Results 41 to 50 of about 179,431 (364)
Angewandte Chemie, EarlyView.A one‐step multi‐component synthetic approach is reported to construct α‐aryl‐substituted DOTAs, which required tedious multi‐step synthesis in all previous works. The synthesized α‐aryl‐substituted DOTAs showed improved performance for developing multifunctional theranostics and represent a universal platform for bioconjugation. Abstract α‐Substituted
Pak‐Lun Lam +8 more
wiley +2 more sources
Prophylactic effect of somatostatin in preventing Post-ERCP pancreatitis: an updated meta-analysis
The Saudi Journal of Gastroenterology, 2015 Background/Aims: Somatostatin is regarded as a prophylactic agent on post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP), but studies are still controversial. Materials and Methods: Electronic databases, including PubMed, EMBASE,
Xie Qin +3 more
doaj +1 more source
Human Pancreas GH-Releasing Factor Analog Restores High-Amplitude GH Pulses in CNS Lesion-Induced GH Deficiency [PDF]
, 1983 Lesions of the ventromedial-arcuate (VMH-ARC) region of the hypothalamus result in impaired growth accompanied by a marked suppression in spontaneous GH secretory bursts. We studied the effects of an analog of the recently characterized human pancreas GH-
Eikelboom, Rudy +2 more
core +2 more sources
Theranostics, 2017 Background: PET scans using FDG and somatostatin receptor imaging agents have both been used to study neuroendocrine tumours. Most reports have documented the sensitivity and specificity of each radiopharmaceutical independently, and even suggested the ...
D. Chan +14 more
semanticscholar +1 more source
Fluorescent ligands for studying neuropeptide receptors by confocal microscopy
Brazilian Journal of Medical and Biological Research, 1998 This paper reviews the use of confocal microscopy as it pertains to the identification of G-protein coupled receptors and the study of their dynamic properties in cell cultures and in mammalian brain following their tagging with specific fluorescent ...
A. Beaudet +5 more
doaj +1 more source
Somatostatin and somatostatin receptors in Cushing's disease [PDF]
Molecular and Cellular Endocrinology, 2008 Cushing's disease is caused by an ACTH secreting pituitary adenoma. Surgery is the treatment of choice and cure rates between 60 and 90% are reported. For patients in which surgery fails, effective medical treatment options are needed. Somatostatin (SS) receptors (sst) are expressed on normal and tumoral corticotroph cells.
openaire +5 more sources
Somatostatin Neurons in the Basal Forebrain Promote High-Calorie Food Intake
Cell Reports, 2017 Obesity has become a global issue, and the overconsumption of food is thought to be a major contributor. However, the regulatory neural circuits that regulate palatable food consumption remain unclear.
Chen Zhu +8 more
doaj +1 more source
Frontiers in Neuroscience, 2019 The anatomical and functional characterization of somatostatin (SST) and somatostatin receptors (SSTRs) within the spinal cord have been focused in the dorsal horn, specifically in relation to sensory afferent processing.
Belinda R. Bowman +6 more
doaj +1 more source
Clinical Applications of Somatostatin Receptor (Agonist) PET Tracers beyond Neuroendocrine Tumors
Diagnostics, 2022 Somatostatin receptor (SSTR) agonist tracers used in nuclear medicine scans are classically used for neuroendocrine tumor diagnosis and staging. SSTR are however, expressed more widely in a variety of cells as seen in the distribution of physiological ...
Rasmus Helgebostad +5 more
doaj +1 more source
Biomedicines, 2022 During brain development, neurite formation plays a critical role in neuronal communication and cognitive function. In the present study, we compared developmental changes in the expression of crucial markers that govern the functional activity of ...
Sneha Singh +2 more
doaj +1 more source