Results 41 to 50 of about 115,117 (314)

Hyperactive Somatostatin Interneurons Contribute to Excitotoxicity in Neurodegenerative Disorders

Nature Neuroscience, 2016
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlapping neurodegenerative disorders whose pathogenesis remains largely unknown.
Wen Zhang, Lifeng Zhang, Bo Liang, D. Schroeder, Zhong-wei Zhang, G. Cox, Yun Li, Da-Ting Lin   +7 more
semanticscholar   +1 more source

Expression of somatostatin receptors in hemangioblastomas associated with von Hippel-Lindau disease as a novel diagnostic, therapeutic, and follow-up opportunity: A case report and literature review

Archives of Endocrinology and Metabolism
SUMMARY Hemangioblastomas associated with von Hippel-Lindau (VHL) disease are frequently multiple and recur during prolonged follow-up. Currently, no systemic treatment is available for these tumors.
Eloá Pereira Brabo, Sergio Altino de Almeida, Patrícia Piazza Rafful, Paulo Henrique Rosado-de-Castro, Leonardo Vieira Neto   +4 more
doaj   +1 more source

δ-Cells: The Neighborhood Watch in the Islet Community

Biology, 2021
Somatostatin-secreting δ-cells have aroused great attention due to their powerful roles in coordination of islet insulin and glucagon secretion and maintenance of glucose homeostasis.
Rui Gao, Tao Yang, Quan Zhang
doaj   +1 more source

Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion

Nature Network Boston, 2015
The peptide hormone urocortin3 (Ucn3) is abundantly expressed by mature beta cells, yet its physiological role is unknown. Here we demonstrate that Ucn3 is stored and co-released with insulin and potentiates glucose-stimulated somatostatin secretion via ...
T. van der Meulen, C. Donaldson, Elena Cáceres, Anna E Hunter, Christopher Cowing-Zitron, Lynley D. Pound, Michael W Adams, Andreas Zembrzycki, K. Grove, M. Huising   +9 more
semanticscholar   +1 more source

Engineering a Human‐Sized Common Bile Duct Prototype with Regenerative Potential: In Vitro Evaluation of Mechanics, Function, Degradation, and Immune Modulation

Advanced Healthcare Materials, EarlyView.
This study presents a multiphasic bile duct construct composed of biocompatible materials and cells, featuring an inner layer that supports biliary epithelium growth, a middle layer providing mechanical strength, and an outer cell‐permissive layer designed to support future in vivo integration.
Mattia Pasqua, Marianna Barbuto, Matteo Calligaris, Roberto Di Gesù, Duilio Pagano, Rosalia Busà, Salvatore Gruttadauria, Simone Dario Scilabra, Antonio D'Amore, Maria Giovanna Francipane   +9 more
wiley   +1 more source

Developing a 3-D computational model of neurons in the central amygdala to understand pharmacological targets for pain

Frontiers in Pain Research, 2023
Neuropathic and nociplastic pain are major causes of pain and involve brain areas such as the central nucleus of the amygdala (CeA). Within the CeA, neurons expressing protein kinase c-delta (PKCδ) or somatostatin (SST) have opposing roles in pain-like ...
Rachael Miller Neilan, Carley Reith, Iniya Anandan, Kayla Kraeuter, Kayla Kraeuter, Heather N. Allen, Heather N. Allen, Benedict J. Kolber   +7 more
doaj   +1 more source

Somatostatin and Somatostatin-Containing Neurons in Shaping Neuronal Activity and Plasticity

Front. Neural Circuits, 2016
Since its discovery over four decades ago, somatostatin (SOM) receives growing scientific and clinical interest. Being localized in the nervous system in a subset of interneurons somatostatin acts as a neurotransmitter or neuromodulator and its role in ...
M. Liguz-Lęcznar, J. Urban-Ciećko, M. Kossut   +2 more
semanticscholar   +1 more source

Comprehensive Characterization of Bihormonal Cells and Endocrine Cell Lineages in Mammalian Pancreatic Islets

Advanced Science, EarlyView.
This study integrates dual‐reporter genetics, imaging flow cytometry, and single‐cell sequencing to characterize rare bihormonal cells in mouse and human pancreatic islets. Gcg⁺Ins⁺ cells resemble α‐cells rather than transitional states. Cross‐species gene network analysis refines islet cell taxonomy and reveals human‐specific δ‐cell subtypes ...
Xin‐Xin Yu, Peng Peng, Yi‐Ning Wang, Mao‐Yang He, Shuang He, Chen‐Tao Jin, Liu Yang, Xi Wang, Jia‐Xi Zheng, Jie Gao, Cheng‐Ran Xu   +10 more
wiley   +1 more source

On implications of somatostatin in diabetic retinopathy

Neural Regeneration Research
Somatostatin, a naturally produced neuroprotective peptide, depresses excitatory neurotransmission and exerts anti-proliferative and anti-inflammatory effects on the retina.
Yanhong Fang, Qionghua Wang, Youjian Li, Li Zeng, Jian Liu, Kepeng Ou   +5 more
doaj   +1 more source

A scalable platform for the development of cell-type-specific viral drivers

eLife, 2019
Enhancers are the primary DNA regulatory elements that confer cell type specificity of gene expression. Recent studies characterizing individual enhancers have revealed their potential to direct heterologous gene expression in a highly cell-type-specific
Sinisa Hrvatin, Christopher P Tzeng, M Aurel Nagy, Hume Stroud, Charalampia Koutsioumpa, Oren F Wilcox, Elena G Assad, Jonathan Green, Christopher D Harvey, Eric C Griffith, Michael E Greenberg   +10 more
doaj   +1 more source