Results 61 to 70 of about 136,487 (285)

Bio‐Inspired Pancreas With Microfluidic Multi‐Component Hydrogel Microfibers for Exploring Pancreatic Exocrine and Endocrine Interactions

Aggregate, EarlyView.
A bionic pancreas model incorporating core‐shell microfibers that encapsulate pancreatic stellate cells (PSCs) and β‐cells provides valuable insights into PSCs activation, cell‐cell interactions, and diabetes progression. Furthermore, the potential of this bio‐inspired pancreas for drug screening is demonstrated by testing with a glucagon‐like peptide ...
Zhikun Huan, Zhiqiang Luo, Jingbo Li, Yunru Yu, Ling Li   +4 more
wiley   +1 more source

In Silico, In Vitro and In Vivo Pharmacodynamic Characterization of Novel Analgesic Drug Candidate Somatostatin SST4 Receptor Agonists

Frontiers in Pharmacology, 2021
Background: Somatostatin released from the capsaicin-sensitive sensory nerves mediates analgesic and anti-inflammatory effects via its receptor subtype 4 (SST4) without influencing endocrine functions.
Boglárka Kántás, Boglárka Kántás, Éva Szőke, Éva Szőke, Éva Szőke, Rita Börzsei, Péter Bánhegyi, Junaid Asghar, Lina Hudhud, Lina Hudhud, Anita Steib, Anita Steib, Ágnes Hunyady, Ágnes Hunyady, Ádám Horváth, Ádám Horváth, Angéla Kecskés, Angéla Kecskés, Éva Borbély, Éva Borbély, Csaba Hetényi, Csaba Hetényi, Gábor Pethő, Gábor Pethő, Erika Pintér, Erika Pintér, Erika Pintér, Erika Pintér, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes   +31 more
doaj   +1 more source

Adropin modulates pancreatic cell proliferation and glutathione levels in an animal model of type 1 diabetes mellitus

Animal Models and Experimental Medicine, EarlyView.
Adropin is related to the energy homeostasis‐associated gene. It significantly increased glutathione reductase enzyme levels in the pancreas of experimental diabetic rats. Adropin may reduce the severity of diabetes and its complications. Cell proliferation in the exocrine is reduced after the administration of adropin.
Ifrah I. Ali, Crystal D'Souza, Abderrahim Nemmar, Shreesh Ojha, Ernest A. Adeghate   +4 more
wiley   +1 more source

Inhibitory Circuits in the Basolateral Amygdala in Aversive Learning and Memory

Frontiers in Neural Circuits, 2021
Neural circuits in the basolateral amygdala (BLA) play a pivotal role in the learning and memory formation, and processing of emotionally salient experiences, particularly aversive ones.
Madhusoothanan B. Perumal, Pankaj Sah, Pankaj Sah, Pankaj Sah   +3 more
doaj   +1 more source

Radiation emergency medical countermeasures: Current formulary, identified gaps, and future approaches

Animal Models and Experimental Medicine, EarlyView.
Current radiation medical countermeasures primarily focus on hematopoietic acute radiation syndrome (H‐ARS) using agents like granulocyte colony‐stimulating factor (G‐CSF), granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), and romiplostim, alongside treatments for internal contamination (Prussian blue, diethylenetriamine pentaacetate [DTPA ...
Wen‐Bing Ma, Rong‐Hua Yin, Guang‐Ming Ren, Yin Zhang, Li‐Juan Li, Wei Liu, Ting Chen, Wei Zhou, Mian Zu, Rong‐Ling Yin, Xin‐Di Shi, Lei Wang, Xiao‐Ming Yang   +12 more
wiley   +1 more source

Effect of vitamin D3 and a stinging nettle extract on the gastric tissue of rats administered with trinitrobenzene sulfonic acid

Veterinární Medicína
In this study, the effects of vitamin D3 (Vit. D) and a stinging nettle (Urtica dioica L. (UD)) extract were examined using histopathological and immunohistochemical methods in the stomach tissues of an experimentally created rat model of CD.
A Gezer, S Yediel Aras, N Kilic Baygutalp, E Karadag Sari, G Bedir, B Mokhtare, K Yilmaz   +6 more
doaj   +1 more source

Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions

Frontiers in Cellular Neuroscience, 2019
Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be precipitated by exposure to chronic stress.
Manoela V. Fogaça, Ronald S. Duman
doaj   +1 more source

No mortality difference following treatment with terlipressin or somatostatin in cirrhotic patients with gastric variceal hemorrhage

The Saudi Journal of Gastroenterology, 2016
Background/Aims: The aim of this study was to compare the efficacy of terlipressin versus somatostatin as adjuvants to endoscopic treatment in cirrhotic patients with gastric variceal bleeding. Patients and Methods: The National Health Insurance Database,
Tsung-Hsing Hung, Chen-Chi Tsai, guo-Chih TsenK, Yu-Hsi Hsieh, Chih-Wei Tseng   +4 more
doaj   +1 more source

Effects of Ostertagia circumcincta larvae and adult parasites on abomasal and intestinal tissues in sheep : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Physiology [PDF]

, 1994
Ostertagia circumcincta parasites infect the abomasum of sheep causing damage to the abomasal tissues and significant production losses to the sheep farming industry.
Hodgkinson, Suzanne Marie
core  

Therapeutic sequences in patients with grade 1−2 neuroendocrine tumors (NET): an observational multicenter study from the ELIOS group [PDF]

, 2019
Purpose: Many different treatments are suggested by guidelines to treat grade 1−2 (G1−G2) neuroendocrine tumors (NET). However, a precise therapeutic algorithm has not yet been established.
Badalamenti, G., Bianco, A., Colao, A., De Divitiis, C., Di Maio, S., Di Sarno, A., Dolce, P., Faggiano, A., Guarnotta, V., Leo, S., Mocerino, C., Modica, R., Ottaviano, M., Palmieri, G., Puliafito, I., Riccardi, F., Tafuto, S., Tozzi, L.   +17 more
core   +1 more source