Results 21 to 30 of about 170,108 (362)

Cellular mechanisms underlying central sensitization in a mouse model of chronic muscle pain

eLife, 2022
Chronic pain disorders are often associated with negative emotions, including anxiety and depression. The central nucleus of the amygdala (CeA) has emerged as an integrative hub for nociceptive and affective components during central pain development ...
Yu-Ling Lin, Zhu-Sen Yang, Wai-Yi Wong, Shih-Che Lin, Shuu-Jiun Wang, Shih-Pin Chen, Jen-Kun Cheng, Hui Lu, Cheng-Chang Lien   +8 more
doaj   +1 more source

Somatostatin receptor expression in parathyroid neoplasms

Endocrine Connections, 2019
Introduction: Parathyroid carcinoma represents a rare cause of primary hyperparathyroidism. Distinguishing carcinoma from the benign tumors underlying primary hyperparathyroidism remains challenging.
Sara Storvall, Helena Leijon, Eeva Ryhänen, Johanna Louhimo, Caj Haglund, Camilla Schalin-Jäntti, Johanna Arola   +6 more
doaj   +1 more source

A δ-cell subpopulation with a pro-β-cell identity contributes to efficient age-independent recovery in a zebrafish model of diabetes

eLife, 2022
Restoring damaged β-cells in diabetic patients by harnessing the plasticity of other pancreatic cells raises the questions of the efficiency of the process and of the functionality of the new Insulin-expressing cells.
Claudio Andrés Carril Pardo, Laura Massoz, Marie A Dupont, David Bergemann, Jordane Bourdouxhe, Arnaud Lavergne, Estefania Tarifeño-Saldivia, Christian SM Helker, Didier YR Stainier, Bernard Peers, Marianne M Voz, Isabelle Manfroid   +11 more
doaj   +1 more source

Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular Ca2+ release [PDF]

, 2019
© 2019 Denwood et al.Somatostatin secretion from pancreatic islet δ-cells is stimulated by elevated glucose levels, but the underlying mechanisms have only partially been elucidated.
Denwood, Geoffrey, Gribble, Fiona, Nikolaev, Viacheslav O, Ramracheya, Reshma, Reimann, Frank, Rorsman, Patrik, Salehi, Albert, Seino, Susumo, Takahashi, Harumi, Tarasov, Andrei, Vergari, Elisa, Zhang, Quan   +11 more
core   +1 more source

Regulatory Mechanisms of Somatostatin Expression

International Journal of Molecular Sciences, 2020
Somatostatin is a peptide hormone, which most commonly is produced by endocrine cells and the central nervous system. In mammals, somatostatin originates from pre-prosomatostatin and is processed to a shorter form, i.e., somatostatin-14, and a longer ...
Emmanuel Ampofo, Lisa Nalbach, M. Menger, M. Laschke   +3 more
semanticscholar   +1 more source

The therapeutic effect of the neuropeptide hormone somatostatin on Schistosoma mansoni caused liver fibrosis

BMC Infectious Diseases, 2005
Background The neuropeptide somatostatin is one of the major regulatory peptides in the central nervous system and the digestive tract. Our recent work has delineated an association between fibrosis and low levels of endogenous somatostatin plasma levels
Peeters Theo, Depoortere Inge, Vrolix Gunther, Chatterjee Shyama, Van Marck Eric   +4 more
doaj   +1 more source

Prediction of strain engineerings that amplify recombinant protein secretion through the machine learning approach MaLPHAS

Engineering Biology, Volume 6, Issue 4, Page 82-90, December 2022., 2022
Abstract This article presents a discussion of the process of precision fermentation (PF), describing the history of the space, the expected 70% growth over the next 5 years, various applications of precision fermented products, and the markets available to be disrupted by the technology. A range of prokaryotic and eukaryotic host organisms used for PF
Evgenia A. Markova, Rachel E. Shaw, Christopher R. Reynolds   +2 more
wiley   +1 more source

Dedicated hippocampal inhibitory networks for locomotion and immobility [PDF]

, 2017
Network activity is strongly tied to animal movement; however, hippocampal circuits selectively engaged during locomotion or immobility remain poorly characterized.
Arriaga, Moises, Han, Edward B
core   +2 more sources

Somatostatin Analogues in the Treatment of Neuroendocrine Tumors: Past, Present and Future [PDF]

, 2019
In recent decades, the incidence of neuroendocrine tumors (NETs) has steadily increased. Due to the slow-growing nature of these tumors and the lack of early symptoms, most cases are diagnosed at advanced stages, when curative treatment options are no ...
Amthauer, Holger, Jann, Henning, Kayser, Antonin, Roderburg, Christoph, Stueven, Anna Kathrin, Tacke, Frank, Wetz, Christoph, Wiedenmann, Bertram, Wree, Alexander   +8 more
core   +1 more source

Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output

Nature Communications, 2019
The formation and maintenance of spatial representations within hippocampal cell assemblies is strongly dictated by patterns of inhibition from diverse interneuron populations.
Matt Udakis, Victor Pedrosa, S. Chamberlain, C. Clopath, J. Mellor   +4 more
semanticscholar   +1 more source