Results 11 to 20 of about 115,117 (314)
Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?
Frontiers in Pharmacology, 2013 Our knowledge of the pathophysiology of affect dysregulation has progressively increased, but the pharmacological treatments remain inadequate. Here, we summarize the current literature on deficits in somatostatin, an inhibitory modulatory neuropeptide ...
Li-Chun eLin, Etienne eSibille
doaj +2 more sources
Somatostatin Analogs in Clinical Practice: A Review
International Journal of Molecular Sciences, 2020 Somatostatin analogs are an invaluable therapeutic option in the diagnosis and treatment of somatotropinomas, thyrotropinomas, and functioning and non-functioning gastroenteropancreatic neuroendocrine tumors.
Mariana Gomes-Porras +2 more
semanticscholar +1 more source
Epilepsia Open, EarlyView., 2022 Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica +6 more
wiley +1 more source
Somatostatin and somatostatin receptors in retinal diseases [PDF]
European Journal of Endocrinology, 2000 Somatostatin is a small neuropeptide that is producedin the central nervous system, where it acts as aneurotransmitter. This neuropeptide also has animportant role in the neuroendocrine system as aninhibitor of hormone release, the most strikingexample of which is the inhibition of growth hormonerelease.
van, Hagen PM +7 more
openaire +5 more sources
Overview of Radiolabeled Somatostatin Analogs for Cancer Imaging and Therapy
Molecules, 2020 Identified in 1973, somatostatin (SST) is a cyclic hormone peptide with a short biological half-life. Somatostatin receptors (SSTRs) are widely expressed in the whole body, with five subtypes described. The interaction between SST and its receptors leads
Romain Eychenne +5 more
semanticscholar +1 more source
Regulatory Mechanisms of Somatostatin Expression
International Journal of Molecular Sciences, 2020 Somatostatin is a peptide hormone, which most commonly is produced by endocrine cells and the central nervous system. In mammals, somatostatin originates from pre-prosomatostatin and is processed to a shorter form, i.e., somatostatin-14, and a longer ...
Emmanuel Ampofo +3 more
semanticscholar +1 more source
Somatostatin receptor expression in parathyroid neoplasms
Endocrine Connections, 2019 Introduction: Parathyroid carcinoma represents a rare cause of primary hyperparathyroidism. Distinguishing carcinoma from the benign tumors underlying primary hyperparathyroidism remains challenging.
Sara Storvall +6 more
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Nature Communications, 2019 The formation and maintenance of spatial representations within hippocampal cell assemblies is strongly dictated by patterns of inhibition from diverse interneuron populations.
Matt Udakis +4 more
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Frontiers in Oncology, 2022 Neuroendocrine neoplasms (NENs) comprise a heterogeneous collection of tumors derived from various neuroendocrine cells and are divided into functioning NEN and non-functioning NEN. Some NENs present with mild symptoms and can secrete somatostatin. These
Yuming Shao +5 more
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Molecular and functional characterization of somatostatin-type signalling in a deuterostome invertebrate [PDF]
Open Biology, 2020 Somatostatin (SS) and allatostatin-C (ASTC) are structurally and evolutionarily related neuropeptides that act as inhibitory regulators of physiological processes in mammals and insects, respectively.
Ya Zhang +5 more
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