Results 61 to 70 of about 115,117 (314)

Synthesis, Antiproliferative Effect and In Silico LogP Prediction of BIM-23052 Analogs Containing Tyr Instead of Phe

Pharmaceutics, 2023
(1) Background: Hydrophobicity (or lipophilicity) is a limiting factor in the ability of molecules to pass through cell membranes and to perform their function.
Dancho Danalev, Ivan Iliev, Stefan Dobrev, Silvia Angelova, Stoiko Petrin, Tatyana Dzimbova, Elena Ivanova, Dessislava Borisova, Emilia Naydenova   +8 more
doaj   +1 more source

Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP.

American Journal of Physiology. Endocrinology and Metabolism, 2015
The dysregulation of glucose-inhibited glucagon secretion from the pancreatic islet α-cell is a critical component of diabetes pathology and metabolic disease.
Amicia D Elliott, A. Ustione, D. Piston
semanticscholar   +1 more source

BRD4 Signaling Maintains the Differentiated State of β Cells

Advanced Science, EarlyView.
The comprehensive exploration revealed the critical role of BRD4 in β cells. BRD4 plays a fundamental role in maintaining β cell differentiation because both long‐term and acute BRD4 deficiency result in a reduction in insulin secretion and downregulation of differentiation markers.
Fuqiang Liu, Guang Liu, Jia Song, Yujing Sun, Mengmeng Yang, Hualin Liu, Hongkai Zhao, Jiamu Chen, Qincheng Qiao, Siyue Li, Chenglong Yu, Jingru Qu, Ying Zou, Tixiao Wang, Jidong Liu, Lei Zhao, Huihui Tian, Tao Huang, Manna Zhang, Li Chen, Ruxing Zhao, Yuanyuan Du, Xinguo Hou   +22 more
wiley   +1 more source

EXPRESSION OF INSULIN, GLUCAGON, SOMATOSTATIN, AND PANCREATIC POLYPEPTIDE IN THE PANCREAS OF THE EURASIAN MOORHEN (Gallinula chloropus)

Slovenian Veterinary Research, 2023
The pancreas is a complex gland that possesses both endocrine and exo-crine functions. The present study investigated the gross anatomy, histochemical fea-tures, and immunohistochemical expression of insulin, glucagon, somatostatin, and pancreatic ...
Ahmed Abdellatif
doaj   +1 more source

Enhancing Diagnostic Accuracy in Sinonasal Neuroendocrine Tumors: The Case for DOTATATE PET Over FDG PET

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Neuroendocrine tumors (NET) are a heterogeneous group of neoplasms that arise from neuroendocrine cells and commonly originate in the GI tract, lungs, and pancreas, but can also present in the skull base and paranasal sinuses. While fluorodeoxyglucose positron emission tomography (FDG PET) scans are routinely used in the evaluation of ...
Michael Sabbaj, Anandraj Kanwar, Jessica W. Grayson, Nyall R. London, Shirley Y. Su, Carl H. Snyderman, Brian D. Thorp, Dennis Tang, David Gudis, Eric W. Wang, Edward C. Kuan, Garett W. Choby, Mathew Geltzeiler   +12 more
wiley   +1 more source

Loss of Glutamate Decarboxylase 67 in Somatostatin-Expressing Neurons Leads to Anxiety-Like Behavior and Alteration in the Akt/GSK3β Signaling Pathway

Frontiers in Behavioral Neuroscience, 2019
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder worldwide. Several lines of evidence suggest that the dysfunction of somatostatin (SOM) neurons is associated with the pathophysiology of MDD.
Shigeo Miyata, Ryota Kumagaya, Toshikazu Kakizaki, Kazuyuki Fujihara, Kaori Wakamatsu, Yuchio Yanagawa   +5 more
doaj   +1 more source

Strategies for optimization of hypoglycemia rat models

Animal Models and Experimental Medicine, EarlyView.
This review focuses on rat models for studying the short‐term and long‐term effects of mild and severe hypoglycemia. We explored the physiological mechanisms to understand the consequences of hypoglycemia in rat experimental models. This study sheds light on uncovering the therapeutic potential for hypoglycemic patients and its efficacy in mitigating ...
Lee Yeong Zher, Eason Kong Qi Zheng, Rayneshia Elaura Raymond, Ye Zhen Jie, Christina Gertrude Yap   +4 more
wiley   +1 more source

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

Proceedings of the National Academy of Sciences of the United States of America, 1986
We have examined the regulation of somatostatin gene expression by cAMP in PC12 rat pheochromocytoma cells transfected with the rat somatostatin gene. Forskolin at 10 microM caused a 4-fold increase in somatostatin mRNA levels within 4 hr of treatment in
M. Montminy, K. Sevarino, John A. Wagner, G. Mandel, R. Goodman   +4 more
semanticscholar   +1 more source

Cell Type-Specific Expression of Corticotropin-Releasing Hormone-Binding Protein in GABAergic Interneurons in the Prefrontal Cortex

Frontiers in Neuroanatomy, 2017
Corticotropin-releasing hormone-binding protein (CRH-BP) is a secreted glycoprotein that binds CRH with very high affinity to modulate CRH receptor activity.
Kyle D. Ketchesin, Kyle D. Ketchesin, Nicholas S. Huang, Audrey F. Seasholtz, Audrey F. Seasholtz, Audrey F. Seasholtz   +5 more
doaj   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source