal muscles.
Alexis Ruiz, Sofia Benucci, Hervé Meier, Georg Schultz, Katarzyna Buczak, Christoph Handschin, Rodrigo C. G. Pena, Susan Treves, Francesco Zorzato   +8 more
wiley   +1 more source

A high‐resolution data set of fatty acid‐binding protein structures. III. Unexpectedly high occurrence of wrong ligands

Acta Crystallographica Section D, Volume 81, Issue 8, Page 451-464, August 2025.
Very high‐resolution fatty acid‐binding protein structures identified a substantial number of ligands that differ strongly from their expected structure. If different ligand chemistry is a potentially overlooked problem in other, lower resolution, crystal structures of protein–ligand complexes, it has repercussions for any study using such structures ...
Andreas Ehler, Christian Bartelmus, Joerg Benz, Inken Plitzko, Markus G. Rudolph   +4 more
wiley   +1 more source

2‐Octyl cyanoacrylate adjuvant use in calcaneal tendon repair: A comparative experimental study in rabbits

Journal of Experimental Orthopaedics, Volume 12, Issue 2, April 2025.
Abstract Purpose The treatment of Achilles tendon (AT) rupture can be conservative or surgical; the latter is better indicated in high‐performance athletes. The pursuit of faster recovery and reductions in skin complications and re‐ruptures have improved the tendon repair technique and early assisted rehabilitation programs.
Rogério de Andrade Gomes, Marco Antônio Percope de Andrade, Luiz Eduardo Moreira Teixeira, Bruno Jannotti Pádua, Sidney Max E. Silva, Matheus Maciel Vilela, Paulo Feliciano Sarquis Dias, Eduardo Paulino Júnior, Ivana Duval de Araújo   +8 more
wiley   +1 more source

Probiotics and Spirulina platensis Improved Growth Performance of Nile Tilapia (Oreochromis niloticus) by Upgrading Intestinal Morphology and Activating GH/IGF Axis

Aquaculture Research, Volume 2025, Issue 1, 2025.
Probiotics and spirulina are used to improve health, growth, and immunity of fish. The purpose of this study was to evaluate the effects of water additive probiotics and dietary Spirulina platensis on growth (weight gain (WG) and specific growth rate (SGR)), hematobiochemical parameters (hemoglobin (Hb) and blood glucose (Glu)), intestinal histology ...
Muallimul Islam, Haphsa Khanom, Naimul Islam, Fouzia Fariha, Bilal Ahamad Paray, Md Mahiuddin Zahangir, Md Shahjahan   +6 more
wiley   +1 more source