Results 11 to 20 of about 68,999 (229)

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source

Loss of oligodendrocyte ErbB receptor signaling leads to hypomyelination, reduced density of parvalbumin‐expressing interneurons, and inhibitory function in the auditory cortex

Glia, Volume 71, Issue 2, Page 187-204, February 2023., 2023
Main Point Loss of oligodendrocyte ErbB receptor signaling leads to A1 hypomyelination, reduced PV expression and density of PV+ neurons and synapses, hypoconnectivity of inhibitory circuits and shift of the E/I balance towards excitation. Abstract For a long time, myelin was thought to be restricted to excitatory neurons, and studies on dysmyelination
Beatriz C. Borges, Xiangying Meng, Patrick Long, Patrick O. Kanold, Gabriel Corfas   +4 more
wiley   +1 more source

Positron emission tomography: Evolving modalities, radiopharmaceuticals and professional collaboration

Journal of Medical Radiation Sciences, Volume 69, Issue 4, Page 415-418, December 2022., 2022
PET has experienced exponential growth over the last few decades in terms of innovative technologies and novel radiopharmaceuticals. This has fostered increasing collaboration between radiographers and nuclear medicine technologists. Abstract Positron emission tomography (PET) as an imaging modality has undergone considerable innovation over the past ...
Sally L. Ayesa, Andrew Murphy
wiley   +1 more source

Altered expression of somatostatin signaling molecules and clock genes in the hippocampus of subjects with substance use disorder

Frontiers in Neuroscience, 2022
Substance use disorders are a debilitating group of psychiatric disorders with a high degree of comorbidity with major depressive disorder. Sleep and circadian rhythm disturbances are commonly reported in people with substance use disorder and major ...
Jake Valeri, Jake Valeri, Sinead M. O’Donovan, Wei Wang, David Sinclair, Ratna Bollavarapu, Barbara Gisabella, Barbara Gisabella, Donna Platt, Donna Platt, Craig Stockmeier, Craig Stockmeier, Harry Pantazopoulos, Harry Pantazopoulos   +13 more
doaj   +1 more source

Somatostatin receptor expression in parathyroid neoplasms

Endocrine Connections, 2019
Introduction: Parathyroid carcinoma represents a rare cause of primary hyperparathyroidism. Distinguishing carcinoma from the benign tumors underlying primary hyperparathyroidism remains challenging.
Sara Storvall, Helena Leijon, Eeva Ryhänen, Johanna Louhimo, Caj Haglund, Camilla Schalin-Jäntti, Johanna Arola   +6 more
doaj   +1 more source

Seizure-induced overexpression of NPY induces epileptic tolerance in a mouse model of spontaneous recurrent seizures

Frontiers in Molecular Neuroscience, 2022
Epileptic seizures result in pronounced over-expression of neuropeptide Y (NPY). In vivo and in vitro studies revealed that NPY exerts potent anticonvulsive actions through presynaptic Y2 receptors by suppressing glutamate release from principal neurons.
Meinrad Drexel, Günther Sperk
doaj   +1 more source

Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?

Frontiers in Pharmacology, 2013
Our knowledge of the pathophysiology of affect dysregulation has progressively increased, but the pharmacological treatments remain inadequate. Here, we summarize the current literature on deficits in somatostatin, an inhibitory modulatory neuropeptide ...
Li-Chun eLin, Etienne eSibille
doaj   +1 more source

Case report: Peritumoral hepatic steatosis in a patient with a metastatic somatostatin-producing oligosymptomatic neuroendocrine neoplasm

Frontiers in Oncology, 2022
Neuroendocrine neoplasms (NENs) comprise a heterogeneous collection of tumors derived from various neuroendocrine cells and are divided into functioning NEN and non-functioning NEN. Some NENs present with mild symptoms and can secrete somatostatin. These
Yuming Shao, Yang Gui, Yuejuan Cheng, Jia Xu, Xiaoyan Chang, Ke Lv   +5 more
doaj   +1 more source

Prediction of strain engineerings that amplify recombinant protein secretion through the machine learning approach MaLPHAS

Engineering Biology, Volume 6, Issue 4, Page 82-90, December 2022., 2022
Abstract This article presents a discussion of the process of precision fermentation (PF), describing the history of the space, the expected 70% growth over the next 5 years, various applications of precision fermented products, and the markets available to be disrupted by the technology. A range of prokaryotic and eukaryotic host organisms used for PF
Evgenia A. Markova, Rachel E. Shaw, Christopher R. Reynolds   +2 more
wiley   +1 more source

Molecular and functional characterization of somatostatin-type signalling in a deuterostome invertebrate [PDF]

Open Biology, 2020
Somatostatin (SS) and allatostatin-C (ASTC) are structurally and evolutionarily related neuropeptides that act as inhibitory regulators of physiological processes in mammals and insects, respectively.
Ya Zhang, Luis Alfonso Yañez Guerra, Michaela Egertová, Cleidiane G. Zampronio, Alexandra M. Jones, Maurice R. Elphick   +5 more
doaj   +1 more source