Results 11 to 20 of about 136,487 (285)

Bulk and Single-Nucleus Transcriptomics Highlight Intra-Telencephalic and Somatostatin Neurons in Alzheimer’s Disease

Frontiers in Molecular Neuroscience, 2022
Cortical neuron loss is a pathological hallmark of late-onset Alzheimer’s disease (AD). However, it remains unclear which neuronal subtypes beyond broad excitatory and inhibitory classes are most vulnerable.
Micaela E. Consens, Yuxiao Chen, Vilas Menon, Vilas Menon, Yanling Wang, Julie A. Schneider, Philip L. De Jager, Philip L. De Jager, David A. Bennett, Shreejoy J. Tripathy, Shreejoy J. Tripathy, Shreejoy J. Tripathy, Shreejoy J. Tripathy, Daniel Felsky, Daniel Felsky, Daniel Felsky, Daniel Felsky   +16 more
doaj   +1 more source

Somatostatin Analogues in the Treatment of Neuroendocrine Tumors: Past, Present and Future [PDF]

, 2019
In recent decades, the incidence of neuroendocrine tumors (NETs) has steadily increased. Due to the slow-growing nature of these tumors and the lack of early symptoms, most cases are diagnosed at advanced stages, when curative treatment options are no ...
Amthauer, Holger, Jann, Henning, Kayser, Antonin, Roderburg, Christoph, Stueven, Anna Kathrin, Tacke, Frank, Wetz, Christoph, Wiedenmann, Bertram, Wree, Alexander   +8 more
core   +1 more source

The therapeutic effect of the neuropeptide hormone somatostatin on Schistosoma mansoni caused liver fibrosis

BMC Infectious Diseases, 2005
Background The neuropeptide somatostatin is one of the major regulatory peptides in the central nervous system and the digestive tract. Our recent work has delineated an association between fibrosis and low levels of endogenous somatostatin plasma levels
Peeters Theo, Depoortere Inge, Vrolix Gunther, Chatterjee Shyama, Van Marck Eric   +4 more
doaj   +1 more source

VGF changes during the estrous cycle: a novel endocrine role for TLQP peptides? [PDF]

, 2014
Although the VGF derived peptide TLQP-21 stimulates gonadotropin-releasing hormone (GnRH) and gonadotropin secretion, available data on VGF peptides and reproduction are limited.
Brancia C, Cocco C, D'Amato F, Ferri G-L, Noli B   +4 more
core   +6 more sources

E-cadherin expression is associated with somatostatin analogue response in acromegaly [PDF]

, 2018
Acromegaly is a rare disease resulting from hypersecretion of growth hormone (GH) and insulin‐like growth factor 1 (IGF1) typically caused by pituitary adenomas, which is associated with increased mortality and morbidity. Somatostatin analogues (SSAs)
Cano, David A., Castaño, Justo P., Dios, Elena, Flores Martínez, Álvaro, Ibáñez Costa, Alejandro, Japón Rodríguez, Miguel Ángel, Luque, Raúl M., Madrazo Atutxa, Ainara, Soto Moreno, Alfonso Manuel, Venegas Moreno, Eva, Vázquez Borrego, Mari C.   +10 more
core   +1 more source

Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?

Frontiers in Pharmacology, 2013
Our knowledge of the pathophysiology of affect dysregulation has progressively increased, but the pharmacological treatments remain inadequate. Here, we summarize the current literature on deficits in somatostatin, an inhibitory modulatory neuropeptide ...
Li-Chun eLin, Etienne eSibille
doaj   +1 more source

Therapeutic effects of Bombax ceiba flower aqueous extracts against loperamide-induced constipation in mice

Pharmaceutical Biology, 2023
Context Bombax ceiba Linnaeus (Bombacaceae) is known as silk cotton tree, the flowers of which are used in many medicinal applications.Objective To investigate the therapeutic effect of B.
Liuping Wang, Shiyuan Xie, Xuan Jiang, Caini Xu, Youqiong Wang, Jianfang Feng, Bin Yang   +6 more
doaj   +1 more source

Approach of Acromegaly during Pregnancy

Diagnostics, 2022
Acromegaly-related sub/infertility, tidily related to suboptimal disease control (1/2 of cases), correlates with hyperprolactinemia (1/3 of patients), hypogonadotropic hypogonadism—mostly affecting the pituitary axis in hypopituitarism (10–80%), and ...
Alexandru Dan Popescu, Mara Carsote, Ana Valea, Andreea Gabriela Nicola, Ionela Teodora Dascălu, Tiberiu Tircă, Jaqueline Abdul-Razzak, Mihaela Jana Țuculină   +7 more
doaj   +1 more source

Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes [PDF]

, 2012
Conjugates of a dicarba analogue of octreotide, a potent somatostatin agonist whose receptors are overexpressed on tumor cells, with [PtCl 2(dap)] (dap = 1-(carboxylic acid)-1,2-diaminoethane) (3), [(η 6-bip)Os(4-CO 2-pico)Cl] (bip = biphenyl, pico ...
Alejandro González-Cantó, Algueró B., Anna Massaguer, Barragán F., Barragán F., Bauer W., Carlos González, Cascini G. L., Casini A., Chaplin A. B., Charvat T. T., de Jong M., Deshmukh M. V., Dirscherl G., Dolors Carrion-Salip, D’Addona D., Fischer R., Flavia Barragán, Gariepy J., Gasser G., Gianferrara T., Gossens C., Gross A., Hodson E., Hornick C. A., Hsieh H.-P., Huang C. M., Irene Gómez-Pinto, Jakupec M. A., Jakupec M. A., Janecka A., Jennerwein M., Koradi R., Kostrhunova H., Kostrhunova H., Levina A., Liu H.-K., Marchán V., Marchán V., Melacini G., Metzler-Nolte N., Mezo G., Moradell S., Moreno V., Morris R. E., Mukhopadhyay S., Novakova O., Okarvi S. M., Peacock A. F. A., Peacock A. F. A., Peacock A. F. A., Peindy N’Dongo H. W., Peter J. Sadler, Pizarro A. M., Puckett C. A., Rademaker-Lakhai J. M., Rafael de Llorens, Reubi J. C., Reubi J. C., Schaer J. C., Singh S. K., Splith K., Sun L.-C., Süss-Fink G., van Rijt S. H., van Rijt S. H., van Rijt S. H., van Rijt S. H., Vicente Marchán, Virtudes Moreno, Wang F., Wang F., Watson J. C., Wheate N. J., Wynants C., Wynants C., Zaccaro L., Zhang J., Zhang Y.   +78 more
core   +5 more sources

PET Imaging of Perceptual Learning-Induced Changes in the Aged Rodent Cholinergic System

Frontiers in Neuroscience, 2020
The cholinergic system enhances attention and gates plasticity, making it a major regulator of adult learning. With aging, however, progressive degeneration of the cholinergic system impairs both the acquisition of new skills and functional recovery ...
J. Miguel Cisneros-Franco, J. Miguel Cisneros-Franco, Patrice Voss, Patrice Voss, Min Su Kang, Min Su Kang, Maryse E. Thomas, Maryse E. Thomas, Jonathan Côté, Jonathan Côté, Karen Ross, Pierrette Gaudreau, David A. Rudko, Pedro Rosa-Neto, Pedro Rosa-Neto, Étienne de-Villers-Sidani, Étienne de-Villers-Sidani   +16 more
doaj   +1 more source