Results 61 to 70 of about 179,431 (364)
Hyperactive Somatostatin Interneurons Contribute to Excitotoxicity in Neurodegenerative Disorders
Nature Neuroscience, 2016 Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are overlapping neurodegenerative disorders whose pathogenesis remains largely unknown.
Wen Zhang +7 more
semanticscholar +1 more source
ACSS2/AATF Drives Soluble FasL‐Mediated CD8+ T Cell Apoptosis in Pancreatic Neuroendocrine Tumors
Advanced Science, EarlyView.This study unveils that ACSS2‐driven acetate metabolism fuels histone pan‐acetylation in pancreatic neuroendocrine tumors (PNETs), remodeling the epigenetic landscape. The ACSS2/AATF axis transcriptionally activates soluble FasL (sFasL), which engages Fas receptors on infiltrating CD8+ T cells to trigger caspase‐8/3‐mediated apoptosis.
Qin Dang +14 more
wiley +1 more source
, 2014 A novel radio guided surgery (RGS) technique for cerebral tumors using $\beta^{-}$ radiation is being developed. Checking the availability of a radio-tracer that can deliver a $\beta^{-}$ emitter to the tumor is a fundamental step in the deployment of ...
BELLINI, Fabio +23 more
core +1 more source
Substance P-expressing excitatory interneurons in the mouse superficial dorsal horn provide a propriospinal input to the lateral spinal nucleus [PDF]
, 2018 The superficial dorsal horn (laminae I and II) of the spinal cord contains numerous excitatory and inhibitory interneurons, and recent studies have shown that each of these groups can be divided into several neurochemically distinct populations. Although
Bell, Andrew M. +4 more
core +1 more source
Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion
Nature Network Boston, 2015 The peptide hormone urocortin3 (Ucn3) is abundantly expressed by mature beta cells, yet its physiological role is unknown. Here we demonstrate that Ucn3 is stored and co-released with insulin and potentiates glucose-stimulated somatostatin secretion via ...
T. van der Meulen +9 more
semanticscholar +1 more source
Advanced Science, EarlyView.In islet β cells, LGR4 binds with Rspondin to activate the Wnt‐β‐catenin‐Ccnd1 axis, leading to a subsequent increase in cell proliferation. On the other hand, LGR4 also binds with RANKL, thus suppressing the phosphorylation of p44/p42 MAPK and p65 NF‐κB and subsequent cell apoptosis.
Chao Luo +8 more
wiley +1 more source
The role of serotonin inhibition within the treatment of carcinoid syndrome
Endocrine Oncology, 2023 Carcinoid syndrome is the most frequent hormonal complication associated with neuroendocrine neoplasms. It was first reported in 1954, and the classical symptoms are diarrhoea, flushing and abdominal pain.
Joel George +3 more
doaj +1 more source
Somatostatin and Somatostatin-Containing Neurons in Shaping Neuronal Activity and Plasticity
Front. Neural Circuits, 2016 Since its discovery over four decades ago, somatostatin (SOM) receives growing scientific and clinical interest. Being localized in the nervous system in a subset of interneurons somatostatin acts as a neurotransmitter or neuromodulator and its role in ...
M. Liguz-Lęcznar +2 more
semanticscholar +1 more source
Annals of Gastroenterological Surgery, EarlyView.In patients with NELM, those with < 8 liver metastases and G1/2 tumors are the favorable candidates for liver resection. The important point of this study is that the patients who do not meet the above criteria should be considered for multidisciplinary treatment because of their extremely shorter recurrence‐free period.
Daisuke Asano +9 more
wiley +1 more source
Brazilian Journal of Biology, 2021 The work aims were to describe the histological and histochemical structure of the gastroesophageal tube of Iguana iguana and verify the occurrence and distribution of immunoreactive serotonin (5-HT) and somatostatin (SS) cells.
A. O. Serra-Campos +5 more
doaj +1 more source