Results 41 to 50 of about 76,426 (249)

Acromegaly in the elderly patient

Archives of Endocrinology and Metabolism, 2020
Acromegaly is an insidious disease, usually resulting from growth hormone hypersecretion by a pituitary adenoma. It is most often diagnosed during the 3rd to 4th decade of life.
Raquel S. Jallad, Marcello D. Bronstein
doaj   +1 more source

Hippocampal Somatostatin Interneurons, Long-Term Synaptic Plasticity and Memory

Frontiers in Neural Circuits, 2021
A distinctive feature of the hippocampal structure is the diversity of inhibitory interneurons. These complex inhibitory interconnections largely contribute to the tight modulation of hippocampal circuitry, as well as to the formation and coordination of
Eve Honoré, Abdessattar Khlaifia, Anthony Bosson, Jean-Claude Lacaille   +3 more
doaj   +1 more source

Somatostatin radioimmunoassay with 125I-N.ALPHA.-tyrosyl-somatostatin.

Endocrinologia Japonica, 1978
Nalpha-Tyrosyl-somatostatin was synthesized and proved to be homogeneous. Radioiodination of this tyrosine-containing somatostatin analogue by either the lactoperoxidase method or the chloramine T method led to the formation of crude iodinated compound, which was purified by ion exchange chromatography on CM-Sephadex C-25 using a linear ammonium ...
N, Yanaihara, H, Sato, N, Sakura, C, Yanaihara   +3 more
openaire   +3 more sources

Calcium Channel Blockers Inhibit Pancreatic Neuroendocrine Neoplasms Progression via Cav1.2‐Epigenetic Circuit

Advanced Science, EarlyView.
Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu, Qiongcong Xu, Jinzhao Xie, Mingjian Ma, Xitai Huang, Yinhao Shi, Jiawei Zhou, Enliang Zhu, Ziyi Zhao, Ning Zhang, Zhide Liu, Jingyuan Ye, Xiaoyu Yin   +12 more
wiley   +1 more source

DMAP-assisted sulfonylation as an efficient step for the methylation of primary amine motifs on solid support

Beilstein Journal of Organic Chemistry, 2017
Several multistep strategies were developed to ensure single methylation of amines on solid support. These strategies rely on the introduction of the o-NBS protecting/activating group as a key step.
Johnny N. Naoum, Koushik Chandra, Dorit Shemesh, R. Benny Gerber, Chaim Gilon, Mattan Hurevich   +5 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

In Silico, In Vitro and In Vivo Pharmacodynamic Characterization of Novel Analgesic Drug Candidate Somatostatin SST4 Receptor Agonists

Frontiers in Pharmacology, 2021
Background: Somatostatin released from the capsaicin-sensitive sensory nerves mediates analgesic and anti-inflammatory effects via its receptor subtype 4 (SST4) without influencing endocrine functions.
Boglárka Kántás, Boglárka Kántás, Éva Szőke, Éva Szőke, Éva Szőke, Rita Börzsei, Péter Bánhegyi, Junaid Asghar, Lina Hudhud, Lina Hudhud, Anita Steib, Anita Steib, Ágnes Hunyady, Ágnes Hunyady, Ádám Horváth, Ádám Horváth, Angéla Kecskés, Angéla Kecskés, Éva Borbély, Éva Borbély, Csaba Hetényi, Csaba Hetényi, Gábor Pethő, Gábor Pethő, Erika Pintér, Erika Pintér, Erika Pintér, Erika Pintér, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes   +31 more
doaj   +1 more source

Highly variable biodistribution of 68Ga labeled somatostatin analogues 68Ga-DOTA-NOC and 68Ga-DOTA-TATE in neuroendocrine tumors: clinical implications for somatostatin receptor directed PET/CT [PDF]

, 2022
Monica Cheng, Mark Tann
openalex   +1 more source

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

Advanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu, Zhi‐Bin Hu, Ling Hu, Yu‐Bing Wang, Qiong Zhang, Ning‐Ning Song, Xi‐Yue Liu, Jia‐Yin Chen, Hong‐Wen Zhu, Bing‐Yao Zhou, Yun‐Chao Tao, Li Zhao, Ze‐Xuan Li, Yi‐Wei Li, Jia‐Qi Chen, Si‐Xin Tu, Cong‐Cong Qi, Sai‐Dan Ding, Gang Peng, Lin Xu, Yu‐Qiang Ding   +20 more
wiley   +1 more source

Inhibitory Circuits in the Basolateral Amygdala in Aversive Learning and Memory

Frontiers in Neural Circuits, 2021
Neural circuits in the basolateral amygdala (BLA) play a pivotal role in the learning and memory formation, and processing of emotionally salient experiences, particularly aversive ones.
Madhusoothanan B. Perumal, Pankaj Sah, Pankaj Sah, Pankaj Sah   +3 more
doaj   +1 more source