Results 11 to 20 of about 76,426 (249)
Frontiers in Molecular Neuroscience, 2022 Cortical neuron loss is a pathological hallmark of late-onset Alzheimer’s disease (AD). However, it remains unclear which neuronal subtypes beyond broad excitatory and inhibitory classes are most vulnerable.
Micaela E. Consens +16 more
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Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?
Frontiers in Pharmacology, 2013 Our knowledge of the pathophysiology of affect dysregulation has progressively increased, but the pharmacological treatments remain inadequate. Here, we summarize the current literature on deficits in somatostatin, an inhibitory modulatory neuropeptide ...
Li-Chun eLin, Etienne eSibille
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Pharmaceutical Biology, 2023 Context Bombax ceiba Linnaeus (Bombacaceae) is known as silk cotton tree, the flowers of which are used in many medicinal applications.Objective To investigate the therapeutic effect of B.
Liuping Wang +6 more
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Approach of Acromegaly during Pregnancy
Diagnostics, 2022 Acromegaly-related sub/infertility, tidily related to suboptimal disease control (1/2 of cases), correlates with hyperprolactinemia (1/3 of patients), hypogonadotropic hypogonadism—mostly affecting the pituitary axis in hypopituitarism (10–80%), and ...
Alexandru Dan Popescu +7 more
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PET Imaging of Perceptual Learning-Induced Changes in the Aged Rodent Cholinergic System
Frontiers in Neuroscience, 2020 The cholinergic system enhances attention and gates plasticity, making it a major regulator of adult learning. With aging, however, progressive degeneration of the cholinergic system impairs both the acquisition of new skills and functional recovery ...
J. Miguel Cisneros-Franco +16 more
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Astrocytes Modulate Somatostatin Interneuron Signaling in the Visual Cortex
Cells, 2022 At glutamatergic synapses, astrocytes respond to the neurotransmitter glutamate with intracellular Ca2+ elevations and the release of gliotransmitters that modulate synaptic transmission.
Vanessa Jorge Henriques +3 more
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Animals, 2022 This study aimed to evaluate the efficacy and safety of the SS DNA vaccine on growing pigs. Randomly, 147 pigs were divided into four groups, treatment 1 (T1, 3 × 109 CFU/mL, n = 39), T2 (3 × 108 CFU/mL, n = 35), T3 (3 × 107 CFU/mL, n = 35) and control ...
Chao Chen +5 more
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The position of combined medical treatment in acromegaly
Archives of Endocrinology and Metabolism, 2020 Advances in combination medical treatment have offer new perspectives for acromegaly patients with persistent disease activity despite receiving the available medical monotherapies.
Eva C. Coopmans +3 more
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Somatostatin and somatostatin receptors in retinal diseases [PDF]
European Journal of Endocrinology, 2000 Somatostatin is a small neuropeptide that is producedin the central nervous system, where it acts as aneurotransmitter. This neuropeptide also has animportant role in the neuroendocrine system as aninhibitor of hormone release, the most strikingexample of which is the inhibition of growth hormonerelease.
van, Hagen PM +7 more
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Long Acting Somatostatin Analogue: Clinical Potential for Gastrointestinal Disease
Canadian Journal of Gastroenterology, 1989 Name somatostatin is found throughout the gastrointestinal tract and has a wide variety of biological actions. Nevertheless, its short biological half-life and limited stability necessitate its use via continuous parenteral infusion and, thus, limits its
Richard N. Fedorak
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