Results 21 to 30 of about 179,431 (364)

Regulatory Mechanisms of Somatostatin Expression

International Journal of Molecular Sciences, 2020
Somatostatin is a peptide hormone, which most commonly is produced by endocrine cells and the central nervous system. In mammals, somatostatin originates from pre-prosomatostatin and is processed to a shorter form, i.e., somatostatin-14, and a longer ...
Emmanuel Ampofo, Lisa Nalbach, M. Menger, M. Laschke   +3 more
semanticscholar   +1 more source

Recent Advances in the Modeling of Alzheimer’s Disease

Frontiers in Neuroscience, 2022
Since 1995, more than 100 transgenic (Tg) mouse models of Alzheimer’s disease (AD) have been generated in which mutant amyloid precursor protein (APP) or APP/presenilin 1 (PS1) cDNA is overexpressed (1st generation models).
Hiroki Sasaguri, Shoko Hashimoto, Naoto Watamura, Kaori Sato, Kaori Sato, Risa Takamura, Risa Takamura, Kenichi Nagata, Satoshi Tsubuki, Toshio Ohshima, Atsushi Yoshiki, Kenya Sato, Kenya Sato, Wakako Kumita, Wakako Kumita, Erika Sasaki, Erika Sasaki, Shinobu Kitazume, Per Nilsson, Bengt Winblad, Takashi Saito, Takashi Saito, Nobuhisa Iwata, Takaomi C. Saido   +23 more
doaj   +1 more source

Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes [PDF]

, 2012
Conjugates of a dicarba analogue of octreotide, a potent somatostatin agonist whose receptors are overexpressed on tumor cells, with [PtCl 2(dap)] (dap = 1-(carboxylic acid)-1,2-diaminoethane) (3), [(η 6-bip)Os(4-CO 2-pico)Cl] (bip = biphenyl, pico ...
Alejandro González-Cantó, Algueró B., Anna Massaguer, Barragán F., Barragán F., Bauer W., Carlos González, Cascini G. L., Casini A., Chaplin A. B., Charvat T. T., de Jong M., Deshmukh M. V., Dirscherl G., Dolors Carrion-Salip, D’Addona D., Fischer R., Flavia Barragán, Gariepy J., Gasser G., Gianferrara T., Gossens C., Gross A., Hodson E., Hornick C. A., Hsieh H.-P., Huang C. M., Irene Gómez-Pinto, Jakupec M. A., Jakupec M. A., Janecka A., Jennerwein M., Koradi R., Kostrhunova H., Kostrhunova H., Levina A., Liu H.-K., Marchán V., Marchán V., Melacini G., Metzler-Nolte N., Mezo G., Moradell S., Moreno V., Morris R. E., Mukhopadhyay S., Novakova O., Okarvi S. M., Peacock A. F. A., Peacock A. F. A., Peacock A. F. A., Peindy N’Dongo H. W., Peter J. Sadler, Pizarro A. M., Puckett C. A., Rademaker-Lakhai J. M., Rafael de Llorens, Reubi J. C., Reubi J. C., Schaer J. C., Singh S. K., Splith K., Sun L.-C., Süss-Fink G., van Rijt S. H., van Rijt S. H., van Rijt S. H., van Rijt S. H., Vicente Marchán, Virtudes Moreno, Wang F., Wang F., Watson J. C., Wheate N. J., Wynants C., Wynants C., Zaccaro L., Zhang J., Zhang Y.   +78 more
core   +5 more sources

VGF changes during the estrous cycle: a novel endocrine role for TLQP peptides? [PDF]

, 2014
Although the VGF derived peptide TLQP-21 stimulates gonadotropin-releasing hormone (GnRH) and gonadotropin secretion, available data on VGF peptides and reproduction are limited.
Brancia C, Cocco C, D'Amato F, Ferri G-L, Noli B   +4 more
core   +6 more sources

Dedicated hippocampal inhibitory networks for locomotion and immobility [PDF]

, 2017
Network activity is strongly tied to animal movement; however, hippocampal circuits selectively engaged during locomotion or immobility remain poorly characterized.
Arriaga, Moises, Han, Edward B
core   +2 more sources

Treatment options for PNET liver metastases. a systematic review [PDF]

, 2018
Pancreatic neuroendocrine tumors (PNETs) are rare pancreatic neoplasms. About 40-80% of patients with PNET are metastatic at presentation, usually involving the liver (40-93%). Liver metastasis represents the most significant prognostic factor.
Aurello, Paolo, Crovetto, Anna, Debs, Tarek, Mangogna, Livia Maria, Moschetta, Giovanni, Nigri, Giuseppe, Persechino, Raffaello, Petrucciani, Niccolò, Ramacciato, Giovanni   +8 more
core   +1 more source

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

Nature Communications, 2019
Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels by stimulation of hepatic ...
E. Vergari, J. Knudsen, R. Ramracheya, A. Salehi, Quan Zhang, J. Adam, I. W. Asterholm, A. Benrick, L. Briant, M. Chibalina, F. Gribble, A. Hamilton, Benoît Hastoy, F. Reimann, Nils J. G. Rorsman, Ioannis Spiliotis, A. Tarasov, Yanling Wu, F. Ashcroft, P. Rorsman   +19 more
semanticscholar   +1 more source

Growth Hormone (GH)-Releasing Peptide Stimulation of GH Release from Human Somatotroph Adenoma Cells: Interaction with GH-Releasing Hormone, Thyrotropin- Releasing Hormone, and Octreotide. [PDF]

, 1994
The synthetic hexapeptide GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) specifically stimulates GH secretion in humans in vivo and in animals in vitro and in vivo via a still unknown receptor and mechanism.
Brockmeier, S., Lange, M., Müller, Otto-Albrecht, Renner, U., Schopohl, Jochen, Stalla, G. K., Strasburger, Christian J., Werder, K. von   +7 more
core   +1 more source

Cortical gamma band synchronization through somatostatin interneurons

Nature Neuroscience, 2017
Gamma band rhythms may synchronize distributed cell assemblies to facilitate information transfer within and across brain areas, yet their underlying mechanisms remain hotly debated.
Julia Veit, Richard Hakim, Monika P. Jadi, T. Sejnowski, H. Adesnik   +4 more
semanticscholar   +1 more source

Effect of Intraduodenal Bile and Taurodeoxycholate on Exocrine Pancreatic Secretion and on Plasma Levels of Vasoactive Intestinal Polypeptide and Somatostatin in Man [PDF]

, 1994
Intraduodenal (i.d.) application of bile or Na-taurodeoxycholate (TDC) dose dependently enhances basal exocrine pancreatic secretion. The hydrokinetic effect is mediated at least in part by secretin.
Fiedler, Fritz, Lehnert, Peter, Riepl, Rudolf L., Teufel, Johannes   +3 more
core   +1 more source