BMC Infectious Diseases, 2005 Background The neuropeptide somatostatin is one of the major regulatory peptides in the central nervous system and the digestive tract. Our recent work has delineated an association between fibrosis and low levels of endogenous somatostatin plasma levels
Peeters Theo +4 more
doaj +1 more source
Forum of Clinical Oncology, 2023 Liposarcomas are malignant mesenchymal neoplasms that, although derived from adipocytes, may dedifferentiate to other cell types. We present an exceedingly rare case of epithelioid/neuroendocrine dedifferentiation with somatostatin expression of a ...
Gaggero Gabriele +4 more
doaj +1 more source
Dedicated hippocampal inhibitory networks for locomotion and immobility [PDF]
, 2017 Network activity is strongly tied to animal movement; however, hippocampal circuits selectively engaged during locomotion or immobility remain poorly characterized.
Arriaga, Moises, Han, Edward B
core +2 more sources
Design Principles of Pancreatic Islets: Glucose-dependent Coordination of Hormone Pulses [PDF]
, 2015 Pancreatic islets are functional units involved in glucose homeostasis. The multicellular system comprises three main cell types; $\beta$ and $\alpha$ cells reciprocally decrease and increase blood glucose by producing insulin and glucagon pulses, while ...
Hara, Manami +2 more
core +6 more sources
Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?
Frontiers in Pharmacology, 2013 Our knowledge of the pathophysiology of affect dysregulation has progressively increased, but the pharmacological treatments remain inadequate. Here, we summarize the current literature on deficits in somatostatin, an inhibitory modulatory neuropeptide ...
Li-Chun eLin, Etienne eSibille
doaj +1 more source
Growth Hormone (GH)-Releasing Peptide Stimulation of GH Release from Human Somatotroph Adenoma Cells: Interaction with GH-Releasing Hormone, Thyrotropin- Releasing Hormone, and Octreotide. [PDF]
, 1994 The synthetic hexapeptide GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) specifically stimulates GH secretion in humans in vivo and in animals in vitro and in vivo via a still unknown receptor and mechanism.
Brockmeier, S. +7 more
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Frontiers in Aging Neuroscience, 2021 Changes in the physiology, neurochemistry and structure of neurons, particularly of their dendritic spines, are thought to be crucial players in age-related cognitive decline. One of the most studied brain structures affected by aging is the hippocampus,
Yaiza Gramuntell +9 more
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Cellular mechanisms underlying central sensitization in a mouse model of chronic muscle pain
eLife, 2022 Chronic pain disorders are often associated with negative emotions, including anxiety and depression. The central nucleus of the amygdala (CeA) has emerged as an integrative hub for nociceptive and affective components during central pain development ...
Yu-Ling Lin +8 more
doaj +1 more source
Effect of Intraduodenal Bile and Taurodeoxycholate on Exocrine Pancreatic Secretion and on Plasma Levels of Vasoactive Intestinal Polypeptide and Somatostatin in Man [PDF]
, 1994 Intraduodenal (i.d.) application of bile or Na-taurodeoxycholate (TDC) dose dependently enhances basal exocrine pancreatic secretion. The hydrokinetic effect is mediated at least in part by secretin.
Fiedler, Fritz +3 more
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Somatostatin Analogues in the Treatment of Neuroendocrine Tumors: Past, Present and Future [PDF]
, 2019 In recent decades, the incidence of neuroendocrine tumors (NETs) has steadily increased. Due to the slow-growing nature of these tumors and the lack of early symptoms, most cases are diagnosed at advanced stages, when curative treatment options are no ...
Amthauer, Holger +8 more
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