Results 161 to 170 of about 128,394 (306)

Pancreatic Neuroendocrine Tumor Leading to a Diagnosis of Multiple Endocrine Neoplasia Type 1

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Pancreatic neuroendocrine neoplasms are rare but occasionally encountered. They are generally highly vascularized solid tumors, often round in shape with clear boundaries, defined contours, and a homogeneous internal structure. However, they can also present with atypical features, such as cystic degeneration, hemorrhage, calcification, and ...
Noriyuki Hirakawa, Katsuya Kitamura, Kei Yamamoto, Kenichi Tadokoro, Yasunosuke Akita, Jun Uemura, Fumito Yamanishi, Masakazu Abe, Munehide Nakatsugawa, Takao Itoi   +9 more
wiley   +1 more source

Optic Nerve Sheath Meningiomas in Children: Diagnostic Challenges Based on a Case Series

Pediatric Blood &Cancer, Volume 72, Issue 7, July 2025.
ABSTRACT The diagnosis of optic nerve sheath meningiomas (ONSM) in children and teenagers remains challenging despite advances in high‐quality imaging. We identified seven children diagnosed with ONSM in four tertiary paediatric oncology centres in the United Kingdom.
Deysha Ratnasingham, George Lawson, Harpreet Hyare, Sam Gurney, John Apps, Ian Reekie, Sucheta Vaidya, Carmen Soto, Kavitha Srivatsa, Jaroslaw Peregud‐Pogorzelski, Andrzej Brodkiewicz, Owase Jeelani, Mette Jorgensen, Sarita Depani, Darren Hargrave, Elwira Szychot   +15 more
wiley   +1 more source

The dark sides of the GPCR tree ‐ research progress on understudied GPCRs

British Journal of Pharmacology, Volume 182, Issue 14, Page 3109-3134, July 2025.
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf, Laura J. Humphrys, Sandra Berndt, Antonella Di Pizio, Juliane Lehmann, Ines Liebscher, Alessandro Nicoli, Masha Y. Niv, Lior Peri, Hannes Schihada, Gunnar Schulte   +10 more
wiley   +1 more source

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, Volume 182, Issue 14, Page 3249-3300, July 2025.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

EFFECTS OF SOMATOSTATIN ON GASTRIC ACID SECRETION AND ON LIPID AND CARBOHYDRATE METABOLISM IN THE RAT [PDF]

, 1978
Willem G. Linscheer, Krishan L. Raheja
openalex   +1 more source

The path to the G protein‐coupled receptor structural landscape: Major milestones and future directions

British Journal of Pharmacology, Volume 182, Issue 14, Page 3225-3248, July 2025.
G protein‐coupled receptors (GPCRs) play a crucial role in cell function by transducing signals from the extracellular environment to the inside of the cell. They mediate the effects of various stimuli, including hormones, neurotransmitters, ions, photons, food tastants and odorants, and are renowned drug targets.
Małgorzata M. Kogut‐Günthel, Zeenat Zara, Alessandro Nicoli, Alexandra Steuer, Marta Lopez‐Balastegui, Jana Selent, Sanjai Karanth, Melanie Koehler, Antonella Ciancetta, Layara Akemi Abiko, Franz Hagn, Antonella Di Pizio   +11 more
wiley   +1 more source

The Mediators of Bile Action on the Exocrine Pancreas [PDF]

, 1993
Baba N, Beauchamp R D, Björnsson O G, Bondesen S, Burhol P G, Burhol P G, Burhol P G, Burhol P G, Chayvialle J A, Chey W Y, Davies H A, Domschke S, Fahrenkrug J, Feurle G E, Fiedler F, Fiedler F, Flaten O, Forell M M, Forell M M, Fölsch U R, Gomez G, Gomez G, Gomez G, Gomez G, Greeley G H, Grundy S M, Hanssen L E, Hanssen L E, Hanssen L E, Hoist J J, Hoist J J, Hoist J J, Häcki W H, Imamura M, Imamura M, Khalil T, Konturek S J, Koop I, Koop I, Koop I, Koop I, Koop I, Koop I, Koop I, Larsson L I, Layer P, Lehnert P, Londong W, Londong W, Lonovics J, Malagelada J R, Mellanby J, Miyasaka K, Nakaba H, Nakamura R, Nakamura R, Nustede R, Ohta H, Osnes M, Osnes M, Osnes M, P. Lehnert, Petersen H, R. L. Riepl, Rhodes J, Riepl R L, Riepl R L, Riepl R L, Sakamoto T, Schaffalitzky de Muckadell O B, Schwartz T W, Shiratori K, Singer M V, Singer M V, Singer M V, Solomon T E, Tsuchiya T   +76 more
core   +1 more source

Ketotic Hypoglycaemia Following Sleeve Gastrectomy

Clinical Endocrinology, Volume 103, Issue 1, Page 45-49, July 2025.
ABSTRACT Post‐bariatric surgery hypoglycaemia is typically mediated by hyperinsulinaemia, although the exact mechanisms are incompletely understood. Two cases of non‐insulin mediated, ketotic hypoglycaemia following sleeve gastrectomy are presented. After fasting for 40 and 65 h, respectively, both patients developed symptomatic hypoglycaemia, with ...
Jinwen He, Liza Phillips, Janelle Nisbet, Adam Morton   +3 more
wiley   +1 more source

EFFECTS OF SOMATOSTATIN ON PLASMA INSULIN, GROWTH HORMONE AND GLUCAGON LEVELS IN OBESE AND DIABETIC CHILDREN AND ADOLESCENTS [PDF]

, 1975
L Gargantini, G Chiumello
openalex   +1 more source

Hypersomatotropism and Hypercortisolism Caused by a Plurihormonal Pituitary Adenoma in a Dog

Journal of Veterinary Internal Medicine, Volume 39, Issue 4, July/August 2025.
ABSTRACT A 12‐year‐old, male Labrador Retriever was presented because of polyuria, polydipsia, polyphagia, joint pain, and physical features consistent with acromegaly. Circulating insulin‐like growth factor‐1 (IGF‐1) concentration was increased (> 1000 ng/mL; reference interval [RI], 42–449), suggestive of hypersomatotropism.
Elber A. Soler Arias, Ricardo Rodas Elvir, Adrian F. Daly, Hans S. Kooistra   +3 more
wiley   +1 more source