Results 21 to 30 of about 115,117 (314)
Circuit dissection of the role of somatostatin in itch and pain
Nature Neuroscience, 2018 Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood.
Jing Huang +14 more
semanticscholar +1 more source
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion
Nature Communications, 2019 Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels by stimulation of hepatic ...
E. Vergari +19 more
semanticscholar +1 more source
Cortical gamma band synchronization through somatostatin interneurons
Nature Neuroscience, 2017 Gamma band rhythms may synchronize distributed cell assemblies to facilitate information transfer within and across brain areas, yet their underlying mechanisms remain hotly debated.
Julia Veit +4 more
semanticscholar +1 more source
Radiolabeled Peptides for Cancer Imaging and Therapy: From Bench-to-Bedside
CHIMIA, 2021 Radiolabeled peptides can deliver radiation selectively to tumors via targeting peptide receptors that are overexpressed on the surface of cancer cells.
Rosalba Mansi, Melpomene Fani
doaj +1 more source
Pharmacological Reviews, 2018 Somatostatin, also known as somatotropin-release inhibitory factor, is a cyclopeptide that exerts potent inhibitory actions on hormone secretion and neuronal excitability. Its physiologic functions are mediated by five G protein–coupled receptors (GPCRs)
T. Günther +12 more
semanticscholar +1 more source
Somatostatin in gastroenterology [PDF]
BMJ, 1994 Somatostatin was isolated from ovine hypothalamus in 1973, and eight years later a long acting analogue, octreotide, was synthesised. More than 1000 clinical applications have since been suggested for these paninhibitory peptides, particularly in gastroenterology.
Arthur Shulkes, Jeremy S. Wilson
openaire +2 more sources
Adrenal cortex in peripubertal and adult female rats after neonatal treatment with SRIH-14 [PDF]
Archives of Biological Sciences, 2008 Neonatal female rats (3-7 days old) were injected subcutaneously twice daily with 20 μg of SRIH-14/100g b.w. for five consecutive days. The animals were sacrificed in the peripubertal (38 days old) or adult (80 days old) periods of life.
Milošević Verica +6 more
doaj +1 more source
Somatostatin and Somatostatin Receptors in Tumour Biology
International Journal of Molecular Sciences, 2023 Somatostatin (SST), a growth hormone inhibitory peptide, is expressed in endocrine and non-endocrine tissues, immune cells and the central nervous system (CNS). Post-release from secretory or immune cells, the first most appreciated role that SST exhibits is the antiproliferative effect in target tissue that served as a potential therapeutic ...
openaire +2 more sources
Theranostics, 2017 Background: PET scans using FDG and somatostatin receptor imaging agents have both been used to study neuroendocrine tumours. Most reports have documented the sensitivity and specificity of each radiopharmaceutical independently, and even suggested the ...
D. Chan +14 more
semanticscholar +1 more source
Frontiers in Neural Circuits, 2022 Neuropeptides, a diverse class of signaling molecules in the nervous system, modulate various biological effects including membrane excitability, synaptic transmission and synaptogenesis, gene expression, and glial cell architecture and function. To date,
Sanne M. Casello +9 more
doaj +1 more source