Results 21 to 30 of about 3,099 (165)

Proteomic exploration of potential blood biomarkers in haemophilic arthropathy

Health Science Reports, Volume 7, Issue 9, September 2024.
Abstract Background and Aims The pathophysiology of haemophilic arthropathy (HA) is complex and largely undefined. Proteomic analyses provide insights into the intricate mechanisms of the HA. Our study aimed to identify differentially expressed proteins in relation to the severity of HA, explore their pathophysiological roles, and evaluate their ...
Nataša Kalebota, Ruđer Novak, Stela Hrkač, Porin Perić, Grgur Salai, Marko Močibob, Marija Pranjić, Zbyněk Zdráhal, Václav Pustka, Nadica Laktašić Žerjavić, Milan Milošević, Marijo Vodanović, Silva Zupančić Šalek, Lovorka Grgurević   +13 more
wiley   +1 more source

Early life interventions metformin and trodusquemine metabolically reprogram the developing mouse liver through transcriptomic alterations

Aging Cell, Volume 23, Issue 9, September 2024.
This study examined the effects of metformin (MF) and trodusquemine (MSI‐1436) on the livers of young, developing mice. We discovered that MSI‐1436 significantly alters mRNA and miRNA expression more potently than MF, impacting key metabolic pathways.
Sarah A. Ashiqueali, Augusto Schneider, Xiang Zhu, Ewelina Juszczyk, Mishfak A. M. Mansoor, Yun Zhu, Yimin Fang, Bianka M. Zanini, Driele N. Garcia, Natalie Hayslip, David Medina, Samuel McFadden, Robert Stockwell, Rong Yuan, Andrzej Bartke, Michael Zasloff, Shadab Siddiqi, Michal M. Masternak   +17 more
wiley   +1 more source

Scale‐Dependent Rheology of Synovial Fluid Lubricating Macromolecules

Small, Volume 20, Issue 21, May 23, 2024.
A multiscale methodology using optical tweezers is developed to examine the interactions between hyaluronic acid (HA) and proteoglycan‐4 (PRG4/lubricin), which are major lubricating biomolecules of synovial fluid in the joints. For the first time, the length scale dependent structure and rheology in solution are characterized, providing a framework for
Leonardo Martin‐Alarcon, Aleksandra Govedarica, Randy H. Ewoldt, Steven L. Bryant, Gregory D. Jay, Tannin A. Schmidt, Milana Trifkovic   +6 more
wiley   +1 more source

Proteoglycan 4 (PRG4) treatment improves skin wound healing in a porcine model

The FASEB Journal, Volume 38, Issue 6, 31 March 2024.
Proteoglycan 4 (PRG4) is commonly found in synovial fluid of the articular joint and serves as a boundary lubricant of articular cartilage. Interestingly, we show that human recombinant proteoglycan 4 (rhPRG4) improves healing of porcine full‐thickness skin injuries. rhPRG4 treatment decreases fibrosis, increases vascularization, and retains adipocytes
Nicoletta Ninkovic, Holly D. Sparks, Dragana Ponjevic, Greg Muench, Jeff A. Biernaskie, Roman J. Krawetz   +5 more
wiley   +1 more source

Advances in the Use of Biologics and Biomaterials toward the Improvement of Pancreatic Islet Graft Survival in Type 1 Diabetes

Advanced NanoBiomed Research, Volume 4, Issue 3, March 2024.
Although islet transplantation has the potential to serve as a curative treatment for type 1 diabetes, there are many hurdles to achieving long‐term islet graft survival. This review discusses the recent advances in strategies to improve islet survival function using exogenous compounds and conformal coatings as a promising tool for improving islet ...
Michael Yilma Yitayew, Marina Luginina, Maryam Tabrizian   +2 more
wiley   +1 more source

The biophysical and compositional properties of human basement membranes

The FEBS Journal, Volume 291, Issue 3, Page 477-488, February 2024.
Basement membranes are exceptionally adaptable materials with both extremely stiff and highly elastic properties. This article highlights these features on a selection of human membranes and links them to compositional, biomechanical, and structural profiles down to a molecular level. The role of water in modulating these attributes is also scrutinized
Monica S. Schoenenberger, Willi Halfter, Alexia Ferrand, Kathrin Halfter, Alexandar Tzankov, Hendrik P. N. Scholl, Paul Bernhard Henrich, Christophe A. Monnier   +7 more
wiley   +1 more source

Quantification of insulin‐like growth factor‐I by liquid chromatography–mass spectrometry

Rapid Communications in Mass Spectrometry, Volume 38, Issue S1, January 2024.
We describe three methods of sample preparation for the liquid chromatography coupled with mass spectrometric measurement of insulin‐like growth factor‐I concentration in blood. One method involves trypsin digestion, the second involves intact protein quantification and the third method is a combination of the first two.
Danielle A. Moncrieffe, David A. Cowan
wiley   +1 more source

Molecular crosstalk between insulin‐like growth factors and follicle‐stimulating hormone in the regulation of granulosa cell function

Reproductive Medicine and Biology, Volume 23, Issue 1, January/December 2024.
Crosstalk between insulin‐like growth factors and follicle‐stimulating hormone in the regulation of ovarian antral follicles. Abstract Background The last phase of folliculogenesis is driven by follicle‐stimulating hormone (FSH) and locally produced insulin‐like growth factors (IGFs), both essential for forming preovulatory follicles.
Emily Hayes, Nicola Winston, Carlos Stocco   +2 more
wiley   +1 more source

Mitigation of Diabetes Mellitus Using Euphorbia helioscopia Leaf Ethanolic Extract by Modulating GCK, GLUT4, IGF, and G6P Expressions in Streptozotocin‐Induced Diabetic Rats

Journal of Diabetes Research, Volume 2024, Issue 1, 2024.
Diabetes mellitus is a metabolic disorder. Synthetic antidiabetics are the commonly used treatment options associated with complications. The objective of this study was to explore the antioxidative and antidiabetic potential of Euphorbia helioscopia whole plant ethanolic extract using in vitro and in vivo models.
Ahmed Raza, Muhammad Naveed Mushtaq, Sadia Hassan, Ali Sharif, Bushra Akhtar, Muhammad Furqan Akhtar, Driss Ousaaid   +6 more
wiley   +1 more source

Somatolactogens, Somatomedins, and Immunity

Journal of Dairy Science, 1993
The neuroendocrine and immune systems participate as active partners in host homeostatic and defense mechanisms. This partnership involves a complex intercommunication system employing an array of shared ligands and receptors. Hormones of the somatolactogen family have marked influences on immune events in vivo, including the maintenance of lymphoid ...
S, Arkins, R, Dantzer, K W, Kelley
openaire   +2 more sources