Results 61 to 70 of about 68,999 (229)

Clinical characteristics and outcome in 15 dogs treated with transsphenoidal hypophysectomy for nonfunctional sellar masses

Veterinary Surgery, Volume 52, Issue 1, Page 69-80, January 2023., 2023
Abstract Objective To characterize the clinical features, neurological examination findings, diagnostic imaging results, histopathological findings, and outcome following transsphenoidal hypophysectomy (TSH) in dogs with nonfunctional sellar masses (NFSM). Study design Multi‐institutional retrospective study.
Brittany R. Hyde, Linda G. Martin, Annie V. Chen, Sarah C. Guess, Sheila Carrera‐Justiz, David Bruyette, Tina J. Owen   +6 more
wiley   +1 more source

Loss of Glutamate Decarboxylase 67 in Somatostatin-Expressing Neurons Leads to Anxiety-Like Behavior and Alteration in the Akt/GSK3β Signaling Pathway

Frontiers in Behavioral Neuroscience, 2019
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder worldwide. Several lines of evidence suggest that the dysfunction of somatostatin (SOM) neurons is associated with the pathophysiology of MDD.
Shigeo Miyata, Ryota Kumagaya, Toshikazu Kakizaki, Kazuyuki Fujihara, Kaori Wakamatsu, Yuchio Yanagawa   +5 more
doaj   +1 more source

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Cell Type-Specific Expression of Corticotropin-Releasing Hormone-Binding Protein in GABAergic Interneurons in the Prefrontal Cortex

Frontiers in Neuroanatomy, 2017
Corticotropin-releasing hormone-binding protein (CRH-BP) is a secreted glycoprotein that binds CRH with very high affinity to modulate CRH receptor activity.
Kyle D. Ketchesin, Kyle D. Ketchesin, Nicholas S. Huang, Audrey F. Seasholtz, Audrey F. Seasholtz, Audrey F. Seasholtz   +5 more
doaj   +1 more source

Preoperative Glycosylated Hemoglobin A1C Impacts Long‐Term Outcomes Following Curative‐Intent Resection of Nonfunctional Gastroenteropancreatic Neuroendocrine Tumors

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background To investigate the impact of preoperative glycosylated hemoglobin A1C (HbA1c) among patients following curative‐intent resection of nonfunctional gastroentropancreatic neuroendocrine tumors (GEP‐NETs). Methods Patients who underwent curative‐intent resection for GEP‐NETs from 2000 to 2020 were identified from the US Neuroendocrine ...
Mu‐Xing Li, Alexandra G. Lopez‐Aguiar, George Poultsides, Flavio Rocha, Sharon Weber, Ryan Fields, Kamran Idrees, Cliff Cho, Shishir K. Maithel, Xu‐Feng Zhang, Timothy M. Pawlik   +10 more
wiley   +1 more source

Mechanisms underlying the response of mouse cortical networks to optogenetic manipulation [PDF]

arXiv, 2019
GABAergic interneurons can be subdivided into three subclasses: parvalbumin positive (PV), somatostatin positive (SOM) and serotonin positive neurons. With principal cells (PCs) they form complex networks. We examine PCs and PV responses in mouse anterior lateral motor cortex (ALM) and barrel cortex (S1) upon PV photostimulation in vivo.
arxiv  

A Reassessment of the Clinical Utility of 68Ga‐DOTATATE PET/CT in Patients With Gastroenteropancreatic Neuroendocrine Tumors

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background Gastroenteropancreatic neuroendocrine tumors (GEP‐NETs) are a rare and biologically diverse group of tumors that are challenging to image. 68Ga‐DOTATATE PET/CT is the most sensitive imaging tool for these tumors, and while its use has increased over time, its clinical impact remains unclear, particularly for clinical scenarios ...
Orjola Prela, Brennen Caveney, Myla Strawderman, David Linehan, Eva Galka, Luke Schoeniger, Aram Hezel, Nabeel Badri, Darren R. Carpizo   +8 more
wiley   +1 more source

Utilizing Peptide Ligand GPCRs to Image and Treat Pancreatic Cancer

Biomedicines, 2018
It is estimated that early detection of pancreatic ductal adenocarcinoma (PDAC) could increase long-term patient survival by as much as 30% to 40% (Seufferlein, T. et al., Nat. Rev. Gastroenterol. Hepatol. 2016, 13, 74–75).
Gail L. Matters, John F. Harms
doaj   +1 more source

Liposome‐Based Interventions in Knee Osteoarthritis

Small, EarlyView.
Liposomes offer new opportunities for the management of knee osteoarthritis (OA). This review examines the last decade's advances, focusing on intra‐articularly (IA) administered liposomes and liposome‐based systems as pharmaceutical carriers and lubricants, while discussing their in vivo efficacy. Functionalized liposomes (with polymers, peptides etc.)
Evgenia Mitsou, Jacob Klein
wiley   +1 more source

Neto Auxiliary Subunits Regulate Interneuron Somatodendritic and Presynaptic Kainate Receptors to Control Network Inhibition

Cell Reports, 2017
Although Netos are considered auxiliary subunits critical for kainate receptor (KAR) function, direct evidence for their regulation of native KARs is limited.
Megan S. Wyeth, Kenneth A. Pelkey, Xiaoqing Yuan, Geoffrey Vargish, April D. Johnston, Steven Hunt, Calvin Fang, Daniel Abebe, Vivek Mahadevan, André Fisahn, Michael W. Salter, Roderick R. McInnes, Ramesh Chittajallu, Chris J. McBain   +13 more
doaj   +1 more source