Results 41 to 50 of about 68,999 (229)
On implications of somatostatin in diabetic retinopathy
Neural Regeneration ResearchSomatostatin, a naturally produced neuroprotective peptide, depresses excitatory neurotransmission and exerts anti-proliferative and anti-inflammatory effects on the retina.
Yanhong Fang +5 more
doaj +1 more source
δ-Cells: The Neighborhood Watch in the Islet Community
Biology, 2021 Somatostatin-secreting δ-cells have aroused great attention due to their powerful roles in coordination of islet insulin and glucagon secretion and maintenance of glucose homeostasis.
Rui Gao, Tao Yang, Quan Zhang
doaj +1 more source
Designed Biomaterial‐Enhanced Cell Transplantation for Neural Tissue Engineering
Aggregate, EarlyView.Biomaterials offer a promising solution for cell transplantation in the central nervous system by creating a protective environment that enhances cell survival, integration, and functional recovery in preclinical models of neurological disorders. ABSTRACT Cell transplantation therapy in the central nervous system is hindered by limited survival and ...
Yun Tang +3 more
wiley +1 more source
A scalable platform for the development of cell-type-specific viral drivers
eLife, 2019 Enhancers are the primary DNA regulatory elements that confer cell type specificity of gene expression. Recent studies characterizing individual enhancers have revealed their potential to direct heterologous gene expression in a highly cell-type-specific
Sinisa Hrvatin +10 more
doaj +1 more source
Frontiers in Pain Research, 2023 Neuropathic and nociplastic pain are major causes of pain and involve brain areas such as the central nucleus of the amygdala (CeA). Within the CeA, neurons expressing protein kinase c-delta (PKCδ) or somatostatin (SST) have opposing roles in pain-like ...
Rachael Miller Neilan +7 more
doaj +1 more source
TP53‐Mutated Myeloid Neoplasms: 2024 Update on Diagnosis, Risk‐Stratification, and Management
American Journal of Hematology, EarlyView.ABSTRACT Alterations in the tumor suppressor gene TP53 are common in human cancers and are associated with an aggressive nature. Approximately 8%–12% of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) harbor TP53 mutations (TP53mut) and present immense challenges due to inherent chemoresistance and poor outcomes.
Mithun Vinod Shah +2 more
wiley +1 more source
Genome survey sequence of black carp provides insights into development‐related gene duplications
Journal of the World Aquaculture Society, Volume 53, Issue 6, Page 1197-1214, December 2022., 2022 Abstract As one of the traditional "Four Domesticated Fishes" in China, black carp (Mylopharyngodon piceus) is an important species in freshwater aquaculture, an important fishery resource in China, and an invasive species in the United Sates. Here, we reported the draft genome of black carp with an estimated size of 975 Mb and 27,541 predicted protein‐
Ying Lu +10 more
wiley +1 more source
Frontiers in Endocrinology, 2023 IntroductionAn orally administered amino acid-based test supplement was recently shown to increase human growth hormone (hGH) in healthy adults. This prospective, observational, single-center, single-arm cohort study investigated the effects of 24 weeks ...
Susan Pekarovics +6 more
doaj +1 more source
Distinct Alterations of Inflammatory Biomarkers in Cluster Headache: A Case Control Study
Annals of Neurology, EarlyView.Objective Investigate the immune system's role in cluster headache by analyzing cytokines in people with cluster headache and headache‐free controls, and explore if certain cytokines could predict a specific phenotype. Methods We measured 45 cytokines in adult participants from the Danish Cluster Headache Biobank in a prospective case–control setup ...
Nunu Laura Timotheussen Lund +6 more
wiley +1 more source
Frontiers in PharmacologyGlucose homeostasis is primarily maintained by pancreatic hormones, insulin and glucagon, with an emerging role for a third islet hormone, somatostatin, in regulating insulin and glucagon responses.
Emily G. Hoffman +3 more
doaj +1 more source